LEMAKALIM, A POTASSIUM CHANNEL AGONIST, REVERSES ELECTROPHYSIOLOGICAL IMPAIRMENTS INDUCED BY A LARGE DOSE OF BUPIVACAINE IN ANAESTHETIZED DOGS
We have examined the ability of lemakalim to correct bupivacaine-induced cardiac electrophysiological impairment in an experimental electrophysiological model in closed-chest dogs. Two groups (n = 6) of pentobarbitone-anaesthetized dogs were given atropine 0.2mg kg−1 i.v., and bupivacaine 4 mg kg−1...
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| Veröffentlicht in: | British journal of anaesthesia : BJA 1993-10, Vol.71 (4), p.534-539 |
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| creator | DE LA COUSSAYE, J.E. ELEDJAM, J.J. PERAY, P. BRUELLE, P. LEFRANT, J.Y. BASSOUL, B. DESCH, G. GAGNOL, J.P. SASSINE, A. |
| description | We have examined the ability of lemakalim to correct bupivacaine-induced cardiac electrophysiological impairment in an experimental electrophysiological model in closed-chest dogs. Two groups (n = 6) of pentobarbitone-anaesthetized dogs were given atropine 0.2mg kg−1 i.v., and bupivacaine 4 mg kg−1 i.v. over 10 s. Group 2 received also lemakalim 0.03 mg kg−1 i.v. Bupivacaine induced bradycardia, prolonged PR and His-ventricle (HV) intervals, QRS duration, QTc and JTc intervals, decreased left ventricular (LV) dP/dt max and increased LV end-diastolic pressure. Lemakalim reversed bupivacaine-induced PR, HV, ORS, QTc and JTc prolongation, and did not worsen bupivacaine-induced bradycardia and haemo dynamic depression. We conclude that lemakalim can antagonize the main deleterious electrophysiological effects induced by a large dose of bupivacaine in anaesthetized dogs. (Br. J. Anaesth. 1993; 71: 534–539) |
| doi_str_mv | 10.1093/bja/71.4.534 |
| format | Article |
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Two groups (n = 6) of pentobarbitone-anaesthetized dogs were given atropine 0.2mg kg−1 i.v., and bupivacaine 4 mg kg−1 i.v. over 10 s. Group 2 received also lemakalim 0.03 mg kg−1 i.v. Bupivacaine induced bradycardia, prolonged PR and His-ventricle (HV) intervals, QRS duration, QTc and JTc intervals, decreased left ventricular (LV) dP/dt max and increased LV end-diastolic pressure. Lemakalim reversed bupivacaine-induced PR, HV, ORS, QTc and JTc prolongation, and did not worsen bupivacaine-induced bradycardia and haemo dynamic depression. We conclude that lemakalim can antagonize the main deleterious electrophysiological effects induced by a large dose of bupivacaine in anaesthetized dogs. (Br. J. Anaesth. 1993; 71: 534–539)</description><identifier>ISSN: 0007-0912</identifier><identifier>EISSN: 1471-6771</identifier><identifier>DOI: 10.1093/bja/71.4.534</identifier><identifier>PMID: 8260303</identifier><identifier>CODEN: BJANAD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>anaesthetics ; anaesthetics, local: bupivacaine ; Anesthesia, General ; Animals ; Atropine - pharmacology ; Benzopyrans - pharmacology ; Biological and medical sciences ; Bupivacaine - antagonists & inhibitors ; Cromakalim ; Dogs ; Drug toxicity and drugs side effects treatment ; Electrocardiography - drug effects ; Female ; Heart - drug effects ; Heart Rate - drug effects ; heart: electrophysiology ; lemakalim ; local: bupivacaine ; Male ; Medical sciences ; Pharmacology. 