Free flap survival improved by prostacyclin analogues
Free flap transplantations and replantations of extremities are threatened by venous occlusion in the postoperative course. In rats, free autogenous groin flaps were transplanted to the neck using microsurgical techniques. On the first postoperative day, the draining vein of the flap was temporarily...
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| Veröffentlicht in: | Microsurgery 1993, Vol.14 (7), p.464-467 |
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| creator | Frick, Andreas Baumeister, Rudiger G. H. Wohllaib, Ulrich |
| description | Free flap transplantations and replantations of extremities are threatened by venous occlusion in the postoperative course. In rats, free autogenous groin flaps were transplanted to the neck using microsurgical techniques. On the first postoperative day, the draining vein of the flap was temporarily clamped. In the control group there was always a total loss of the flaps by haemorrhagic necrosis. The intraarterial flap perfusion by lloprost during the clamping was able to diminish the ischaemic effects; 80% of the flaps survived. The systemic application of lloprost by intravenous infusion reduced the ischaemic effects in a similar way. Serious complications such as intraabdominal bleeding or bleeding in the donor area were seen after intravenous administration. Cicaprost had a similar protective effect on flap ischaemia after intravenous infusion. Flap survival was comparable to lloprost. Severe complications seemed to be less. Prostacyclin analogues were able to diminish damage of secondary ischaemia caused by venous occlusion. © 1993 Wiley‐Liss Inc. |
| doi_str_mv | 10.1002/micr.1920140710 |
| format | Article |
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H. ; Wohllaib, Ulrich</creator><creatorcontrib>Frick, Andreas ; Baumeister, Rudiger G. H. ; Wohllaib, Ulrich</creatorcontrib><description>Free flap transplantations and replantations of extremities are threatened by venous occlusion in the postoperative course. In rats, free autogenous groin flaps were transplanted to the neck using microsurgical techniques. On the first postoperative day, the draining vein of the flap was temporarily clamped. In the control group there was always a total loss of the flaps by haemorrhagic necrosis. The intraarterial flap perfusion by lloprost during the clamping was able to diminish the ischaemic effects; 80% of the flaps survived. The systemic application of lloprost by intravenous infusion reduced the ischaemic effects in a similar way. Serious complications such as intraabdominal bleeding or bleeding in the donor area were seen after intravenous administration. Cicaprost had a similar protective effect on flap ischaemia after intravenous infusion. Flap survival was comparable to lloprost. Severe complications seemed to be less. Prostacyclin analogues were able to diminish damage of secondary ischaemia caused by venous occlusion. © 1993 Wiley‐Liss Inc.</description><identifier>ISSN: 0738-1085</identifier><identifier>EISSN: 1098-2752</identifier><identifier>DOI: 10.1002/micr.1920140710</identifier><identifier>PMID: 7505376</identifier><identifier>CODEN: MSRGDQ</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Biological and medical sciences ; Cardiovascular system ; Epoprostenol - analogs & derivatives ; Epoprostenol - pharmacology ; Iloprost - pharmacology ; Ischemia - prevention & control ; Medical sciences ; Microsurgery ; Pharmacology. Drug treatments ; Rats ; Surgical Flaps ; Tissue Survival - drug effects ; Transplantation, Autologous ; Vasodilator agents. Cerebral vasodilators</subject><ispartof>Microsurgery, 1993, Vol.14 (7), p.464-467</ispartof><rights>Copyright © 1993 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4110-fc8bb1c73553d84b034eaa28bc37660e9236cffbb6e1830b1e0c5af343eec2d43</citedby><cites>FETCH-LOGICAL-c4110-fc8bb1c73553d84b034eaa28bc37660e9236cffbb6e1830b1e0c5af343eec2d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmicr.1920140710$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmicr.1920140710$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,4023,27922,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3776537$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7505376$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Frick, Andreas</creatorcontrib><creatorcontrib>Baumeister, Rudiger G. H.</creatorcontrib><creatorcontrib>Wohllaib, Ulrich</creatorcontrib><title>Free flap survival improved by prostacyclin analogues</title><title>Microsurgery</title><addtitle>Microsurgery</addtitle><description>Free flap transplantations and replantations of extremities are threatened by venous occlusion in the postoperative course. In rats, free autogenous groin flaps were transplanted to the neck using microsurgical techniques. On the first postoperative day, the draining vein of the flap was temporarily clamped. In the control group there was always a total loss of the flaps by haemorrhagic necrosis. The intraarterial flap perfusion by lloprost during the clamping was able to diminish the ischaemic effects; 80% of the flaps survived. The systemic application of lloprost by intravenous infusion reduced the ischaemic effects in a similar way. Serious complications such as intraabdominal bleeding or bleeding in the donor area were seen after intravenous administration. Cicaprost had a similar protective effect on flap ischaemia after intravenous infusion. Flap survival was comparable to lloprost. Severe complications seemed to be less. Prostacyclin analogues were able to diminish damage of secondary ischaemia caused by venous occlusion. © 1993 Wiley‐Liss Inc.