Effects of chronic caffeine ingestion on growth and myocardial function (42114)
Abstract Experiments were conducted to determine whether chronic caffeine consumption during early growth and development affected cardiac performance and development of adipose tissue. Dams were fed a nutritionally complete diet with or without the addition of 10 mg/kg caffeine during lactation. Af...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1985-07, Vol.179 (3), p.388-395 |
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| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 179 |
| creator | Temples, T.E Geoffray, D.J Nakamoto, T Hartman, A.D Miller, H.I |
| description | Abstract
Experiments were conducted to determine whether chronic caffeine consumption during early growth and development affected cardiac performance and development of adipose tissue. Dams were fed a nutritionally complete diet with or without the addition of 10 mg/kg caffeine during lactation. After weaning, the pups were maintained on this diet until they were sacrificed at 88 days of age. Body weight at the time of sacrifice was comparable for both groups. The hearts from caffeine-fed animals were significantly (P |
| doi_str_mv | 10.3181/00379727-179-42114 |
| format | Article |
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Experiments were conducted to determine whether chronic caffeine consumption during early growth and development affected cardiac performance and development of adipose tissue. Dams were fed a nutritionally complete diet with or without the addition of 10 mg/kg caffeine during lactation. After weaning, the pups were maintained on this diet until they were sacrificed at 88 days of age. Body weight at the time of sacrifice was comparable for both groups. The hearts from caffeine-fed animals were significantly (P <0.05) larger based on both dry and wet weights although the dry weight/wet weight ratios were similar. Ventricular function curves were generated on each heart using an isolated working heart preparation. The isolated hearts of caffeine-fed rats exhibited a significant reduction in cardiac output, stroke volume, mean aortic pressure, and estimated myocardial work when compared to controls. The rats fed caffeine had greater plasma triglyceride levels with no significant differences in adipocyte size or number in the epididymal and perirenal depots. It is concluded that chronic caffeine intake from birth may alter cardiac function of the offspring.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1525-1373</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-179-42114</identifier><identifier>PMID: 4001133</identifier><identifier>CODEN: PSEBAA</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adipose Tissue - drug effects ; Animals ; Animals, Newborn ; Biological and medical sciences ; Blood Pressure - drug effects ; CAFEINA ; CAFEINE ; CAFFEINE ; Caffeine - pharmacology ; CRECIMIENTO ; CROISSANCE ; FOOD INTAKE ; Food toxicology ; GROWTH ; Growth - drug effects ; Heart - drug effects ; Heart Rate - drug effects ; INGESTION ; INGESTION DE ALIMENTOS ; Medical sciences ; MYOCARDIUM ; Oxygen Consumption - drug effects ; PRISE ALIMENTAIRE ; Rats ; Rats, Inbred Strains ; Respiration - drug effects ; Toxicology</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1985-07, Vol.179 (3), p.388-395</ispartof><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-325a75d212da4f6bb0efcba05a07c88ea5158d79e3f8cc7014b750b6f638a18c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8062452$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4001133$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Temples, T.E</creatorcontrib><creatorcontrib>Geoffray, D.J</creatorcontrib><creatorcontrib>Nakamoto, T</creatorcontrib><creatorcontrib>Hartman, A.D</creatorcontrib><creatorcontrib>Miller, H.I</creatorcontrib><title>Effects of chronic caffeine ingestion on growth and myocardial function (42114)</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Abstract
Experiments were conducted to determine whether chronic caffeine consumption during early growth and development affected cardiac performance and development of adipose tissue. Dams were fed a nutritionally complete diet with or without the addition of 10 mg/kg caffeine during lactation. After weaning, the pups were maintained on this diet until they were sacrificed at 88 days of age. Body weight at the time of sacrifice was comparable for both groups. The hearts from caffeine-fed animals were significantly (P <0.05) larger based on both dry and wet weights although the dry weight/wet weight ratios were similar. Ventricular function curves were generated on each heart using an isolated working heart preparation. The isolated hearts of caffeine-fed rats exhibited a significant reduction in cardiac output, stroke volume, mean aortic pressure, and estimated myocardial work when compared to controls. The rats fed caffeine had greater plasma triglyceride levels with no significant differences in adipocyte size or number in the epididymal and perirenal depots. It is concluded that chronic caffeine intake from birth may alter cardiac function of the offspring.