Bradykinin and capsaicin stimulate cyclic GMP production in cultured rat dorsal root ganglion neurons via a nitrosyl intermediate
Dorsal root ganglion (DRG) neurons express receptors for bradykinin and capsaicin, both algesic substances. Administration of bradykinin or capsaicin to neurons cultured from embryonic rat DRG stimulated the production of cyclic GMP but in nonneuronal DRG cultures. Bradykinin‐evoked Cyclic GMP produ...
Gespeichert in:
| Veröffentlicht in: | Journal of neuroscience research 1993-10, Vol.36 (3), p.280-289 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 289 |
|---|---|
| container_issue | 3 |
| container_start_page | 280 |
| container_title | Journal of neuroscience research |
| container_volume | 36 |
| creator | Bauer, M. B. Simmons, M. L. Murphy, S. Gebhart, G. F. |
| description | Dorsal root ganglion (DRG) neurons express receptors for bradykinin and capsaicin, both algesic substances. Administration of bradykinin or capsaicin to neurons cultured from embryonic rat DRG stimulated the production of cyclic GMP but in nonneuronal DRG cultures. Bradykinin‐evoked Cyclic GMP production was mediated by B2 receptors and was unaltered by indomethacin. Both bradykinin‐ and capsaicin‐stimulated cyclim GMP production required Ca2+ and was inhibited by methylene blue. Furthermore, methylene blue attenuated basal cyclic GMP production in DRG neurons, suggesting tonic cyclic GMP production in these Cells. L‐NG‐monomethyl arginine inhibited both bradykinin‐and capsaicin‐stimulated cylic GMP production as well as basal cyclic GMP production. These findings suggest the involvement of a nitrosyl compound in bradykinin‐and capsaicinstimulated cyclic GMP production and in tonic cyclic GMP production in DRG Neurons. © 1993 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/jnr.490360306 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76128900</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>76128900</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4346-7ca13db84c2ac34c221193daac47365ee357226c386b138784a4c5b11b6daef3</originalsourceid><addsrcrecordid>eNqFkc1v1DAQxS0EKkvhyBHJB8QtxV-xkyOtYGG1LQhV4mhNHG_l1ussttOSI_85Xm204tRebNnzmzfz9BB6S8kZJYR9vA3xTLSES8KJfIYWlLSqErVQz9Fi_1sJQtlL9CqlW0JI29b8BJ2o0qCIWKC_5xH66c4FFzCEHhvYJXCmvFJ229FDtthMxjuDl5c_8C4O_WiyGwIuiBl9HqPtcYSM-yEm8DgOQ8Y3EG78Hgp2jENI-N4BBhxcjkOafOnNNm5t74r8a_RiAz7ZN_N9iq6_fL6--Fqtvy-_XXxaV0ZwIStlgPK-a4RhYHg5GaUt7wGMUFzW1vJaMSYNb2RHeaMaAcLUHaWd7MFu-Cn6cJAtFn6PNmW9dclY7yHYYUxaScqalpAnQSqlqqmsC1gdQFNMpWg3ehfdFuKkKdH7aHSJRh-jKfy7WXjsivcjPWdR6u_nOiQDfhMhGJeOGFct5Wwvow7Yg_N2enymXl39_H-BeWGXsv1z7IR4p6Xiqta_rpa6uTxfr9RKacb_AWJit-g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16675165</pqid></control><display><type>article</type><title>Bradykinin and capsaicin stimulate cyclic GMP production in cultured rat dorsal root ganglion neurons via a nitrosyl intermediate</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Bauer, M. B. ; Simmons, M. L. ; Murphy, S. ; Gebhart, G. F.</creator><creatorcontrib>Bauer, M. B. ; Simmons, M. L. ; Murphy, S. ; Gebhart, G. F.</creatorcontrib><description>Dorsal root ganglion (DRG) neurons express receptors for bradykinin and capsaicin, both algesic substances. Administration of bradykinin or capsaicin to neurons cultured from embryonic rat DRG stimulated the production of cyclic GMP but in nonneuronal DRG cultures. Bradykinin‐evoked Cyclic GMP production was mediated by B2 receptors and was unaltered by indomethacin. Both bradykinin‐ and capsaicin‐stimulated cyclim GMP production required Ca2+ and was inhibited by methylene blue. Furthermore, methylene blue attenuated basal cyclic GMP production in DRG neurons, suggesting tonic cyclic GMP production in these Cells. L‐NG‐monomethyl arginine inhibited both bradykinin‐and capsaicin‐stimulated cylic GMP production as well as basal cyclic GMP production. These findings suggest the involvement of a nitrosyl compound in bradykinin‐and capsaicinstimulated cyclic GMP production and in tonic cyclic GMP production in DRG Neurons. © 1993 Wiley‐Liss, Inc.