Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins

BINDING of interferons IFN-α and IFN-γ to their cell surface receptors promptly induces tyrosine phosphorylation of latent cytoplasmic transcriptional activators 1–4 (or Stat proteins, for signal transducers and activators of transcription). Interferon-α activates both Stat91 ( M r 91,000; ref. 1) a...

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Veröffentlicht in:	Nature (London) 1993-12, Vol.366 (6455), p.580-583
Hauptverfasser:	Shuai, Ke, Ziemiecki, Andrew, Wilks, Andrew F., Harpur, Ailsa G., Sadowski, Henry B., Gilman, Michael Z., Darnell, James E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence B-Lymphocytes - drug effects B-Lymphocytes - metabolism Base Sequence Binding Sites Biological and medical sciences Cell Line Cell physiology Cellular biology Epidermal Growth Factor - pharmacology Fundamental and applied biological sciences. Psychology Glutathione Transferase - metabolism Humanities and Social Sciences Humans Interferon-alpha - pharmacology Interferon-gamma - pharmacology Janus Kinase 1 Janus Kinase 2 letter Molecular and cellular biology Molecular Sequence Data multidisciplinary Phosphorylation Phosphotyrosine Protein-Tyrosine Kinases - metabolism Proteins Proto-Oncogene Proteins Recombinant Fusion Proteins - metabolism Science Science (multidisciplinary) Signal transduction Trans-Activators - metabolism Tumor Cells, Cultured Tyrosine - analogs & derivatives Tyrosine - analysis Tyrosine - metabolism
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