</description><subject>Adipose Tissue - drug effects</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>CAFEINA</subject><subject>CAFEINE</subject><subject>CAFFEINE</subject><subject>Caffeine - pharmacology</subject><subject>CRECIMIENTO</subject><subject>CROISSANCE</subject><subject>FOOD INTAKE</subject><subject>Food toxicology</subject><subject>GROWTH</subject><subject>Growth - drug effects</subject><subject>Heart - drug effects</subject><subject>Heart Rate - drug effects</subject><subject>INGESTION</subject><subject>INGESTION DE ALIMENTOS</subject><subject>Medical sciences</subject><subject>MYOCARDIUM</subject><subject>Oxygen Consumption - drug effects</subject><subject>PRISE ALIMENTAIRE</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Respiration - drug effects</subject><subject>Toxicology</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1525-1373</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LJDEQhsOyoqO7f0AQ-rAseui1Kul0MsdF_ALBg-s5VKeTsaUn0WSaxX-_mY_1qBAIpJ63qvIwdozwS6DGcwCh5oqrGtW8bjhi84XNUHJZo1DiK5utgXpNHLDDnJ8BoAUO-2y_AUAUYsbuL713dpWr6Cv7lGIYbGWpvA3BVUNYuLwaYqjKWaT4d_VUUeir5Vu0lPqBxspPwW6I0838s29sz9OY3ffdfcQery7_XNzUd_fXtxe_72rboFrVgktSsufIe2p823XgvO0IJIGyWjuSKHWv5k54ba0CbDoloWt9KzShtuKI_dz2fUnxdSpbmuWQrRtHCi5O2ai2KFAIn4LYCJgLlAXkW9CmmHNy3rykYUnpzSCYtW7zX7cpus3muyV0sus-dUvXv0d2fkv9x65O2dLoEwU75HdMQ8sbyQt2vsUyLZx5jlMKRd7Hg4-3CU_R0CKVpo8PuuVcKxT_ADMVmz0</recordid><startdate>198507</startdate><enddate>198507</enddate><creator>Temples, T.E</creator><creator>Geoffray, D.J</creator><creator>Nakamoto, T</creator><creator>Hartman, A.D</creator><creator>Miller, H.I</creator><general>SAGE Publications</general><general>Blackwell Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>198507</creationdate><title>Effects of chronic caffeine ingestion on growth and myocardial function (42114)</title><author>Temples, T.E ; Geoffray, D.J ; Nakamoto, T ; Hartman, A.D ; Miller, H.I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-325a75d212da4f6bb0efcba05a07c88ea5158d79e3f8cc7014b750b6f638a18c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adipose Tissue - drug effects</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>CAFEINA</topic><topic>CAFEINE</topic><topic>CAFFEINE</topic><topic>Caffeine - pharmacology</topic><topic>CRECIMIENTO</topic><topic>CROISSANCE</topic><topic>FOOD INTAKE</topic><topic>Food toxicology</topic><topic>GROWTH</topic><topic>Growth - drug effects</topic><topic>Heart - drug effects</topic><topic>Heart Rate - drug effects</topic><topic>INGESTION</topic><topic>INGESTION DE ALIMENTOS</topic><topic>Medical sciences</topic><topic>MYOCARDIUM</topic><topic>Oxygen Consumption - drug effects</topic><topic>PRISE ALIMENTAIRE</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Respiration - drug effects</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Temples, T.E</creatorcontrib><creatorcontrib>Geoffray, D.J</creatorcontrib><creatorcontrib>Nakamoto, T</creatorcontrib><creatorcontrib>Hartman, A.D</creatorcontrib><creatorcontrib>Miller, H.I</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Temples, T.E</au><au>Geoffray, D.J</au><au>Nakamoto, T</au><au>Hartman, A.D</au><au>Miller, H.I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of chronic caffeine ingestion on growth and myocardial function (42114)</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1985-07</date><risdate>1985</risdate><volume>179</volume><issue>3</issue><spage>388</spage><epage>395</epage><pages>388-395</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1525-1373</eissn><eissn>1535-3699</eissn><coden>PSEBAA</coden><abstract>Abstract
Experiments were conducted to determine whether chronic caffeine consumption during early growth and development affected cardiac performance and development of adipose tissue. Dams were fed a nutritionally complete diet with or without the addition of 10 mg/kg caffeine during lactation. After weaning, the pups were maintained on this diet until they were sacrificed at 88 days of age. Body weight at the time of sacrifice was comparable for both groups. The hearts from caffeine-fed animals were significantly (P <0.05) larger based on both dry and wet weights although the dry weight/wet weight ratios were similar. Ventricular function curves were generated on each heart using an isolated working heart preparation. The isolated hearts of caffeine-fed rats exhibited a significant reduction in cardiac output, stroke volume, mean aortic pressure, and estimated myocardial work when compared to controls. The rats fed caffeine had greater plasma triglyceride levels with no significant differences in adipocyte size or number in the epididymal and perirenal depots. It is concluded that chronic caffeine intake from birth may alter cardiac function of the offspring.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>4001133</pmid><doi>10.3181/00379727-179-42114</doi><tpages>8</tpages></addata></record> |
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| subjects | Adipose Tissue - drug effects Animals Animals, Newborn Biological and medical sciences Blood Pressure - drug effects CAFEINA CAFEINE CAFFEINE Caffeine - pharmacology CRECIMIENTO CROISSANCE FOOD INTAKE Food toxicology GROWTH Growth - drug effects Heart - drug effects Heart Rate - drug effects INGESTION INGESTION DE ALIMENTOS Medical sciences MYOCARDIUM Oxygen Consumption - drug effects PRISE ALIMENTAIRE Rats Rats, Inbred Strains Respiration - drug effects Toxicology |
| title | Effects of chronic caffeine ingestion on growth and myocardial function (42114) |
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