Long-term neuropsychologic sequelae of childhood leukemia: Correlation with CT brain scan abnormalities
Previous studies have failed to establish a direct relationship between behavioral disorders and organic pathology in long-term survivors of childhood acute lymphoblastic leukemia. We evaluated 23 long-term survivors who received central nervous system preventive therapy with cranial irradiation and...
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| Veröffentlicht in: | The Journal of pediatrics 1985-05, Vol.106 (5), p.723-728 |
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| container_title | The Journal of pediatrics |
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| creator | Brouwers, Pim Riccardi, Riccardo Fedio, Paul Poplack, David G. |
| description | Previous studies have failed to establish a direct relationship between behavioral disorders and organic pathology in long-term survivors of childhood acute lymphoblastic leukemia. We evaluated 23 long-term survivors who received central nervous system preventive therapy with cranial irradiation and intrathecal chemotherapy, using neuropsychologic tests and computed tomographic brain scans. The patients were in continuous first remission for 7 to 11 years, and none were receiving chemotherapy. On the basis of their CT scan findings, they were divided into three groups: 10 with normal CT findings, five with intracerebral calcifications, and eight with cortical atrophy. Neuropsychologic test results allowed prediction of CT scan findings with an 87% accuracy (P |
| doi_str_mv | 10.1016/S0022-3476(85)80343-7 |
| format | Article |
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We evaluated 23 long-term survivors who received central nervous system preventive therapy with cranial irradiation and intrathecal chemotherapy, using neuropsychologic tests and computed tomographic brain scans. The patients were in continuous first remission for 7 to 11 years, and none were receiving chemotherapy. On the basis of their CT scan findings, they were divided into three groups: 10 with normal CT findings, five with intracerebral calcifications, and eight with cortical atrophy. Neuropsychologic test results allowed prediction of CT scan findings with an 87% accuracy (P<0.001), indicating a strong correlation between the presence and type of CT scan abnormality and neuropsychologic functioning. 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We evaluated 23 long-term survivors who received central nervous system preventive therapy with cranial irradiation and intrathecal chemotherapy, using neuropsychologic tests and computed tomographic brain scans. The patients were in continuous first remission for 7 to 11 years, and none were receiving chemotherapy. On the basis of their CT scan findings, they were divided into three groups: 10 with normal CT findings, five with intracerebral calcifications, and eight with cortical atrophy. Neuropsychologic test results allowed prediction of CT scan findings with an 87% accuracy (P<0.001), indicating a strong correlation between the presence and type of CT scan abnormality and neuropsychologic functioning. Tests that measured verbal memory, attention, and functions correlated with frontal lobe integrity were most powerful in discriminating between groups.</description><subject>Adolescent</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cognition Disorders - diagnosis</subject><subject>Cognition Disorders - etiology</subject><subject>Cognition Disorders - prevention & control</subject><subject>Communication Disorders - diagnosis</subject><subject>Communication Disorders - etiology</subject><subject>Communication Disorders - prevention & control</subject><subject>Cytarabine - therapeutic use</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Leukemia, Lymphoid - complications</subject><subject>Leukemia, Lymphoid - drug therapy</subject><subject>Male</subject><subject>Mercaptopurine - administration & dosage</subject><subject>Methotrexate - administration & dosage</subject><subject>Methotrexate - therapeutic use</subject><subject>Neuropsychological Tests</subject><subject>Prednisone - administration & dosage</subject><subject>Tomography, X-Ray Computed</subject><subject>Vincristine - administration & dosage</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EKqXwCZW8QrAIOHbsOGwQqnhJlVhQ1pbjTFpDEhc7AfH3mLbqltWMdO887kFompKrlKTi-pUQShOW5eJC8ktJWMaS_ACNU1LkiZCMHaLx3nKMTkJ4J4QUGSEjNGKSy6ygY7Scu26Z9OBb3MHg3Tr8mJVr3NIaHOBzgEYDdjU2K9tUK-cq3MDwAa3VN3jmvI96b12Hv22_wrMFLr22HQ5Gd1iXnfOtbmxvIZyio1o3Ac52dYLeHu4Xs6dk_vL4PLubJ4YJ0ie1qUUliJSMG4hJqhwEgCRUltxktDaxLSSFtMgEjUajKRGcgi5FXUnK2ASdb_euvYvfh161NhhoGt2BG4LKRUp5ymk08q3ReBeCh1qtvW21_1EpUX-A1Qaw-qOnJFcbwCqPc9PdgaFsodpP7YhG_XarQ0z5ZcGrYCx0BirrwfSqcvafC7-_Bovr</recordid><startdate>198505</startdate><enddate>198505</enddate><creator>Brouwers, Pim</creator><creator>Riccardi, Riccardo</creator><creator>Fedio, Paul</creator><creator>Poplack, David G.</creator><general>Mosby, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198505</creationdate><title>Long-term neuropsychologic sequelae of childhood leukemia: Correlation with CT brain scan abnormalities</title><author>Brouwers, Pim ; 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| subjects | Adolescent Antineoplastic Combined Chemotherapy Protocols - therapeutic use Child Child, Preschool Cognition Disorders - diagnosis Cognition Disorders - etiology Cognition Disorders - prevention & control Communication Disorders - diagnosis Communication Disorders - etiology Communication Disorders - prevention & control Cytarabine - therapeutic use Female Follow-Up Studies Humans Leukemia, Lymphoid - complications Leukemia, Lymphoid - drug therapy Male Mercaptopurine - administration & dosage Methotrexate - administration & dosage Methotrexate - therapeutic use Neuropsychological Tests Prednisone - administration & dosage Tomography, X-Ray Computed Vincristine - administration & dosage |
| title | Long-term neuropsychologic sequelae of childhood leukemia: Correlation with CT brain scan abnormalities |
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