Nonspecific In Situ Hybridization Reaction in Neuroendocrine Cells and Tumors of the Gastrointestinal Tract Using Oligonucleotide Probes

Oligonucleotides used in in situ hybridization (ISH). regardless of their sequence specificity, bind to neuroendocrine (NE) cells in normal gastrointestinal mucosa and tumors. This nonspecific binding, presumably related to the presence in NE cells of hidden NH2groups of obscure origin, can be preve...

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Veröffentlicht in:	Diagnostic molecular pathology 1993-06, Vol.2 (2), p.125-130
Hauptverfasser:	Pagani, Alberto, Cerrato, Milena, Bussolati, Gianni, Path, F R. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Digestive System - chemistry Digestive System - cytology Gastrointestinal Neoplasms - chemistry Humans In Situ Hybridization - methods Molecular Sequence Data Neurosecretory Systems - chemistry Neurosecretory Systems - cytology Oligonucleotide Probes Sensitivity and Specificity
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