Effects of manganese on 45Ca mobilization and contractile responses in rabbit aortic smooth muscle
1. 1. In rabbit aortic smooth muscle, 1.5 mM Mn 2+ inhibits contractile responses to norepinephrine more than those to high K +. Other associated effects include decreases in the La 3+-resistant high affinity Ca 2+ fraction, the high affinity Ca 2+ uptake component in the Scatchard-coordinate plot,...
Gespeichert in:
| Veröffentlicht in: | General pharmacology 1985, Vol.16 (2), p.97-102 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 102 |
|---|---|
| container_issue | 2 |
| container_start_page | 97 |
| container_title | General pharmacology |
| container_volume | 16 |
| creator | Weiss, George B. Kutsky, Phyllis |
| description | 1.
1. In rabbit aortic smooth muscle, 1.5 mM Mn
2+ inhibits contractile responses to norepinephrine more than those to high K
+. Other associated effects include decreases in the La
3+-resistant high affinity Ca
2+ fraction, the high affinity Ca
2+ uptake component in the Scatchard-coordinate plot, and high affinity Ca
2+ uptake and binding in canine aortic microsomes.
2.
2. Higher (15 mM) concentrations of Mn
2+ are less selective.
3.
3. Thus, those Ca
2+ mobilization components and contractile responses associated with high affinity bound Ca
2+ are more sensitive to inhibition by Mn
2+. |
| doi_str_mv | 10.1016/0306-3623(85)90043-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76110134</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0306362385900436</els_id><sourcerecordid>76110134</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2046-ee2d5c93c226831b984fcb5becf4721d8c27bff8a0a570b20a0ae26622ab23a13</originalsourceid><addsrcrecordid>eNp9kE1LAzEQhoMotVb_gUJOoofVfOxmsxdBSv2Aghc9hyQ70cjupiZbQX-9qS0ePc0w877vMA9Cp5RcUULFNeFEFFwwfiGry4aQkhdiD02prJuCEEr30fRPcoiOUnonhLCKsQma8KYRUoopMgvnwI4JB4d7PbzqARLgMOCymmvcB-M7_61Hnyd6aLENwxi1HX0HOEJahSFBwn7AURvjR6xDHL3FqQ9hfMP9OtkOjtGB012Ck12doZe7xfP8oVg-3T_Ob5eFZaQUBQBrK9twy5iQnJpGls6ayoB1Zc1oKy2rjXNSE13VxDCSG2BCMKYN45ryGTrf5q5i-FhDGlXvk4Wuyz-FdVK1oJkbL7Ow3AptDClFcGoVfa_jl6JEbdCqDTe14aZkpX7RKpFtZ7v8temh_TPtWOb9zXYP-clPD1El62Gw0PqYEas2-P8P_AAI1IjA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76110134</pqid></control><display><type>article</type><title>Effects of manganese on 45Ca mobilization and contractile responses in rabbit aortic smooth muscle</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Weiss, George B. ; Kutsky, Phyllis</creator><creatorcontrib>Weiss, George B. ; Kutsky, Phyllis</creatorcontrib><description>1.
1. In rabbit aortic smooth muscle, 1.5 mM Mn
2+ inhibits contractile responses to norepinephrine more than those to high K
+. Other associated effects include decreases in the La
3+-resistant high affinity Ca
2+ fraction, the high affinity Ca
2+ uptake component in the Scatchard-coordinate plot, and high affinity Ca
2+ uptake and binding in canine aortic microsomes.
2.
2. Higher (15 mM) concentrations of Mn
2+ are less selective.
3.
3. Thus, those Ca
2+ mobilization components and contractile responses associated with high affinity bound Ca
2+ are more sensitive to inhibition by Mn
2+.</description><identifier>ISSN: 0306-3623</identifier><identifier>EISSN: 1879-0011</identifier><identifier>DOI: 10.1016/0306-3623(85)90043-6</identifier><identifier>PMID: 3996886</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Animals ; Binding, Competitive ; Calcium - metabolism ; Calcium Radioisotopes ; Female ; In Vitro Techniques ; Kinetics ; Lanthanum - pharmacology ; Male ; Manganese - pharmacology ; Muscle Contraction - drug effects ; Muscle, Smooth, Vascular - drug effects ; Muscle, Smooth, Vascular - metabolism ; Norepinephrine - pharmacology ; Potassium - pharmacology ; Rabbits ; Time Factors</subject><ispartof>General pharmacology, 1985, Vol.16 (2), p.97-102</ispartof><rights>1985</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2046-ee2d5c93c226831b984fcb5becf4721d8c27bff8a0a570b20a0ae26622ab23a13</citedby><cites>FETCH-LOGICAL-c2046-ee2d5c93c226831b984fcb5becf4721d8c27bff8a0a570b20a0ae26622ab23a13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3996886$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weiss, George B.</creatorcontrib><creatorcontrib>Kutsky, Phyllis</creatorcontrib><title>Effects of manganese on 45Ca mobilization and contractile responses in rabbit aortic smooth muscle</title><title>General pharmacology</title><addtitle>Gen Pharmacol</addtitle><description>1.
1. In rabbit aortic smooth muscle, 1.5 mM Mn
2+ inhibits contractile responses to norepinephrine more than those to high K
+. Other associated effects include decreases in the La
3+-resistant high affinity Ca
2+ fraction, the high affinity Ca
2+ uptake component in the Scatchard-coordinate plot, and high affinity Ca
2+ uptake and binding in canine aortic microsomes.
2.
2. Higher (15 mM) concentrations of Mn
2+ are less selective.
