Circulating T-cell subsets in Guillain-Barré syndrome
We compared the distribution of circulating T-cell subsets within 2 weeks of onset of symptoms in 14 patients with acute Guillain-Barré syndrome (GBS) and 37 normal controls. The levels of OKT4 + (putative helper-inducer) cells was definitely abnormal (decreased) in 3/13 tested. The levels of OKT8 +...
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| Veröffentlicht in: | Journal of neuroimmunology 1985-01, Vol.8 (2-3), p.93-101 |
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| creator | Lisak, Robert P. Zweiman, Burton Guerrero, Feli Moskovitz, Anne R. |
| description | We compared the distribution of circulating T-cell subsets within 2 weeks of onset of symptoms in 14 patients with acute Guillain-Barré syndrome (GBS) and 37 normal controls. The levels of OKT4
+ (putative helper-inducer) cells was definitely abnormal (decreased) in 3/13 tested. The levels of OKT8
+ (putative suppressor-cytotoxic) cells were elevated in 3 and decreased in 2 of the 14 tested. Abnormal OKT4/OKT8 ratios were detected in 5 (2 elevated and 3 decreased) patients. Four of the 5 GBS patients with abnormal OKT4
+/OKT8
+ ratios were studied sequentially at least 4 times over 1–10 months; there was a return towards a normal ratio in all. Serial studies in 3 other GBS patients showed consistently normal values. In comparison, sequential studies over 5–24 months in 7 normals showed no abnormal OKT4
+/OKT8
+ ratios. Thus, abnormalities in OKT4
+/OKT8
+ ratios appear to be a marker of systemic events during symptomatic phases of GBS. It is not as yet known whether this is related to the cause or is secondary to the clinical manifestations of GBS. |
| doi_str_mv | 10.1016/S0165-5728(85)80050-3 |
| format | Article |
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+ (putative helper-inducer) cells was definitely abnormal (decreased) in 3/13 tested. The levels of OKT8
+ (putative suppressor-cytotoxic) cells were elevated in 3 and decreased in 2 of the 14 tested. Abnormal OKT4/OKT8 ratios were detected in 5 (2 elevated and 3 decreased) patients. Four of the 5 GBS patients with abnormal OKT4
+/OKT8
+ ratios were studied sequentially at least 4 times over 1–10 months; there was a return towards a normal ratio in all. Serial studies in 3 other GBS patients showed consistently normal values. In comparison, sequential studies over 5–24 months in 7 normals showed no abnormal OKT4
+/OKT8
+ ratios. Thus, abnormalities in OKT4
+/OKT8
+ ratios appear to be a marker of systemic events during symptomatic phases of GBS. It is not as yet known whether this is related to the cause or is secondary to the clinical manifestations of GBS.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/S0165-5728(85)80050-3</identifier><identifier>PMID: 3158670</identifier><identifier>CODEN: JNRIDW</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Antibodies, Monoclonal ; Biological and medical sciences ; Guillain-Barré syndrome ; Humans ; Medical sciences ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis ; Neurology ; OKT4 + cells ; OKT8 + cells ; Polyradiculoneuropathy - blood ; Polyradiculoneuropathy - immunology ; T-cell subsets ; T-Lymphocytes - classification ; T-Lymphocytes, Cytotoxic - immunology ; T-Lymphocytes, Helper-Inducer - immunology ; T-Lymphocytes, Regulatory - immunology</subject><ispartof>Journal of neuroimmunology, 1985-01, Vol.8 (2-3), p.93-101</ispartof><rights>1985 Elsevier Science Publishers (Biomedical Division) All rights reserved</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-77259aea12494e31db61b3bef0964fe4024a326f1963386f82a320826bde93e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165572885800503$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9159028$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3158670$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lisak, Robert P.</creatorcontrib><creatorcontrib>Zweiman, Burton</creatorcontrib><creatorcontrib>Guerrero, Feli</creatorcontrib><creatorcontrib>Moskovitz, Anne R.</creatorcontrib><title>Circulating T-cell subsets in Guillain-Barré syndrome</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>We compared the distribution of circulating T-cell subsets within 2 weeks of onset of symptoms in 14 patients with acute Guillain-Barré syndrome (GBS) and 37 normal controls. The levels of OKT4
+ (putative helper-inducer) cells was definitely abnormal (decreased) in 3/13 tested. The levels of OKT8
+ (putative suppressor-cytotoxic) cells were elevated in 3 and decreased in 2 of the 14 tested. Abnormal OKT4/OKT8 ratios were detected in 5 (2 elevated and 3 decreased) patients. Four of the 5 GBS patients with abnormal OKT4
+/OKT8
+ ratios were studied sequentially at least 4 times over 1–10 months; there was a return towards a normal ratio in all. Serial studies in 3 other GBS patients showed consistently normal values. In comparison, sequential studies over 5–24 months in 7 normals showed no abnormal OKT4
+/OKT8
+ ratios. Thus, abnormalities in OKT4
