Hormonal parameters of men with varicoceles before and after varicocelectomy
The gonadotropin responses to a 4-hour infusion of gonadotropin-releasing hormone (GnRH) and seminal plasma dihydrotestosterone (DHT) and testosterone levels were assessed before and 6 to 12 months after varicocelectomy in 22 men with varicoceles. Twelve men were severely Oligozoospermie (sperm dens...
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| Veröffentlicht in: | Fertility and sterility 1985-06, Vol.43 (6), p.905-910 |
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| container_issue | 6 |
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| container_title | Fertility and sterility |
| container_volume | 43 |
| creator | Hudson, Robert W. Perez-Marrero, Ramon A. Crawford, Vinton A. McKay, David E. |
| description | The gonadotropin responses to a 4-hour infusion of gonadotropin-releasing hormone (GnRH) and seminal plasma dihydrotestosterone (DHT) and testosterone levels were assessed before and 6 to 12 months after varicocelectomy in 22 men with varicoceles. Twelve men were severely Oligozoospermie (sperm densities |
| doi_str_mv | 10.1016/S0015-0282(16)48620-6 |
| format | Article |
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These results indicate that the pantesticular defect in hormonal synthesis and spermatogenesis, seen in some men with varicoceles, can be reversible.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/S0015-0282(16)48620-6</identifier><identifier>PMID: 3922807</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Birth control ; Dihydrotestosterone - blood ; Estradiol - blood ; Follicle Stimulating Hormone - blood ; Gonadotropin-Releasing Hormone ; Gynecology. Andrology. Obstetrics ; Humans ; Luteinizing Hormone - blood ; Male ; Medical sciences ; Oligospermia - blood ; Oligospermia - etiology ; Semen - analysis ; Sperm Count ; Sterility. Assisted procreation ; Testosterone - blood ; Varicocele - blood ; Varicocele - complications ; Varicocele - surgery</subject><ispartof>Fertility and sterility, 1985-06, Vol.43 (6), p.905-910</ispartof><rights>1985 American Society for Reproductive Medicine</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-acfb39d3cc9a62033c0dad96b85d5a3e052d5aa31e0f744b26cc6fdee3797ac3</citedby><cites>FETCH-LOGICAL-c436t-acfb39d3cc9a62033c0dad96b85d5a3e052d5aa31e0f744b26cc6fdee3797ac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0015-0282(16)48620-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8555474$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3922807$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hudson, Robert W.</creatorcontrib><creatorcontrib>Perez-Marrero, Ramon A.</creatorcontrib><creatorcontrib>Crawford, Vinton A.</creatorcontrib><creatorcontrib>McKay, David E.</creatorcontrib><title>Hormonal parameters of men with varicoceles before and after varicocelectomy</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>The gonadotropin responses to a 4-hour infusion of gonadotropin-releasing hormone (GnRH) and seminal plasma dihydrotestosterone (DHT) and testosterone levels were assessed before and 6 to 12 months after varicocelectomy in 22 men with varicoceles. Twelve men were severely Oligozoospermie (sperm densities<10 × 106/ml), whereas 10 men had sperm densities between 11 and 30 × 106/ml. Each man had excessive gonadotropin responses to GnRH and lower than normal seminal plasma DHT levels preoperatively. Eight of the 12 severely Oligozoospermie men and 6 of the other 10 men had postoperative improvements in sperm density. These men (responders) had normalization of gonadotropin response and seminal plasma DHT levels. The nonresponders had identical hormonal parameters before and after surgery.
