Brain Gangliosides of Quaking and Shiverer Mutants: Qualitative and Quantitative Changes of Monosialogangliosides in the Quaking Brain
: Ganglioside compositions in the brains of the mutant mice quaking and shiverer were compared with those of their littermate controls, C57BL/6 and C3HSWV. Neither ganglioside content nor composition of shiverer brains differed from those of the control brains. Change in the ganglioside composition...
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| Veröffentlicht in: | Journal of neurochemistry 1985-07, Vol.45 (1), p.73-78 |
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| container_title | Journal of neurochemistry |
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| creator | Iwamori, Masao Harpin, Marie‐Luce Lachapelle, Francois Baumann, Nicole |
| description | : Ganglioside compositions in the brains of the mutant mice quaking and shiverer were compared with those of their littermate controls, C57BL/6 and C3HSWV. Neither ganglioside content nor composition of shiverer brains differed from those of the control brains. Change in the ganglioside composition of the mutant brain from that of the control was observed only in the quaking mutant brain, in which monosialoganglioside GM1 was significantly reduced and GM4 was completely absent. The structures of the gangliosides were determined by negative ion fast atom bombardment mass spectrometry, and the GM3 and GM4 gangliosides in the quaking brain were found to be altered in regard to their long‐chain base and fatty acid compositions when compared to the normal C57BL/6 brain. |
| doi_str_mv | 10.1111/j.1471-4159.1985.tb05476.x |
| format | Article |
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Neither ganglioside content nor composition of shiverer brains differed from those of the control brains. Change in the ganglioside composition of the mutant brain from that of the control was observed only in the quaking mutant brain, in which monosialoganglioside GM1 was significantly reduced and GM4 was completely absent. The structures of the gangliosides were determined by negative ion fast atom bombardment mass spectrometry, and the GM3 and GM4 gangliosides in the quaking brain were found to be altered in regard to their long‐chain base and fatty acid compositions when compared to the normal C57BL/6 brain.</description><identifier>ISSN: 0022-3042</identifier><identifier>EISSN: 1471-4159</identifier><identifier>DOI: 10.1111/j.1471-4159.1985.tb05476.x</identifier><identifier>PMID: 3998734</identifier><identifier>CODEN: JONRA9</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Biochemistry and metabolism ; Biological and medical sciences ; Brain - metabolism ; Central nervous system ; Chromatography, Thin Layer ; Fatty Acids - metabolism ; Fundamental and applied biological sciences. Psychology ; G(M1) Ganglioside - metabolism ; G(M2) Ganglioside - metabolism ; G(M3) Ganglioside - metabolism ; Ganglioside ; Gangliosides - metabolism ; Humans ; Mass Spectrometry ; Mice ; Mice, Inbred C3H ; Mice, Inbred C57BL ; Mice, Neurologic Mutants ; Mice, Quaking ; Mutant mice ; Negative ion fast atom bombardment mass spectrometry ; Vertebrates: nervous system and sense organs</subject><ispartof>Journal of neurochemistry, 1985-07, Vol.45 (1), p.73-78</ispartof><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4283-c2d93d49324ef51d795aa5a10353726fdcfce47fbec0234cd9d7ef8e76b74c203</citedby><cites>FETCH-LOGICAL-c4283-c2d93d49324ef51d795aa5a10353726fdcfce47fbec0234cd9d7ef8e76b74c203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1471-4159.1985.tb05476.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1471-4159.1985.tb05476.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9206349$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3998734$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iwamori, Masao</creatorcontrib><creatorcontrib>Harpin, Marie‐Luce</creatorcontrib><creatorcontrib>Lachapelle, Francois</creatorcontrib><creatorcontrib>Baumann, Nicole</creatorcontrib><title>Brain Gangliosides of Quaking and Shiverer Mutants: Qualitative and Quantitative Changes of Monosialogangliosides in the Quaking Brain</title><title>Journal of neurochemistry</title><addtitle>J Neurochem</addtitle><description>: Ganglioside compositions in the brains of the mutant mice quaking and shiverer were compared with those of their littermate controls, C57BL/6 and C3HSWV. Neither ganglioside content nor composition of shiverer brains differed from those of the control brains. Change in the ganglioside composition of the mutant brain from that of the control was observed only in the quaking mutant brain, in which monosialoganglioside GM1 was significantly reduced and GM4 was completely absent. The structures of the gangliosides were determined by negative ion fast atom bombardment mass spectrometry, and the GM3 and GM4 gangliosides in the quaking brain were found to be altered in regard to their long‐chain base and fatty acid compositions when compared to the normal C57BL/6 brain.