Magnetic resonance imaging study of experimental acute spinal cord injury
Magnetic resonance imaging (MRI) has been used widely in the diagnosis of acute spinal cord injuries. The association between MRI findings and histologic changes, however, remains unclear. Using a rabbit spinal cord injury model, the authors compared the MRI and histologic abnormalities as they evol...
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| Veröffentlicht in: | Spine (Philadelphia, PA. 1976) PA. 1976), 1993-10, Vol.18 (14), p.2030-2034 |
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| creator | FUJII, H YONE, K SAKOU, T |
| description | Magnetic resonance imaging (MRI) has been used widely in the diagnosis of acute spinal cord injuries. The association between MRI findings and histologic changes, however, remains unclear. Using a rabbit spinal cord injury model, the authors compared the MRI and histologic abnormalities as they evolved over the first post-trauma month. Bleeding in the gray matter, visualized as a low-intensity area on T1-weighted views and high-intensity area on T2-weighted views, observed immediately after injury, disappeared within the first week. Edema, appearing 6 hours after the initial injury and seen as a high-intensity T2-weighted MRI image, became maximal 1 week later and gradually decreased thereafter. Also appearing 1 week later, were necrotic changes in the gray matter, corresponding to low signals on T1-weighted studies but high signals on T2-weighted studies. MRI therefore helped differentiate hemorrhage and necrosis, presumably irreversible lesions, from the more reversible findings related to edema. |
| doi_str_mv | 10.1097/00007632-199310001-00017 |
| format | Article |
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The association between MRI findings and histologic changes, however, remains unclear. Using a rabbit spinal cord injury model, the authors compared the MRI and histologic abnormalities as they evolved over the first post-trauma month. Bleeding in the gray matter, visualized as a low-intensity area on T1-weighted views and high-intensity area on T2-weighted views, observed immediately after injury, disappeared within the first week. Edema, appearing 6 hours after the initial injury and seen as a high-intensity T2-weighted MRI image, became maximal 1 week later and gradually decreased thereafter. Also appearing 1 week later, were necrotic changes in the gray matter, corresponding to low signals on T1-weighted studies but high signals on T2-weighted studies. MRI therefore helped differentiate hemorrhage and necrosis, presumably irreversible lesions, from the more reversible findings related to edema.</description><identifier>ISSN: 0362-2436</identifier><identifier>EISSN: 1528-1159</identifier><identifier>DOI: 10.1097/00007632-199310001-00017</identifier><identifier>PMID: 8272954</identifier><identifier>CODEN: SPINDD</identifier><language>eng</language><publisher>Philadelphia, PA: Lippincott</publisher><subject>Animals ; Biological and medical sciences ; Contrast Media ; Edema - pathology ; Gadolinium ; Gadolinium DTPA ; Hemorrhage - pathology ; Injuries of the nervous system and the skull. Diseases due to physical agents ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Necrosis - pathology ; Organometallic Compounds ; Paraplegia - etiology ; Paraplegia - pathology ; Pentetic Acid - analogs & derivatives ; Rabbits ; Spinal Cord - pathology ; Spinal Cord Compression - diagnosis ; Time Factors ; Traumas. 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The association between MRI findings and histologic changes, however, remains unclear. Using a rabbit spinal cord injury model, the authors compared the MRI and histologic abnormalities as they evolved over the first post-trauma month. Bleeding in the gray matter, visualized as a low-intensity area on T1-weighted views and high-intensity area on T2-weighted views, observed immediately after injury, disappeared within the first week. Edema, appearing 6 hours after the initial injury and seen as a high-intensity T2-weighted MRI image, became maximal 1 week later and gradually decreased thereafter. Also appearing 1 week later, were necrotic changes in the gray matter, corresponding to low signals on T1-weighted studies but high signals on T2-weighted studies. MRI therefore helped differentiate hemorrhage and necrosis, presumably irreversible lesions, from the more reversible findings related to edema.