Animal Models for Protecting Ischemic Myocardium: Results of the NHLBI Cooperative Study: Comparison of Unconscious and Conscious Dog Models

The Animal Models for Protecting Ischemic Myocardium Study was undertaken for the purpose of developing reproducible animal models that could be used to assess interventions designed to limit infarct size. This paper describes the results obtained in an unconscious dog model and in a conscious dog m...

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Veröffentlicht in:	Circulation research 1985-05, Vol.56 (5), p.651-665
Hauptverfasser:	Reimer, Keith A, Jennings, Robert B, Cobb, Fred R, Murdock, Robert H, Greenfield, Joseph C, Becker, Lewis C, Bulkley, Bernadine Healy, Hutchins, Grover M, Schwartz, Richard P, Bailey, Kent R, Passamani, Eugene R
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Animal Testing Alternatives Animals Antianginal agents. Coronary vasodilator agents Arterial Occlusive Diseases - physiopathology Biological and medical sciences Cardiovascular system Coronary Circulation - drug effects Coronary Disease - drug therapy Coronary Disease - mortality Coronary Disease - physiopathology Disease Models, Animal Dogs Female Hemodynamics - drug effects Humans Ibuprofen - therapeutic use Male Medical sciences Myocardial Infarction - drug therapy Myocardial Infarction - physiopathology National Institutes of Health (U.S.) Pharmacology. Drug treatments Random Allocation United States Verapamil - therapeutic use
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