Treatment of skin and soft tissue infections with imipenem/cilastatin
Ninety-eight adult patients with skin and soft tissue infections caused by a variety of bacterial pathogens were treated with imipenem/cilastatin (71), cefazolin (21), or moxalactam (six) at three medical centers. Favorable clinical responses were observed in 87 of the 90 evaluable cases (97 percent...
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| Veröffentlicht in: | The American journal of medicine 1985-06, Vol.78 (6), p.110-112 |
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| container_title | The American journal of medicine |
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| creator | Fass, Robert J. Freimer, Earl H. McCloskey, Richard V. |
| description | Ninety-eight adult patients with skin and soft tissue infections caused by a variety of bacterial pathogens were treated with imipenem/cilastatin (71), cefazolin (21), or moxalactam (six) at three medical centers. Favorable clinical responses were observed in 87 of the 90 evaluable cases (97 percent). Most etiologic pathogens were eradicated during treatment including five of seven which demonstrated in vitro resistance to the therapeutic agent. Strains that persisted during treatment were not associated with therapeutic failure except in one cefazolin-treated patient who was infected with Bacteroides fragilis. All three drugs were well tolerated and no specific patterns of adverse reactions were observed. |
| doi_str_mv | 10.1016/0002-9343(85)90111-1 |
| format | Article |
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Favorable clinical responses were observed in 87 of the 90 evaluable cases (97 percent). Most etiologic pathogens were eradicated during treatment including five of seven which demonstrated in vitro resistance to the therapeutic agent. Strains that persisted during treatment were not associated with therapeutic failure except in one cefazolin-treated patient who was infected with Bacteroides fragilis. 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All three drugs were well tolerated and no specific patterns of adverse reactions were observed.</description><subject>Adult</subject><subject>Aged</subject><subject>Bacteria - isolation & purification</subject><subject>Bacterial Infections - drug therapy</subject><subject>Cellulitis - drug therapy</subject><subject>Cilastatin</subject><subject>Clinical Trials as Topic</subject><subject>Cyclopropanes - administration & dosage</subject><subject>Drug Combinations</subject><subject>Humans</subject><subject>Imipenem</subject><subject>Middle Aged</subject><subject>Skin Diseases, Infectious - drug therapy</subject><subject>Thienamycins - administration & dosage</subject><issn>0002-9343</issn><issn>1555-7162</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAQx4Mo67r6DRR6Ej3UTZpHm4sgy_qABS_rOaTJFKNtuiZZxW9v6y4ePQ3D_zHMD6Fzgm8IJmKOMS5ySRm9qvi1xISQnBygKeGc5yURxSGa_lmO0UmMb8OKJRcTNKGVxJwWU7RcB9CpA5-yvsniu_OZ9jaLfZOy5GLcQuZ8Aya53sfsy6XXzHVuAx66uXGtjkkn50_RUaPbCGf7OUMv98v14jFfPT88Le5WuaG8TLkuLSkM47VguLBlCZxUrLa8aYzFxmBZaaZLXmugFdMgJRO1pEYILIEaa-gMXe56N6H_2EJMqnPRQNtqD_02qlIQRktJBiPbGU3oYwzQqE1wnQ7fimA10lMjGjWiURVXv_TUGLvY92_rDuxfaI9r0G93OgxPfjoIKhoH3oB1YWCkbO_-P_ADdvp-zg</recordid><startdate>19850607</startdate><enddate>19850607</enddate><creator>Fass, Robert J.</creator><creator>Freimer, Earl H.</creator><creator>McCloskey, Richard V.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19850607</creationdate><title>Treatment of skin and soft tissue infections with imipenem/cilastatin</title><author>Fass, Robert J. ; Freimer, Earl H. ; McCloskey, Richard V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-a7d12c45b6402d77e5184bd5ffcd0cc098a4a75bae384ae9946b93c6609e3cdc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Bacteria - isolation & purification</topic><topic>Bacterial Infections - drug therapy</topic><topic>Cellulitis - drug therapy</topic><topic>Cilastatin</topic><topic>Clinical Trials as Topic</topic><topic>Cyclopropanes - administration & dosage</topic><topic>Drug Combinations</topic><topic>Humans</topic><topic>Imipenem</topic><topic>Middle Aged</topic><topic>Skin Diseases, Infectious - drug therapy</topic><topic>Thienamycins - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fass, Robert J.</creatorcontrib><creatorcontrib>Freimer, Earl H.</creatorcontrib><creatorcontrib>McCloskey, Richard V.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fass, Robert J.</au><au>Freimer, Earl H.</au><au>McCloskey, Richard V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment of skin and soft tissue infections with imipenem/cilastatin</atitle><jtitle>The American journal of medicine</jtitle><addtitle>Am J Med</addtitle><date>1985-06-07</date><risdate>1985</risdate><volume>78</volume><issue>6</issue><spage>110</spage><epage>112</epage><pages>110-112</pages><issn>0002-9343</issn><eissn>1555-7162</eissn><abstract>Ninety-eight adult patients with skin and soft tissue infections caused by a variety of bacterial pathogens were treated with imipenem/cilastatin (71), cefazolin (21), or moxalactam (six) at three medical centers. 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| fulltext | fulltext |
| identifier | ISSN: 0002-9343 |
| ispartof | The American journal of medicine, 1985-06, Vol.78 (6), p.110-112 |
| issn | 0002-9343 1555-7162 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Aged Bacteria - isolation & purification Bacterial Infections - drug therapy Cellulitis - drug therapy Cilastatin Clinical Trials as Topic Cyclopropanes - administration & dosage Drug Combinations Humans Imipenem Middle Aged Skin Diseases, Infectious - drug therapy Thienamycins - administration & dosage |
| title | Treatment of skin and soft tissue infections with imipenem/cilastatin |
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