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Two groups (n = 6) of pentobarbitone-anaesthetized dogs were given atropine 0.2mg kg−1 i.v., and bupivacaine 4 mg kg−1 i.v. over 10 s. Group 2 received also lemakalim 0.03 mg kg−1 i.v. Bupivacaine induced bradycardia, prolonged PR and His-ventricle (HV) intervals, QRS duration, QTc and JTc intervals, decreased left ventricular (LV) dP/dt max and increased LV end-diastolic pressure. Lemakalim reversed bupivacaine-induced PR, HV, ORS, QTc and JTc prolongation, and did not worsen bupivacaine-induced bradycardia and haemo dynamic depression. We conclude that lemakalim can antagonize the main deleterious electrophysiological effects induced by a large dose of bupivacaine in anaesthetized dogs. (Br. J. 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Drug treatments</subject><subject>pharmacology: potassium channel agonist</subject><subject>pharmacology: potassium channel agonist, lemakalim</subject><subject>Potassium Channels - drug effects</subject><subject>Pyrroles - pharmacology</subject><subject>Time Factors</subject><subject>toxicity: bupivacaine</subject><subject>Toxicity: cardiovascular system</subject><issn>0007-0912</issn><issn>1471-6771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0E1v0zAcBvAIgUYZ3Lgi-YA4NZ0dJ3F89FKvtchLSdKJ9WI5jitl68uIW7R9CT4zRq164uTD89Pztx7P-4zgBEGKb9pHdUPQJJxEOHzjjVBIkB8Tgt56Iwgh8SFFwXvvg7WPECIS0OjKu0qCGGKIR96fjOfsO8tEPgYMLMqG1bVY5iCds6LgGWCzshB1MwYVv-dVzWvAM542VbmYP9SizMqZSFkGRL5gosp50dRAFNNlyqfg9sE1ZqyacTAtaw7KO3C7XIh7ljJRcMcAKxivmzlvxMr5aTmrP3rv1mpjzafze-0t73iTzv3zIV-HcXjww66FJIBtgtukNTpBIaaqjdu2SyikWie67SKjsMZRiFWgI2qcDEyETZAYovC19-3U-zzsfx2NPchtb7XZbNTO7I9WkhhhRCl1cHyCethbO5i1fB76rRpeJYLy3_zSzS8JkqF08zv-5dx7bLemu-Dz3i7_es6V1WqzHtRO9_bCwiShOECO-SfW24N5ucRqeJIxwSSS858rGZAI_litKpk5H5-8cZv97s0gre7NTpuuH4w-yG7f__-_fwERjqOi</recordid><startdate>19931001</startdate><enddate>19931001</enddate><creator>DE LA COUSSAYE, J.E.</creator><creator>ELEDJAM, J.J.</creator><creator>PERAY, P.</creator><creator>BRUELLE, P.</creator><creator>LEFRANT, J.Y.</creator><creator>BASSOUL, B.</creator><creator>DESCH, G.</creator><creator>GAGNOL, J.P.</creator><creator>SASSINE, A.</creator><general>Elsevier Ltd</general><general>Oxford University Press</general><scope>6I.</scope><scope>AAFTH</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19931001</creationdate><title>LEMAKALIM, A POTASSIUM CHANNEL AGONIST, REVERSES ELECTROPHYSIOLOGICAL IMPAIRMENTS INDUCED BY A LARGE DOSE OF BUPIVACAINE IN ANAESTHETIZED DOGS</title><author>DE LA COUSSAYE, J.E. ; ELEDJAM, J.J. ; PERAY, P. ; BRUELLE, P. ; LEFRANT, J.Y. ; BASSOUL, B. ; DESCH, G. ; GAGNOL, J.P. ; SASSINE, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-4db0720b83b8bec81439ab6bbd8909cc8cbd5ea3c3543a2c59e3b82e53e28e7a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>anaesthetics</topic><topic>anaesthetics, local: bupivacaine</topic><topic>Anesthesia, General</topic><topic>Animals</topic><topic>Atropine - pharmacology</topic><topic>Benzopyrans - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Bupivacaine - antagonists & inhibitors</topic><topic>Cromakalim</topic><topic>Dogs</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Electrocardiography - drug effects</topic><topic>Female</topic><topic>Heart - drug effects</topic><topic>Heart Rate - drug effects</topic><topic>heart: electrophysiology</topic><topic>lemakalim</topic><topic>local: bupivacaine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>pharmacology: potassium channel agonist</topic><topic>pharmacology: potassium channel agonist, lemakalim</topic><topic>Potassium Channels - drug effects</topic><topic>Pyrroles - pharmacology</topic><topic>Time Factors</topic><topic>toxicity: bupivacaine</topic><topic>Toxicity: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DE LA COUSSAYE, J.E.