Antioxidant and neutrophil-inhibiting properties of new 2-O-methyl-6-(alkylthio)ascorbic acid derivatives

A series of new 6-(alkylthio)ascorbic acids was synthesized, and their inhibitory effects on lipid peroxidation and the oxidative burst of human neutrophils were tested. Of 12 structurally different lipophilic ascorbic acid derivatives 6-S-n-hexadecyl-2-O-methyl-6-deoxy-6-thio-L-ascorbic acid (7b; B...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 1993-12, Vol.36 (25), p.4021-4029
Hauptverfasser:	Schmid, Elmar, Figala, Volker, Roth, Dagmar, Ullrich, Volker
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - chemical synthesis Antioxidants - chemistry Antioxidants - pharmacology Ascorbic Acid - analogs & derivatives Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Humans Lipid Peroxidation - drug effects Medical sciences Membrane Potentials - drug effects Microsomes, Liver - drug effects Microsomes, Liver - metabolism Neutrophils - drug effects Neutrophils - metabolism Pharmacology. Drug treatments Rats Rats, Wistar Respiratory Burst - drug effects Structure-Activity Relationship Superoxide Dismutase - biosynthesis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!