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular system</subject><subject>Epoprostenol - analogs & derivatives</subject><subject>Epoprostenol - pharmacology</subject><subject>Iloprost - pharmacology</subject><subject>Ischemia - prevention & control</subject><subject>Medical sciences</subject><subject>Microsurgery</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Surgical Flaps</subject><subject>Tissue Survival - drug effects</subject><subject>Transplantation, Autologous</subject><subject>Vasodilator agents. Cerebral vasodilators</subject><issn>0738-1085</issn><issn>1098-2752</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFLAzEQhYMotVbPnoQ9iLfVyWaz2cWTFquCVRFF8RKSdFai2bYmbbX_3pSWiidPMzDfm_d4hOxTOKYA2UljjT-mVQY0B0Fhg7QpVGWaCZ5tkjYIVqYUSr5NdkJ4B4CqElWLtAQHzkTRJrznEZPaqXESpn5mZ8olthn70QwHiZ4ncQsTZebG2WGihsqN3qYYdslWrVzAvdXskKfexWP3Kr25u7zunt2kJqcU0tqUWlMjGOdsUOYaWI5KZaU20bsArDJWmLrWukBaMtAUwXBVs5whmmyQsw45Wv6NMT6j70Q2Nhh0Tg1xNA1SFJTlAmgET5agiXmDx1qOvW2Un0sKclGUXBQlf4uKioPV66lucLDmV83E--HqroJRrvZqaGxYY0yIInIRO11iX9bh_D9X2b_uPvwJkS7VNkzwe61W_kMWggkun28vZfVS3Z9f9bvylf0AiOuRXg</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>Frick, Andreas</creator><creator>Baumeister, Rudiger G. 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H. ; Wohllaib, Ulrich</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4110-fc8bb1c73553d84b034eaa28bc37660e9236cffbb6e1830b1e0c5af343eec2d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular system</topic><topic>Epoprostenol - analogs & derivatives</topic><topic>Epoprostenol - pharmacology</topic><topic>Iloprost - pharmacology</topic><topic>Ischemia - prevention & control</topic><topic>Medical sciences</topic><topic>Microsurgery</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Surgical Flaps</topic><topic>Tissue Survival - drug effects</topic><topic>Transplantation, Autologous</topic><topic>Vasodilator agents. Cerebral vasodilators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Frick, Andreas</creatorcontrib><creatorcontrib>Baumeister, Rudiger G. H.</creatorcontrib><creatorcontrib>Wohllaib, Ulrich</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Microsurgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Frick, Andreas</au><au>Baumeister, Rudiger G. H.</au><au>Wohllaib, Ulrich</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Free flap survival improved by prostacyclin analogues</atitle><jtitle>Microsurgery</jtitle><addtitle>Microsurgery</addtitle><date>1993</date><risdate>1993</risdate><volume>14</volume><issue>7</issue><spage>464</spage><epage>467</epage><pages>464-467</pages><issn>0738-1085</issn><eissn>1098-2752</eissn><coden>MSRGDQ</coden><abstract>Free flap transplantations and replantations of extremities are threatened by venous occlusion in the postoperative course. In rats, free autogenous groin flaps were transplanted to the neck using microsurgical techniques. On the first postoperative day, the draining vein of the flap was temporarily clamped. In the control group there was always a total loss of the flaps by haemorrhagic necrosis. The intraarterial flap perfusion by lloprost during the clamping was able to diminish the ischaemic effects; 80% of the flaps survived. The systemic application of lloprost by intravenous infusion reduced the ischaemic effects in a similar way. Serious complications such as intraabdominal bleeding or bleeding in the donor area were seen after intravenous administration. Cicaprost had a similar protective effect on flap ischaemia after intravenous infusion. Flap survival was comparable to lloprost. Severe complications seemed to be less. Prostacyclin analogues were able to diminish damage of secondary ischaemia caused by venous occlusion. © 1993 Wiley‐Liss Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>7505376</pmid><doi>10.1002/micr.1920140710</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0738-1085 |
| ispartof | Microsurgery, 1993, Vol.14 (7), p.464-467 |
| issn | 0738-1085 1098-2752 |
| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Animals Biological and medical sciences Cardiovascular system Epoprostenol - analogs & derivatives Epoprostenol - pharmacology Iloprost - pharmacology Ischemia - prevention & control Medical sciences Microsurgery Pharmacology. Drug treatments Rats Surgical Flaps Tissue Survival - drug effects Transplantation, Autologous Vasodilator agents. Cerebral vasodilators |
| title | Free flap survival improved by prostacyclin analogues |
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