+/OKT8
+ ratios appear to be a marker of systemic events during symptomatic phases of GBS. It is not as yet known whether this is related to the cause or is secondary to the clinical manifestations of GBS.</description><subject>Antibodies, Monoclonal</subject><subject>Biological and medical sciences</subject><subject>Guillain-Barré syndrome</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Neurology</subject><subject>OKT4 + cells</subject><subject>OKT8 + cells</subject><subject>Polyradiculoneuropathy - blood</subject><subject>Polyradiculoneuropathy - immunology</subject><subject>T-cell subsets</subject><subject>T-Lymphocytes - classification</subject><subject>T-Lymphocytes, Cytotoxic - immunology</subject><subject>T-Lymphocytes, Helper-Inducer - immunology</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1Kw0AQgBdRaq0-QiEHET1E9z-7J9GiVSh4sPdls5nISprU3UToI_kcvphJW3r1MsMw3_zwITQl-JZgIu_e-yBSkVF1rcSNwljglB2hMVEZTRWn5BiND8gpOovxE2MiGNcjNGJEKJnhMZIzH1xX2dbXH8kydVBVSezyCG1MfJ3MO19V1tfpow3h9yeJm7oIzQrO0UlpqwgX-zxBy-en5ewlXbzNX2cPi9Rxrts0y6jQFiyhXHNgpMglyVkOJdaSl8Ax5ZZRWRItGVOyVLQvsaIyL0AzYBN0tVu7Ds1XB7E1Kx-HH20NTRdNJgllLKP_goQTITPOelDsQBeaGAOUZh38yoaNIdgMXs3WqxmkGSXM1qsZ5qb7A12-guIwtRfZ9y_3fRudrcpga-fjAdNEaExVj93vMOilfXsIJjoPtYPCB3CtKRr_zyN_pWGStw</recordid><startdate>19850101</startdate><enddate>19850101</enddate><creator>Lisak, Robert P.</creator><creator>Zweiman, Burton</creator><creator>Guerrero, Feli</creator><creator>Moskovitz, Anne R.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19850101</creationdate><title>Circulating T-cell subsets in Guillain-Barré syndrome</title><author>Lisak, Robert P. ; Zweiman, Burton ; Guerrero, Feli ; Moskovitz, Anne R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-77259aea12494e31db61b3bef0964fe4024a326f1963386f82a320826bde93e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Antibodies, Monoclonal</topic><topic>Biological and medical sciences</topic><topic>Guillain-Barré syndrome</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</topic><topic>Neurology</topic><topic>OKT4 + cells</topic><topic>OKT8 + cells</topic><topic>Polyradiculoneuropathy - blood</topic><topic>Polyradiculoneuropathy - immunology</topic><topic>T-cell subsets</topic><topic>T-Lymphocytes - classification</topic><topic>T-Lymphocytes, Cytotoxic - immunology</topic><topic>T-Lymphocytes, Helper-Inducer - immunology</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lisak, Robert P.</creatorcontrib><creatorcontrib>Zweiman, Burton</creatorcontrib><creatorcontrib>Guerrero, Feli</creatorcontrib><creatorcontrib>Moskovitz, Anne R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lisak, Robert P.</au><au>Zweiman, Burton</au><au>Guerrero, Feli</au><au>Moskovitz, Anne R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating T-cell subsets in Guillain-Barré syndrome</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>1985-01-01</date><risdate>1985</risdate><volume>8</volume><issue>2-3</issue><spage>93</spage><epage>101</epage><pages>93-101</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><coden>JNRIDW</coden><abstract>We compared the distribution of circulating T-cell subsets within 2 weeks of onset of symptoms in 14 patients with acute Guillain-Barré syndrome (GBS) and 37 normal controls. The levels of OKT4
+ (putative helper-inducer) cells was definitely abnormal (decreased) in 3/13 tested. The levels of OKT8
+ (putative suppressor-cytotoxic) cells were elevated in 3 and decreased in 2 of the 14 tested. Abnormal OKT4/OKT8 ratios were detected in 5 (2 elevated and 3 decreased) patients. Four of the 5 GBS patients with abnormal OKT4
+/OKT8
+ ratios were studied sequentially at least 4 times over 1–10 months; there was a return towards a normal ratio in all. Serial studies in 3 other GBS patients showed consistently normal values. In comparison, sequential studies over 5–24 months in 7 normals showed no abnormal OKT4
+/OKT8
+ ratios. Thus, abnormalities in OKT4
+/OKT8
+ ratios appear to be a marker of systemic events during symptomatic phases of GBS. It is not as yet known whether this is related to the cause or is secondary to the clinical manifestations of GBS.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>3158670</pmid><doi>10.1016/S0165-5728(85)80050-3</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 0165-5728 |
| ispartof | Journal of neuroimmunology, 1985-01, Vol.8 (2-3), p.93-101 |
| issn | 0165-5728 1872-8421 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76123372 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Antibodies, Monoclonal Biological and medical sciences Guillain-Barré syndrome Humans Medical sciences Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology OKT4 + cells OKT8 + cells Polyradiculoneuropathy - blood Polyradiculoneuropathy - immunology T-cell subsets T-Lymphocytes - classification T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Regulatory - immunology |
| title | Circulating T-cell subsets in Guillain-Barré syndrome |
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