These results indicate that the pantesticular defect in hormonal synthesis and spermatogenesis, seen in some men with varicoceles, can be reversible.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Birth control</subject><subject>Dihydrotestosterone - blood</subject><subject>Estradiol - blood</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Gonadotropin-Releasing Hormone</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Luteinizing Hormone - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Oligospermia - blood</subject><subject>Oligospermia - etiology</subject><subject>Semen - analysis</subject><subject>Sperm Count</subject><subject>Sterility. Assisted procreation</subject><subject>Testosterone - blood</subject><subject>Varicocele - blood</subject><subject>Varicocele - complications</subject><subject>Varicocele - surgery</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKxDAUhoMoOl4eQehCRBfVpGnSdiUyeIMBF7oPp8kJRtpmTDrKvL2ZC4M7V4fD_53k5yPknNEbRpm8faOUiZwWdXHF5HVZy4Lmco9MmBAyF1LwfTLZIUfkOMZPSqlkVXFIDnlTFDWtJmT27EPvB-iyOQToccQQM2-zHofsx40f2TcEp73GDmPWovUBMxhMBjaRf0I9-n55Sg4sdBHPtvOEvD8-vE-f89nr08v0fpbrkssxB21b3hiudQOpNeeaGjCNbGthBHCkokgTOENqq7JsC6m1tAaRV00Fmp-Qy82z8-C_FhhH1buYSnQwoF9EVUnGyorLBIoNqIOPMaBV8-B6CEvFqFpJVGuJamVIpW0tUa3uzrcfLNoeze5qay3lF9scoobOBhi0izusFkKUVZmwuw2GycW3w6CidjhoNC4kYcp490-RX1Lpjzc</recordid><startdate>198506</startdate><enddate>198506</enddate><creator>Hudson, Robert W.</creator><creator>Perez-Marrero, Ramon A.</creator><creator>Crawford, Vinton A.</creator><creator>McKay, David E.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198506</creationdate><title>Hormonal parameters of men with varicoceles before and after varicocelectomy</title><author>Hudson, Robert W. ; Perez-Marrero, Ramon A. ; Crawford, Vinton A. ; McKay, David E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-acfb39d3cc9a62033c0dad96b85d5a3e052d5aa31e0f744b26cc6fdee3797ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Birth control</topic><topic>Dihydrotestosterone - blood</topic><topic>Estradiol - blood</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Gonadotropin-Releasing Hormone</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Luteinizing Hormone - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Oligospermia - blood</topic><topic>Oligospermia - etiology</topic><topic>Semen - analysis</topic><topic>Sperm Count</topic><topic>Sterility. Assisted procreation</topic><topic>Testosterone - blood</topic><topic>Varicocele - blood</topic><topic>Varicocele - complications</topic><topic>Varicocele - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hudson, Robert W.</creatorcontrib><creatorcontrib>Perez-Marrero, Ramon A.</creatorcontrib><creatorcontrib>Crawford, Vinton A.</creatorcontrib><creatorcontrib>McKay, David E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hudson, Robert W.</au><au>Perez-Marrero, Ramon A.</au><au>Crawford, Vinton A.</au><au>McKay, David E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hormonal parameters of men with varicoceles before and after varicocelectomy</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>1985-06</date><risdate>1985</risdate><volume>43</volume><issue>6</issue><spage>905</spage><epage>910</epage><pages>905-910</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>The gonadotropin responses to a 4-hour infusion of gonadotropin-releasing hormone (GnRH) and seminal plasma dihydrotestosterone (DHT) and testosterone levels were assessed before and 6 to 12 months after varicocelectomy in 22 men with varicoceles. Twelve men were severely Oligozoospermie (sperm densities<10 × 106/ml), whereas 10 men had sperm densities between 11 and 30 × 106/ml. Each man had excessive gonadotropin responses to GnRH and lower than normal seminal plasma DHT levels preoperatively. Eight of the 12 severely Oligozoospermie men and 6 of the other 10 men had postoperative improvements in sperm density. These men (responders) had normalization of gonadotropin response and seminal plasma DHT levels. The nonresponders had identical hormonal parameters before and after surgery.
These results indicate that the pantesticular defect in hormonal synthesis and spermatogenesis, seen in some men with varicoceles, can be reversible.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>3922807</pmid><doi>10.1016/S0015-0282(16)48620-6</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Fertility and sterility, 1985-06, Vol.43 (6), p.905-910 |
| issn | 0015-0282 1556-5653 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present); Alma/SFX Local Collection |
| subjects | Adult Biological and medical sciences Birth control Dihydrotestosterone - blood Estradiol - blood Follicle Stimulating Hormone - blood Gonadotropin-Releasing Hormone Gynecology. Andrology. Obstetrics Humans Luteinizing Hormone - blood Male Medical sciences Oligospermia - blood Oligospermia - etiology Semen - analysis Sperm Count Sterility. Assisted procreation Testosterone - blood Varicocele - blood Varicocele - complications Varicocele - surgery |
| title | Hormonal parameters of men with varicoceles before and after varicocelectomy |
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