The effect of pH on interaction of nitrobenzylthioinosine and hydroxynitrobenzylthioinosine with the nucleoside transporter of human erythrocyte membranes

Site-specific binding to human erythrocyte membranes of nitrobenzylthioinosine (NBMPR), un-ionized at physiological pH, was compared with that of hydroxynitrobenzylthioinosine (HNBMPR), pKa 6.4, at graded pH values. Binding of [3H]NBMPR was measured directly, and that of HNBMPR was assayed by compet...

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Veröffentlicht in:	Molecular pharmacology 1985-06, Vol.27 (6), p.662-665
Hauptverfasser:	Cass, C E, Gati, W P, Odegard, R, Paterson, A R
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Labels - pharmacology Binding, Competitive Blood Proteins - metabolism Carrier Proteins - metabolism Erythrocyte Membrane - drug effects Erythrocyte Membrane - metabolism Guanosine - analogs & derivatives Guanosine - pharmacology Humans Hydrogen-Ion Concentration Inosine - analogs & derivatives Kinetics Membrane Proteins - metabolism Nucleoside Transport Proteins Thioinosine - analogs & derivatives Thioinosine - pharmacology Thionucleosides - pharmacology
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