Changes in evoked potentials and amino acid content during fluorocitrate action studied in rat hippocampal cortex
Fluorocitrate inhibits the glial tricarboxylic acid cycle and thereby the synthesis of glutamine, which is the main precursor for transmitter glutamate. We investigated the possibility that there is a functional correlate to fluorocitrate action by recording evoked field potentials in rat hippocampa...
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| Veröffentlicht in: | Experimental brain research 1993-10, Vol.96 (2), p.241-246 |
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| creator | BERG-JOHNSEN, J PAULSEN, R. E FONNUM, F LANGMOEN, I. A |
| description | Fluorocitrate inhibits the glial tricarboxylic acid cycle and thereby the synthesis of glutamine, which is the main precursor for transmitter glutamate. We investigated the possibility that there is a functional correlate to fluorocitrate action by recording evoked field potentials in rat hippocampal slices. The excitatory postsynaptic potential (field-EPSP) was markedly depressed after 7-8 h of fluorocitrate action. The population spike was also reduced, but a major part of the reduction may be the result of weaker synaptic activation rather than reduced excitability of the postsynaptic cells. The activity of thin unmyelinated fibres was only slightly affected. Preceding the changes in the field-EPSP there was a decrease in the glutamine content in the fluorocitrate treated slices relative to controls. Only a small decrease in tissue glutamate was seen concomitantly with the synaptic failure, probably because the transmitter pool of glutamate in those fibres stimulated makes little contribution to the total tissue glutamate. |
| doi_str_mv | 10.1007/BF00227104 |
| format | Article |
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Psychology</topic><topic>Glutamates - metabolism</topic><topic>Glutamic Acid</topic><topic>Glutamine - metabolism</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - metabolism</topic><topic>Hippocampus - physiology</topic><topic>In Vitro Techniques</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Synapses - drug effects</topic><topic>Synapses - physiology</topic><topic>Taurine - metabolism</topic><topic>Time Factors</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BERG-JOHNSEN, J</creatorcontrib><creatorcontrib>PAULSEN, R. E</creatorcontrib><creatorcontrib>FONNUM, F</creatorcontrib><creatorcontrib>LANGMOEN, I. 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A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in evoked potentials and amino acid content during fluorocitrate action studied in rat hippocampal cortex</atitle><jtitle>Experimental brain research</jtitle><addtitle>Exp Brain Res</addtitle><date>1993-10-01</date><risdate>1993</risdate><volume>96</volume><issue>2</issue><spage>241</spage><epage>246</epage><pages>241-246</pages><issn>0014-4819</issn><eissn>1432-1106</eissn><coden>EXBRAP</coden><abstract>Fluorocitrate inhibits the glial tricarboxylic acid cycle and thereby the synthesis of glutamine, which is the main precursor for transmitter glutamate. We investigated the possibility that there is a functional correlate to fluorocitrate action by recording evoked field potentials in rat hippocampal slices. The excitatory postsynaptic potential (field-EPSP) was markedly depressed after 7-8 h of fluorocitrate action. 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| ispartof | Experimental brain research, 1993-10, Vol.96 (2), p.241-246 |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Adenosine Triphosphate - metabolism Alanine - metabolism Amino Acids - metabolism Animals Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Citrates - pharmacology Electric Stimulation Evoked Potentials - drug effects Fundamental and applied biological sciences. Psychology Glutamates - metabolism Glutamic Acid Glutamine - metabolism Hippocampus - drug effects Hippocampus - metabolism Hippocampus - physiology In Vitro Techniques Rats Rats, Wistar Synapses - drug effects Synapses - physiology Taurine - metabolism Time Factors Vertebrates: nervous system and sense organs |
| title | Changes in evoked potentials and amino acid content during fluorocitrate action studied in rat hippocampal cortex |
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