</description><identifier>ISSN: 0360-4012</identifier><identifier>EISSN: 1097-4547</identifier><identifier>DOI: 10.1002/jnr.490360306</identifier><identifier>PMID: 7903704</identifier><identifier>CODEN: JNREDK</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Arginine - analogs & derivatives ; Arginine - pharmacology ; Biological and medical sciences ; Bradykinin - analogs & derivatives ; Bradykinin - pharmacology ; Bradykinin Receptor Antagonists ; Calcium - pharmacology ; Capsaicin - pharmacology ; Cells, Cultured ; Cyclic GMP - biosynthesis ; Fundamental and applied biological sciences. Psychology ; Ganglia, Spinal - drug effects ; Ganglia, Spinal - embryology ; Ganglia, Spinal - metabolism ; guanylate cyclase ; Guanylate Cyclase - antagonists & inhibitors ; Methylene Blue - pharmacology ; Neurons - drug effects ; Neurons - metabolism ; nitric oxide ; Nitric Oxide - metabolism ; nitric oxide synthase ; nociception ; omega-N-Methylarginine ; Rats ; Rats, Sprague-Dawley ; Receptors, Bradykinin - physiology ; sensory afferents ; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors ; Vertebrates: nervous system and sense organs</subject><ispartof>Journal of neuroscience research, 1993-10, Vol.36 (3), p.280-289</ispartof><rights>Copyright © 1993 Wiley‐Liss, Inc.</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4346-7ca13db84c2ac34c221193daac47365ee357226c386b138784a4c5b11b6daef3</citedby><cites>FETCH-LOGICAL-c4346-7ca13db84c2ac34c221193daac47365ee357226c386b138784a4c5b11b6daef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjnr.490360306$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjnr.490360306$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3791326$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7903704$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bauer, M. B.</creatorcontrib><creatorcontrib>Simmons, M. L.</creatorcontrib><creatorcontrib>Murphy, S.</creatorcontrib><creatorcontrib>Gebhart, G. F.</creatorcontrib><title>Bradykinin and capsaicin stimulate cyclic GMP production in cultured rat dorsal root ganglion neurons via a nitrosyl intermediate</title><title>Journal of neuroscience research</title><addtitle>J. Neurosci. Res</addtitle><description>Dorsal root ganglion (DRG) neurons express receptors for bradykinin and capsaicin, both algesic substances. Administration of bradykinin or capsaicin to neurons cultured from embryonic rat DRG stimulated the production of cyclic GMP but in nonneuronal DRG cultures. Bradykinin‐evoked Cyclic GMP production was mediated by B2 receptors and was unaltered by indomethacin. Both bradykinin‐ and capsaicin‐stimulated cyclim GMP production required Ca2+ and was inhibited by methylene blue. Furthermore, methylene blue attenuated basal cyclic GMP production in DRG neurons, suggesting tonic cyclic GMP production in these Cells. L‐NG‐monomethyl arginine inhibited both bradykinin‐and capsaicin‐stimulated cylic GMP production as well as basal cyclic GMP production. These findings suggest the involvement of a nitrosyl compound in bradykinin‐and capsaicinstimulated cyclic GMP production and in tonic cyclic GMP production in DRG Neurons. © 1993 Wiley‐Liss, Inc.