Increased lipid peroxide levels and myeloperoxidase activity in the vitreous of patients suffering from proliferative diabetic retinopathy
Lipid peroxide (LPO) levels, as determined by high-performance liquid chromatography (HPLC) and by the thiobarbituric acid (TBA) method, and myeloperoxidase (MPO) activity in vitreous of patients vitrectomized because of proliferative diabetic retinopathy were compared with LPO levels and MPO activi...
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| Veröffentlicht in: | Graefe's archive for clinical and experimental ophthalmology 1993-11, Vol.231 (11), p.647-650 |
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| container_title | Graefe's archive for clinical and experimental ophthalmology |
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| creator | AUGUSTIN, A. J BREIPOHL, W BÖKER, T LUTZ, J SPITZNAS, M |
| description | Lipid peroxide (LPO) levels, as determined by high-performance liquid chromatography (HPLC) and by the thiobarbituric acid (TBA) method, and myeloperoxidase (MPO) activity in vitreous of patients vitrectomized because of proliferative diabetic retinopathy were compared with LPO levels and MPO activity in vitreous of patients with no vitreoretinal proliferation. Both LPO levels and MPO activity were significantly elevated in the vitreous of patients with fibrovascular vitreoretinal proliferations secondary to diabetes. The TBA method produced higher values for LPO levels than did the HPLC method. The correlation between the two methods was 0.94. Our results suggest that both oxygen-free radicals and inflammation-related reactions can participate in the pathogenesis of diabetic retinopathy. |
| doi_str_mv | 10.1007/bf00921959 |
| format | Article |
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Both LPO levels and MPO activity were significantly elevated in the vitreous of patients with fibrovascular vitreoretinal proliferations secondary to diabetes. The TBA method produced higher values for LPO levels than did the HPLC method. The correlation between the two methods was 0.94. Our results suggest that both oxygen-free radicals and inflammation-related reactions can participate in the pathogenesis of diabetic retinopathy.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>8258399</pmid><doi>10.1007/bf00921959</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0721-832X |
| ispartof | Graefe's archive for clinical and experimental ophthalmology, 1993-11, Vol.231 (11), p.647-650 |
| issn | 0721-832X 1435-702X |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Associated diseases and complications Biological and medical sciences Chromatography, High Pressure Liquid Diabetes. Impaired glucose tolerance Diabetic Retinopathy - complications Diabetic Retinopathy - metabolism Endocrine pancreas. Apud cells (diseases) Endocrinopathies Eye Diseases - etiology Eye Diseases - metabolism Humans Lipid Peroxides - metabolism Medical sciences Peroxidase - metabolism Retinal Diseases - etiology Retinal Diseases - metabolism Thiobarbituric Acid Reactive Substances - metabolism Vitreous Body - metabolism |
| title | Increased lipid peroxide levels and myeloperoxidase activity in the vitreous of patients suffering from proliferative diabetic retinopathy |
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