Chronic alpha-adrenoceptor blockade with trimazosin in congestive heart failure

We evaluated chronic adjunctive alpha-1 receptor blockade with trimazosin in congestive heart failure. This agent produced hemodynamic effects consistent with venodilation (reduced left ventricular volume and filling pressure with increased left ventricular ejection fraction), but only during exerci...

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Veröffentlicht in:	International journal of cardiology 1985-05, Vol.8 (1), p.89-92
Hauptverfasser:	Kirlin, Philip C., Das, Sunil, Pitt, Bertram
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-adrenoceptor blockade Biological and medical sciences Cardiovascular system Chronic Disease congestive heart failure exercise Exercise Test Heart Failure - drug therapy Hemodynamics - drug effects Humans Medical sciences Middle Aged Miscellaneous Pharmacology. Drug treatments Piperazines - therapeutic use Receptors, Adrenergic, alpha - drug effects trimazosin Vasodilator Agents - therapeutic use ventricular function
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Zusammenfassung:	We evaluated chronic adjunctive alpha-1 receptor blockade with trimazosin in congestive heart failure. This agent produced hemodynamic effects consistent with venodilation (reduced left ventricular volume and filling pressure with increased left ventricular ejection fraction), but only during exercise. Resting hemodynamic parameters and exercise duration were not significantly altered by chronic alpha-1 receptor blockade.
ISSN:	0167-5273 1874-1754
DOI:	10.1016/0167-5273(85)90267-0