3.
3. Thus, those Ca
2+ mobilization components and contractile responses associated with high affinity bound Ca
2+ are more sensitive to inhibition by Mn
2+.</description><subject>Animals</subject><subject>Binding, Competitive</subject><subject>Calcium - metabolism</subject><subject>Calcium Radioisotopes</subject><subject>Female</subject><subject>In Vitro Techniques</subject><subject>Kinetics</subject><subject>Lanthanum - pharmacology</subject><subject>Male</subject><subject>Manganese - pharmacology</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle, Smooth, Vascular - drug effects</subject><subject>Muscle, Smooth, Vascular - metabolism</subject><subject>Norepinephrine - pharmacology</subject><subject>Potassium - pharmacology</subject><subject>Rabbits</subject><subject>Time Factors</subject><issn>0306-3623</issn><issn>1879-0011</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotVb_gUJOoofVfOxmsxdBSv2Aghc9hyQ70cjupiZbQX-9qS0ePc0w877vMA9Cp5RcUULFNeFEFFwwfiGry4aQkhdiD02prJuCEEr30fRPcoiOUnonhLCKsQma8KYRUoopMgvnwI4JB4d7PbzqARLgMOCymmvcB-M7_61Hnyd6aLENwxi1HX0HOEJahSFBwn7AURvjR6xDHL3FqQ9hfMP9OtkOjtGB012Ck12doZe7xfP8oVg-3T_Ob5eFZaQUBQBrK9twy5iQnJpGls6ayoB1Zc1oKy2rjXNSE13VxDCSG2BCMKYN45ryGTrf5q5i-FhDGlXvk4Wuyz-FdVK1oJkbL7Ow3AptDClFcGoVfa_jl6JEbdCqDTe14aZkpX7RKpFtZ7v8temh_TPtWOb9zXYP-clPD1El62Gw0PqYEas2-P8P_AAI1IjA</recordid><startdate>1985</startdate><enddate>1985</enddate><creator>Weiss, George B.</creator><creator>Kutsky, Phyllis</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1985</creationdate><title>Effects of manganese on 45Ca mobilization and contractile responses in rabbit aortic smooth muscle</title><author>Weiss, George B. ; Kutsky, Phyllis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2046-ee2d5c93c226831b984fcb5becf4721d8c27bff8a0a570b20a0ae26622ab23a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Binding, Competitive</topic><topic>Calcium - metabolism</topic><topic>Calcium Radioisotopes</topic><topic>Female</topic><topic>In Vitro Techniques</topic><topic>Kinetics</topic><topic>Lanthanum - pharmacology</topic><topic>Male</topic><topic>Manganese - pharmacology</topic><topic>Muscle Contraction - drug effects</topic><topic>Muscle, Smooth, Vascular - drug effects</topic><topic>Muscle, Smooth, Vascular - metabolism</topic><topic>Norepinephrine - pharmacology</topic><topic>Potassium - pharmacology</topic><topic>Rabbits</topic><topic>Time Factors</topic><toplevel>online_resources</toplevel><creatorcontrib>Weiss, George B.</creatorcontrib><creatorcontrib>Kutsky, Phyllis</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>General pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weiss, George B.</au><au>Kutsky, Phyllis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of manganese on 45Ca mobilization and contractile responses in rabbit aortic smooth muscle</atitle><jtitle>General pharmacology</jtitle><addtitle>Gen Pharmacol</addtitle><date>1985</date><risdate>1985</risdate><volume>16</volume><issue>2</issue><spage>97</spage><epage>102</epage><pages>97-102</pages><issn>0306-3623</issn><eissn>1879-0011</eissn><abstract>1.
1. In rabbit aortic smooth muscle, 1.5 mM Mn
2+ inhibits contractile responses to norepinephrine more than those to high K
+. Other associated effects include decreases in the La
3+-resistant high affinity Ca
2+ fraction, the high affinity Ca
2+ uptake component in the Scatchard-coordinate plot, and high affinity Ca
2+ uptake and binding in canine aortic microsomes.
2.
2. Higher (15 mM) concentrations of Mn
2+ are less selective.
3.
3. Thus, those Ca
2+ mobilization components and contractile responses associated with high affinity bound Ca
2+ are more sensitive to inhibition by Mn
2+.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>3996886</pmid><doi>10.1016/0306-3623(85)90043-6</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0306-3623 |
| ispartof | General pharmacology, 1985, Vol.16 (2), p.97-102 |
| issn | 0306-3623 1879-0011 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76110134 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Binding, Competitive Calcium - metabolism Calcium Radioisotopes Female In Vitro Techniques Kinetics Lanthanum - pharmacology Male Manganese - pharmacology Muscle Contraction - drug effects Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Norepinephrine - pharmacology Potassium - pharmacology Rabbits Time Factors |
| title | Effects of manganese on 45Ca mobilization and contractile responses in rabbit aortic smooth muscle |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T19%3A52%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20manganese%20on%2045Ca%20mobilization%20and%20contractile%20responses%20in%20rabbit%20aortic%20smooth%20muscle&rft.jtitle=General%20pharmacology&rft.au=Weiss,%20George%20B.&rft.date=1985&rft.volume=16&rft.issue=2&rft.spage=97&rft.epage=102&rft.pages=97-102&rft.issn=0306-3623&rft.eissn=1879-0011&rft_id=info:doi/10.1016/0306-3623(85)90043-6&rft_dat=%3Cproquest_cross%3E76110134%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=76110134&rft_id=info:pmid/3996886&rft_els_id=0306362385900436&rfr_iscdi=true |