Inducible aldehyde dehydrogenases from rat liver cytosol

Two rat hepatic cytoplasmic isozymes of aldehyde dehydrogenase, φ, induced by phenobarbital treatment, and τ, induced by TCDD treatment, have been purified from rat hepatic cytosol by ammonium sulfate fractionation, followed by ion-exchange and affinity chromatography. The specific activities of the...

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Veröffentlicht in:	Toxicology and applied pharmacology 1985-06, Vol.79 (2), p.193-203
Hauptverfasser:	Simpson, V.J., Baker, R., Deitrich, R.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde Dehydrogenase - biosynthesis Aldehyde Dehydrogenase - isolation & purification Animals Biological and medical sciences Cytosol - drug effects Cytosol - enzymology Dioxins - pharmacology Electrophoresis, Polyacrylamide Gel Enzyme Induction General aspects. Methods Hydrogen-Ion Concentration Immunoelectrophoresis Isoelectric Point Isoenzymes - biosynthesis Isoenzymes - isolation & purification Liver - drug effects Liver - enzymology Male Medical sciences Molecular Weight Phenobarbital - pharmacology Polychlorinated Dibenzodioxins - pharmacology Rats Substrate Specificity Toxicology
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