RANDOMIZED TRIAL COMPARING CRYOPRESERVED CULTURED EPIDERMAL ALLOGRAFTS WITH TULLE-GRAS IN THE TREATMENT OF SPLIT-THICKNESS SKIN GRAFT DONOR SITES
Cultured epidermal allografts have been successfully used to treat a wide variety of skin defects ranging from burns to leg ulcers. Their postulated mechanism of action is through release of multiple cytokines that stimulate epithelialization from the wound periphery as well as from remnant epiderma...
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| Veröffentlicht in: | The Journal of trauma 1993-12, Vol.35 (6), p.850-854 |
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| container_title | The Journal of trauma |
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| creator | Teepe, Robert G. C. Koch, Richard Haeseker, Barend |
| description | Cultured epidermal allografts have been successfully used to treat a wide variety of skin defects ranging from burns to leg ulcers. Their postulated mechanism of action is through release of multiple cytokines that stimulate epithelialization from the wound periphery as well as from remnant epidermal appendages. A randomized, controlled clinical trial was undertaken to compare the efficacy of cryopreserved cultured allograft dressings (CCAD) with tulle-gras dressings in the treatment of splitskin graft donor sites. Five patients were enrolled in the study and in each patient, half of the donor site was allografted and the other half was treated with tulle-gras control. The mean time to complete healing was 6.2 days for CCAD compared with 9.6 days (p = 0.035) for the tulle-gras controls. Patient assessment of pain with dressing changes was also significantly lower at the CCAD treated sites than at the control sites (p = 0.001). The results indicate that cultured allografts offer greater patient comfort and earlier maturation of regenerated skin. |
| doi_str_mv | 10.1097/00005373-199312000-00008 |
| format | Article |
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Patient assessment of pain with dressing changes was also significantly lower at the CCAD treated sites than at the control sites (p = 0.001). 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The results indicate that cultured allografts offer greater patient comfort and earlier maturation of regenerated skin.</description><subject>Adult</subject><subject>Aged</subject><subject>Anti-Infective Agents, Local - therapeutic use</subject><subject>Bandages - standards</subject><subject>Biological and medical sciences</subject><subject>Biological Dressings - standards</subject><subject>Cryopreservation - methods</subject><subject>Culture Techniques</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pain - epidemiology</subject><subject>Pain - etiology</subject><subject>Pain Measurement</subject><subject>Phenols - therapeutic use</subject><subject>Prospective Studies</subject><subject>Single-Blind Method</subject><subject>Skin plastic surgery</subject><subject>Skin Transplantation - methods</subject><subject>Surgery (general aspects). 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| identifier | ISSN: 0022-5282 |
| ispartof | The Journal of trauma, 1993-12, Vol.35 (6), p.850-854 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Aged Anti-Infective Agents, Local - therapeutic use Bandages - standards Biological and medical sciences Biological Dressings - standards Cryopreservation - methods Culture Techniques Female Humans Incidence Male Medical sciences Middle Aged Pain - epidemiology Pain - etiology Pain Measurement Phenols - therapeutic use Prospective Studies Single-Blind Method Skin plastic surgery Skin Transplantation - methods Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgical Wound Infection - epidemiology Surgical Wound Infection - etiology Tissue Donors Wound Healing |
| title | RANDOMIZED TRIAL COMPARING CRYOPRESERVED CULTURED EPIDERMAL ALLOGRAFTS WITH TULLE-GRAS IN THE TREATMENT OF SPLIT-THICKNESS SKIN GRAFT DONOR SITES |
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