</creatorcontrib><creatorcontrib>ELEDJAM, J.J.</creatorcontrib><creatorcontrib>PERAY, P.</creatorcontrib><creatorcontrib>BRUELLE, P.</creatorcontrib><creatorcontrib>LEFRANT, J.Y.</creatorcontrib><creatorcontrib>BASSOUL, B.</creatorcontrib><creatorcontrib>DESCH, G.</creatorcontrib><creatorcontrib>GAGNOL, J.P.</creatorcontrib><creatorcontrib>SASSINE, A.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of anaesthesia : BJA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DE LA COUSSAYE, J.E.</au><au>ELEDJAM, J.J.</au><au>PERAY, P.</au><au>BRUELLE, P.</au><au>LEFRANT, J.Y.</au><au>BASSOUL, B.</au><au>DESCH, G.</au><au>GAGNOL, J.P.</au><au>SASSINE, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>LEMAKALIM, A POTASSIUM CHANNEL AGONIST, REVERSES ELECTROPHYSIOLOGICAL IMPAIRMENTS INDUCED BY A LARGE DOSE OF BUPIVACAINE IN ANAESTHETIZED DOGS</atitle><jtitle>British journal of anaesthesia : BJA</jtitle><addtitle>Br J Anaesth</addtitle><date>1993-10-01</date><risdate>1993</risdate><volume>71</volume><issue>4</issue><spage>534</spage><epage>539</epage><pages>534-539</pages><issn>0007-0912</issn><eissn>1471-6771</eissn><coden>BJANAD</coden><abstract>We have examined the ability of lemakalim to correct bupivacaine-induced cardiac electrophysiological impairment in an experimental electrophysiological model in closed-chest dogs. Two groups (n = 6) of pentobarbitone-anaesthetized dogs were given atropine 0.2mg kg−1 i.v., and bupivacaine 4 mg kg−1 i.v. over 10 s. Group 2 received also lemakalim 0.03 mg kg−1 i.v. Bupivacaine induced bradycardia, prolonged PR and His-ventricle (HV) intervals, QRS duration, QTc and JTc intervals, decreased left ventricular (LV) dP/dt max and increased LV end-diastolic pressure. Lemakalim reversed bupivacaine-induced PR, HV, ORS, QTc and JTc prolongation, and did not worsen bupivacaine-induced bradycardia and haemo dynamic depression. We conclude that lemakalim can antagonize the main deleterious electrophysiological effects induced by a large dose of bupivacaine in anaesthetized dogs. (Br. J. Anaesth. 1993; 71: 534–539)</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>8260303</pmid><doi>10.1093/bja/71.4.534</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Archive; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | anaesthetics anaesthetics, local: bupivacaine Anesthesia, General Animals Atropine - pharmacology Benzopyrans - pharmacology Biological and medical sciences Bupivacaine - antagonists & inhibitors Cromakalim Dogs Drug toxicity and drugs side effects treatment Electrocardiography - drug effects Female Heart - drug effects Heart Rate - drug effects heart: electrophysiology lemakalim local: bupivacaine Male Medical sciences Pharmacology. Drug treatments pharmacology: potassium channel agonist pharmacology: potassium channel agonist, lemakalim Potassium Channels - drug effects Pyrroles - pharmacology Time Factors toxicity: bupivacaine Toxicity: cardiovascular system |
| title | LEMAKALIM, A POTASSIUM CHANNEL AGONIST, REVERSES ELECTROPHYSIOLOGICAL IMPAIRMENTS INDUCED BY A LARGE DOSE OF BUPIVACAINE IN ANAESTHETIZED DOGS |
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