Synthesis, antiproliferative, and antiviral activity of 4-amino-1-(.beta.-D-ribofuranosyl)pyrrolo[2,3-d]pyridazin-7(6H)-one and related derivatives

The synthesis of 4-amino-1-beta-D-ribofuranosylpyrrolo[2,3-d]pyridazin-7 (6H)-one (3) from the reaction of ethyl 3-cyano-1-beta-D-ribofuranosylpyrrole-2-carboxylate (10) and hydrazine is described. The 5:6 pyrrolo[2,3-d]pyridazin-7(6H)-one structure of 3 was established via a three-step conversion o...

Ausführliche Beschreibung