</description><subject>Animals</subject><subject>Arginine - analogs & derivatives</subject><subject>Arginine - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Bradykinin - analogs & derivatives</subject><subject>Bradykinin - pharmacology</subject><subject>Bradykinin Receptor Antagonists</subject><subject>Calcium - pharmacology</subject><subject>Capsaicin - pharmacology</subject><subject>Cells, Cultured</subject><subject>Cyclic GMP - biosynthesis</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ganglia, Spinal - drug effects</subject><subject>Ganglia, Spinal - embryology</subject><subject>Ganglia, Spinal - metabolism</subject><subject>guanylate cyclase</subject><subject>Guanylate Cyclase - antagonists & inhibitors</subject><subject>Methylene Blue - pharmacology</subject><subject>Neurons - drug effects</subject><subject>Neurons - metabolism</subject><subject>nitric oxide</subject><subject>Nitric Oxide - metabolism</subject><subject>nitric oxide synthase</subject><subject>nociception</subject><subject>omega-N-Methylarginine</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Bradykinin - physiology</subject><subject>sensory afferents</subject><subject>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0360-4012</issn><issn>1097-4547</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1v1DAQxS0EKkvhyBHJB8QtxV-xkyOtYGG1LQhV4mhNHG_l1ussttOSI_85Xm204tRebNnzmzfz9BB6S8kZJYR9vA3xTLSES8KJfIYWlLSqErVQz9Fi_1sJQtlL9CqlW0JI29b8BJ2o0qCIWKC_5xH66c4FFzCEHhvYJXCmvFJ229FDtthMxjuDl5c_8C4O_WiyGwIuiBl9HqPtcYSM-yEm8DgOQ8Y3EG78Hgp2jENI-N4BBhxcjkOafOnNNm5t74r8a_RiAz7ZN_N9iq6_fL6--Fqtvy-_XXxaV0ZwIStlgPK-a4RhYHg5GaUt7wGMUFzW1vJaMSYNb2RHeaMaAcLUHaWd7MFu-Cn6cJAtFn6PNmW9dclY7yHYYUxaScqalpAnQSqlqqmsC1gdQFNMpWg3ehfdFuKkKdH7aHSJRh-jKfy7WXjsivcjPWdR6u_nOiQDfhMhGJeOGFct5Wwvow7Yg_N2enymXl39_H-BeWGXsv1z7IR4p6Xiqta_rpa6uTxfr9RKacb_AWJit-g</recordid><startdate>19931015</startdate><enddate>19931015</enddate><creator>Bauer, M. B.</creator><creator>Simmons, M. L.</creator><creator>Murphy, S.</creator><creator>Gebhart, G. F.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19931015</creationdate><title>Bradykinin and capsaicin stimulate cyclic GMP production in cultured rat dorsal root ganglion neurons via a nitrosyl intermediate</title><author>Bauer, M. B. ; Simmons, M. L. ; Murphy, S. ; Gebhart, G. F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4346-7ca13db84c2ac34c221193daac47365ee357226c386b138784a4c5b11b6daef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Arginine - analogs & derivatives</topic><topic>Arginine - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Bradykinin - analogs & derivatives</topic><topic>Bradykinin - pharmacology</topic><topic>Bradykinin Receptor Antagonists</topic><topic>Calcium - pharmacology</topic><topic>Capsaicin - pharmacology</topic><topic>Cells, Cultured</topic><topic>Cyclic GMP - biosynthesis</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ganglia, Spinal - drug effects</topic><topic>Ganglia, Spinal - embryology</topic><topic>Ganglia, Spinal - metabolism</topic><topic>guanylate cyclase</topic><topic>Guanylate Cyclase - antagonists & inhibitors</topic><topic>Methylene Blue - pharmacology</topic><topic>Neurons - drug effects</topic><topic>Neurons - metabolism</topic><topic>nitric oxide</topic><topic>Nitric Oxide - metabolism</topic><topic>nitric oxide synthase</topic><topic>nociception</topic><topic>omega-N-Methylarginine</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Bradykinin - physiology</topic><topic>sensory afferents</topic><topic>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bauer, M. B.</creatorcontrib><creatorcontrib>Simmons, M. L.</creatorcontrib><creatorcontrib>Murphy, S.</creatorcontrib><creatorcontrib>Gebhart, G. F.