Therapy with Antibody to Tumor Necrosis Factor in Sepsis

Recent data indicate that proinflammatory cytokines mediate pathophysiological events during clinical sepsis. The cytokine tumor necrosis factor (TNF) has been closely associated with adverse outcome from sepsis, both in animal models and in the clinical setting. Accordingly, monoclonal antibodies w...

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Veröffentlicht in:	Clinical infectious diseases 1993-11, Vol.17 (Supplement-2), p.S515-S519
1. Verfasser:	PENNINGTON, J. E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antibodies Antibodies - therapeutic use Antibodies, Monoclonal - therapeutic use Biological and medical sciences Disease Models, Animal Endotoxins Humans Infections Management of Sepsis Medical sciences Mice Monoclonal antibodies Mortality Papio Pharmacology. Drug treatments Sepsis Septic shock Shock, Septic - therapy Survival Analysis Tumor Necrosis Factor-alpha - analysis Tumor Necrosis Factor-alpha - immunology Tumor necrosis factors
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