The development of behavioral sensitization to apomorphine is blocked by MK-801
The effects of the non-competitive NMDA receptor antagonist, MK-801 (dizocilpine), on the development of sensitization to the mixed dopamine receptor agonist, apomorphine were examined. Rats pretreated with MK-801 (0.25 mg/kg) prior to 2.0 mg/kg apomorphine failed to show a progressive sensitization...
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| Veröffentlicht in: | European journal of pharmacology 1993-10, Vol.243 (1), p.73-77 |
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| container_end_page | 77 |
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| container_title | European journal of pharmacology |
| container_volume | 243 |
| creator | Druhan, Jonathan P. Jakob, Andrea Stewart, Jane |
| description | The effects of the non-competitive NMDA receptor antagonist, MK-801 (dizocilpine), on the development of sensitization to the mixed dopamine receptor agonist, apomorphine were examined. Rats pretreated with MK-801 (0.25 mg/kg) prior to 2.0 mg/kg apomorphine failed to show a progressive sensitization to the activating effect of apomorphine across six preexposure sessions, nor did they show enhanced activity relative to control rats in response to 0.5 mg/kg apomorphine, given alone, during a subsequent test for sensitization. These results support the view that MK-801 interferes with long-term neural changes underlying sensitization to stimulant drugs. |
| doi_str_mv | 10.1016/0014-2999(93)90169-I |
| format | Article |
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Rats pretreated with MK-801 (0.25 mg/kg) prior to 2.0 mg/kg apomorphine failed to show a progressive sensitization to the activating effect of apomorphine across six preexposure sessions, nor did they show enhanced activity relative to control rats in response to 0.5 mg/kg apomorphine, given alone, during a subsequent test for sensitization. These results support the view that MK-801 interferes with long-term neural changes underlying sensitization to stimulant drugs.</description><subject>Animals</subject><subject>Apomorphine - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Conditioning (Psychology)</subject><subject>Dizocilpine Maleate - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Motor Activity - drug effects</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKxDAUhoMoOl7eQCELEV1Uc9r0ko0g4mVQcaPrkMspE22bmnQG9OntOMMsXR04_3d-Dh8hx8AugUFxxRjwJBVCnIvsQowbkUy3yASqUiSshHSbTDbIHtmP8YMxlos03yW7VZpnkJYT8vo2Q2pxgY3vW-wG6muqcaYWzgfV0IhddIP7UYPzHR08Vb1vfehnrkPqItWNN59oqf6mL09JxeCQ7NSqiXi0ngfk_f7u7fYxeX59mN7ePCeGZ-WQKC00VpZnWtfWWKhyVSCYwgBqBGULDYYhT2Fc8gozXiOzFdS1KJADs9kBOVv19sF_zTEOsnXRYNOoDv08yrIAEKIoR5CvQBN8jAFr2QfXqvAtgcmlR7mUJJeSpMjkn0c5Hc9O1v1z3aLdHK3FjfnpOlfRqKYOqjMubjAuIM8LMWLXKwxHFwuHQUbjsDNoXUAzSOvd_3_8Aspmj6E</recordid><startdate>19931012</startdate><enddate>19931012</enddate><creator>Druhan, Jonathan P.</creator><creator>Jakob, Andrea</creator><creator>Stewart, Jane</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19931012</creationdate><title>The development of behavioral sensitization to apomorphine is blocked by MK-801</title><author>Druhan, Jonathan P. ; Jakob, Andrea ; Stewart, Jane</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-ab9be8d43bbfdcd185a6e1c6c1ebe1ad6b1c0e421e1c48e34fe0d81ff96e410d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Apomorphine - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Conditioning (Psychology)</topic><topic>Dizocilpine Maleate - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Motor Activity - drug effects</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Druhan, Jonathan P.</creatorcontrib><creatorcontrib>Jakob, Andrea</creatorcontrib><creatorcontrib>Stewart, Jane</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Druhan, Jonathan P.</au><au>Jakob, Andrea</au><au>Stewart, Jane</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The development of behavioral sensitization to apomorphine is blocked by MK-801</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1993-10-12</date><risdate>1993</risdate><volume>243</volume><issue>1</issue><spage>73</spage><epage>77</epage><pages>73-77</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>The effects of the non-competitive NMDA receptor antagonist, MK-801 (dizocilpine), on the development of sensitization to the mixed dopamine receptor agonist, apomorphine were examined. 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| fulltext | fulltext |
| identifier | ISSN: 0014-2999 |
| ispartof | European journal of pharmacology, 1993-10, Vol.243 (1), p.73-77 |
| issn | 0014-2999 1879-0712 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Apomorphine - pharmacology Biological and medical sciences Conditioning (Psychology) Dizocilpine Maleate - pharmacology Male Medical sciences Motor Activity - drug effects Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Wistar |
| title | The development of behavioral sensitization to apomorphine is blocked by MK-801 |
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