</description><subject>Animals</subject><subject>Biochemistry and metabolism</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Central nervous system</subject><subject>Chromatography, Thin Layer</subject><subject>Fatty Acids - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>G(M1) Ganglioside - metabolism</subject><subject>G(M2) Ganglioside - metabolism</subject><subject>G(M3) Ganglioside - metabolism</subject><subject>Ganglioside</subject><subject>Gangliosides - metabolism</subject><subject>Humans</subject><subject>Mass Spectrometry</subject><subject>Mice</subject><subject>Mice, Inbred C3H</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Neurologic Mutants</subject><subject>Mice, Quaking</subject><subject>Mutant mice</subject><subject>Negative ion fast atom bombardment mass spectrometry</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0022-3042</issn><issn>1471-4159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVUctOGzEUtaoimoZ-QqURqtjN1K8Zx0gsSsSjiIcQ7dpy_EgcJh5qz1D4Ab4bDxkidghvLN9z7jnX9wCwi2CB0vm5LBBlKKeo5AXik7JoZ7CkrCoePoHRBvoMRhBinBNI8RfwNcYlhKiiFdoG24TzCSN0BJ4Og3Q-O5F-XrsmOm1i1tjsupO3zs8z6XV2s3D3JpiQXXSt9G3c79HatbJN9RdGevv2tTBdJK21ykXjk6Ssm_lb-WTXLszG4mWAHbBlZR3Nt-Eeg7_HR3-mp_n51cnv6a_zXFE8IbnCmhNNOcHU2BJpxkspS4kgKQnDldXKKkOZnRkFMaFKc82MnRhWzRhVGJIx2Fvr3oXmX2diK1YuKlPX0pumi4JVCPWbeZeIKIYc8SoR99dEFZoYg7HiLriVDI8CQdGnJZaij0T0kYg-LTGkJR5S8_fBpZutjN60DvEk_MeAy6hkbYP0ysUNjWNYkbSNMThY0_672jx-YABxdjlNn30Gj1qzsQ</recordid><startdate>198507</startdate><enddate>198507</enddate><creator>Iwamori, Masao</creator><creator>Harpin, Marie‐Luce</creator><creator>Lachapelle, Francois</creator><creator>Baumann, Nicole</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>198507</creationdate><title>Brain Gangliosides of Quaking and Shiverer Mutants: Qualitative and Quantitative Changes of Monosialogangliosides in the Quaking Brain</title><author>Iwamori, Masao ; Harpin, Marie‐Luce ; Lachapelle, Francois ; Baumann, Nicole</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4283-c2d93d49324ef51d795aa5a10353726fdcfce47fbec0234cd9d7ef8e76b74c203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Biochemistry and metabolism</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Central nervous system</topic><topic>Chromatography, Thin Layer</topic><topic>Fatty Acids - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>G(M1) Ganglioside - metabolism</topic><topic>G(M2) Ganglioside - metabolism</topic><topic>G(M3) Ganglioside - metabolism</topic><topic>Ganglioside</topic><topic>Gangliosides - metabolism</topic><topic>Humans</topic><topic>Mass Spectrometry</topic><topic>Mice</topic><topic>Mice, Inbred C3H</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Neurologic Mutants</topic><topic>Mice, Quaking</topic><topic>Mutant mice</topic><topic>Negative ion fast atom bombardment mass spectrometry</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iwamori, Masao</creatorcontrib><creatorcontrib>Harpin, Marie‐Luce</creatorcontrib><creatorcontrib>Lachapelle, Francois</creatorcontrib><creatorcontrib>Baumann, Nicole</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iwamori, Masao</au><au>Harpin, Marie‐Luce</au><au>Lachapelle, Francois</au><au>Baumann, Nicole</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain Gangliosides of Quaking and Shiverer Mutants: Qualitative and Quantitative Changes of Monosialogangliosides in the Quaking Brain</atitle><jtitle>Journal of neurochemistry</jtitle><addtitle>J Neurochem</addtitle><date>1985-07</date><risdate>1985</risdate><volume>45</volume><issue>1</issue><spage>73</spage><epage>78</epage><pages>73-78</pages><issn>0022-3042</issn><eissn>1471-4159</eissn><coden>JONRA9</coden><abstract>: Ganglioside compositions in the brains of the mutant mice quaking and shiverer were compared with those of their littermate controls, C57BL/6 and C3HSWV. Neither ganglioside content nor composition of shiverer brains differed from those of the control brains. Change in the ganglioside composition of the mutant brain from that of the control was observed only in the quaking mutant brain, in which monosialoganglioside GM1 was significantly reduced and GM4 was completely absent. The structures of the gangliosides were determined by negative ion fast atom bombardment mass spectrometry, and the GM3 and GM4 gangliosides in the quaking brain were found to be altered in regard to their long‐chain base and fatty acid compositions when compared to the normal C57BL/6 brain.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>3998734</pmid><doi>10.1111/j.1471-4159.1985.tb05476.x</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of neurochemistry, 1985-07, Vol.45 (1), p.73-78 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Biochemistry and metabolism Biological and medical sciences Brain - metabolism Central nervous system Chromatography, Thin Layer Fatty Acids - metabolism Fundamental and applied biological sciences. Psychology G(M1) Ganglioside - metabolism G(M2) Ganglioside - metabolism G(M3) Ganglioside - metabolism Ganglioside Gangliosides - metabolism Humans Mass Spectrometry Mice Mice, Inbred C3H Mice, Inbred C57BL Mice, Neurologic Mutants Mice, Quaking Mutant mice Negative ion fast atom bombardment mass spectrometry Vertebrates: nervous system and sense organs |
| title | Brain Gangliosides of Quaking and Shiverer Mutants: Qualitative and Quantitative Changes of Monosialogangliosides in the Quaking Brain |
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