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Contrast Media</subject><subject>Edema - pathology</subject><subject>Gadolinium</subject><subject>Gadolinium DTPA</subject><subject>Hemorrhage - pathology</subject><subject>Injuries of the nervous system and the skull. Diseases due to physical agents</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Necrosis - pathology</subject><subject>Organometallic Compounds</subject><subject>Paraplegia - etiology</subject><subject>Paraplegia - pathology</subject><subject>Pentetic Acid - analogs & derivatives</subject><subject>Rabbits</subject><subject>Spinal Cord - pathology</subject><subject>Spinal Cord Compression - diagnosis</subject><subject>Time Factors</subject><subject>Traumas. Diseases due to physical agents</subject><issn>0362-2436</issn><issn>1528-1159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1PwzAMhiMEGmPwE5ByQNwKddI0yRFNfEwa4gLnKE3TKVOblqSV2L8nY2M-2LL8-rX8IIQhf4Bc8sc8BS8pyUBKCqmBbJ_4GZoDIyIDYPIczXNakowUtLxEVzFuk6SkIGdoJggnkhVztHrXG29HZ3CwsffaG4tdpzfOb3Acp3qH-wbbn8EG11k_6hZrM40Wx8H51Jg-1Nj57RR21-ii0W20N8e6QF8vz5_Lt2z98bpaPq0zQ4UcM7AFg6outBDSsgKAACuY5oRUpiGCcZrbUtaN5FwDE4Wo6oYAySvBCK0lpwt0f_AdQv892TiqzkVj21Z7209R8RIoYbRMQnEQmtDHGGyjhvSEDjsFudpTVP8U1Ymi-qOYVm-PN6aqs_Vp8Ygtze-Ocx2NbpuQuLl4klEuJE2Wv_vbeOU</recordid><startdate>19931015</startdate><enddate>19931015</enddate><creator>FUJII, H</creator><creator>YONE, K</creator><creator>SAKOU, T</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19931015</creationdate><title>Magnetic resonance imaging study of experimental acute spinal cord injury</title><author>FUJII, H ; YONE, K ; SAKOU, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-1e451bd4a889e541121545a722bcf285730e69df977a15848bdf2120b8523d973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Contrast Media</topic><topic>Edema - pathology</topic><topic>Gadolinium</topic><topic>Gadolinium DTPA</topic><topic>Hemorrhage - pathology</topic><topic>Injuries of the nervous system and the skull. Diseases due to physical agents</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Necrosis - pathology</topic><topic>Organometallic Compounds</topic><topic>Paraplegia - etiology</topic><topic>Paraplegia - pathology</topic><topic>Pentetic Acid - analogs & derivatives</topic><topic>Rabbits</topic><topic>Spinal Cord - pathology</topic><topic>Spinal Cord Compression - diagnosis</topic><topic>Time Factors</topic><topic>Traumas. Diseases due to physical agents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FUJII, H</creatorcontrib><creatorcontrib>YONE, K</creatorcontrib><creatorcontrib>SAKOU, T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Spine (Philadelphia, PA. 1976)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FUJII, H</au><au>YONE, K</au><au>SAKOU, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Magnetic resonance imaging study of experimental acute spinal cord injury</atitle><jtitle>Spine (Philadelphia, PA. 1976)</jtitle><addtitle>Spine (Phila Pa 1976)</addtitle><date>1993-10-15</date><risdate>1993</risdate><volume>18</volume><issue>14</issue><spage>2030</spage><epage>2034</epage><pages>2030-2034</pages><issn>0362-2436</issn><eissn>1528-1159</eissn><coden>SPINDD</coden><abstract>Magnetic resonance imaging (MRI) has been used widely in the diagnosis of acute spinal cord injuries. The association between MRI findings and histologic changes, however, remains unclear. Using a rabbit spinal cord injury model, the authors compared the MRI and histologic abnormalities as they evolved over the first post-trauma month. Bleeding in the gray matter, visualized as a low-intensity area on T1-weighted views and high-intensity area on T2-weighted views, observed immediately after injury, disappeared within the first week. Edema, appearing 6 hours after the initial injury and seen as a high-intensity T2-weighted MRI image, became maximal 1 week later and gradually decreased thereafter. Also appearing 1 week later, were necrotic changes in the gray matter, corresponding to low signals on T1-weighted studies but high signals on T2-weighted studies. MRI therefore helped differentiate hemorrhage and necrosis, presumably irreversible lesions, from the more reversible findings related to edema.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>8272954</pmid><doi>10.1097/00007632-199310001-00017</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Spine (Philadelphia, PA. 1976), 1993-10, Vol.18 (14), p.2030-2034 |
| issn | 0362-2436 1528-1159 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Biological and medical sciences Contrast Media Edema - pathology Gadolinium Gadolinium DTPA Hemorrhage - pathology Injuries of the nervous system and the skull. Diseases due to physical agents Magnetic Resonance Imaging Male Medical sciences Necrosis - pathology Organometallic Compounds Paraplegia - etiology Paraplegia - pathology Pentetic Acid - analogs & derivatives Rabbits Spinal Cord - pathology Spinal Cord Compression - diagnosis Time Factors Traumas. Diseases due to physical agents |
| title | Magnetic resonance imaging study of experimental acute spinal cord injury |
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