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroscience research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bauer, M. B.</au><au>Simmons, M. L.</au><au>Murphy, S.</au><au>Gebhart, G. F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bradykinin and capsaicin stimulate cyclic GMP production in cultured rat dorsal root ganglion neurons via a nitrosyl intermediate</atitle><jtitle>Journal of neuroscience research</jtitle><addtitle>J. Neurosci. Res</addtitle><date>1993-10-15</date><risdate>1993</risdate><volume>36</volume><issue>3</issue><spage>280</spage><epage>289</epage><pages>280-289</pages><issn>0360-4012</issn><eissn>1097-4547</eissn><coden>JNREDK</coden><abstract>Dorsal root ganglion (DRG) neurons express receptors for bradykinin and capsaicin, both algesic substances. Administration of bradykinin or capsaicin to neurons cultured from embryonic rat DRG stimulated the production of cyclic GMP but in nonneuronal DRG cultures. Bradykinin‐evoked Cyclic GMP production was mediated by B2 receptors and was unaltered by indomethacin. Both bradykinin‐ and capsaicin‐stimulated cyclim GMP production required Ca2+ and was inhibited by methylene blue. Furthermore, methylene blue attenuated basal cyclic GMP production in DRG neurons, suggesting tonic cyclic GMP production in these Cells. L‐NG‐monomethyl arginine inhibited both bradykinin‐and capsaicin‐stimulated cylic GMP production as well as basal cyclic GMP production. These findings suggest the involvement of a nitrosyl compound in bradykinin‐and capsaicinstimulated cyclic GMP production and in tonic cyclic GMP production in DRG Neurons. © 1993 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>7903704</pmid><doi>10.1002/jnr.490360306</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0360-4012 |
| ispartof | Journal of neuroscience research, 1993-10, Vol.36 (3), p.280-289 |
| issn | 0360-4012 1097-4547 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76128900 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Arginine - analogs & derivatives Arginine - pharmacology Biological and medical sciences Bradykinin - analogs & derivatives Bradykinin - pharmacology Bradykinin Receptor Antagonists Calcium - pharmacology Capsaicin - pharmacology Cells, Cultured Cyclic GMP - biosynthesis Fundamental and applied biological sciences. Psychology Ganglia, Spinal - drug effects Ganglia, Spinal - embryology Ganglia, Spinal - metabolism guanylate cyclase Guanylate Cyclase - antagonists & inhibitors Methylene Blue - pharmacology Neurons - drug effects Neurons - metabolism nitric oxide Nitric Oxide - metabolism nitric oxide synthase nociception omega-N-Methylarginine Rats Rats, Sprague-Dawley Receptors, Bradykinin - physiology sensory afferents Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Vertebrates: nervous system and sense organs |
| title | Bradykinin and capsaicin stimulate cyclic GMP production in cultured rat dorsal root ganglion neurons via a nitrosyl intermediate |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T07%3A44%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Bradykinin%20and%20capsaicin%20stimulate%20cyclic%20GMP%20production%20in%20cultured%20rat%20dorsal%20root%20ganglion%20neurons%20via%20a%20nitrosyl%20intermediate&rft.jtitle=Journal%20of%20neuroscience%20research&rft.au=Bauer,%20M.%20B.&rft.date=1993-10-15&rft.volume=36&rft.issue=3&rft.spage=280&rft.epage=289&rft.pages=280-289&rft.issn=0360-4012&rft.eissn=1097-4547&rft.coden=JNREDK&rft_id=info:doi/10.1002/jnr.490360306&rft_dat=%3Cproquest_cross%3E76128900%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16675165&rft_id=info:pmid/7903704&rfr_iscdi=true |