Insulin excess counteracts the effects of HDL on intracellular sterol accumulation in cultured human skin fibroblasts

Both Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetic individuals are at increased risk of developing ischaemic heart disease. Insulin excess, present in both diabetic groups, may play an important pathophysiologic role in accelerating the atherogenic process. In this study, cu...

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Veröffentlicht in:	Diabetologia 1993-10, Vol.36 (10), p.942-947
Hauptverfasser:	BRAZG, R. L, BIERMAN, E. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Membrane - drug effects Cell Membrane - metabolism Cells, Cultured Cholesterol - metabolism Cholesterol Esters - metabolism Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fibroblasts - drug effects Fibroblasts - metabolism Humans Insulin - pharmacology Lipoproteins, HDL - blood Lipoproteins, HDL - isolation & purification Lipoproteins, HDL - pharmacology Male Medical sciences Oleic Acid Oleic Acids - metabolism Skin - metabolism Sterols - metabolism
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