ARACHnase : an evaluation of a positive control for platelet neutralization procedure testing with seven commercial activated partial thromboplastin time reagents
ARACHnase (Hemostasis Diagnostics International Co., Denver, CO) is a normal plasma that contains a venom extract from the brown recluse spider, Loxosceles reclusa, which mimics the presence of a lupus anticoagulant (LA). Seven activated partial thromboplastin time (APTT) reagents were used for plat...
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| Veröffentlicht in: | American journal of clinical pathology 1993-11, Vol.100 (5), p.576-578 |
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| container_end_page | 578 |
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| container_issue | 5 |
| container_start_page | 576 |
| container_title | American journal of clinical pathology |
| container_volume | 100 |
| creator | MCGLASSON, D. L BABCOCK, J. L BERG, L TRIPLETT, D. A |
| description | ARACHnase (Hemostasis Diagnostics International Co., Denver, CO) is a normal plasma that contains a venom extract from the brown recluse spider, Loxosceles reclusa, which mimics the presence of a lupus anticoagulant (LA). Seven activated partial thromboplastin time (APTT) reagents were used for platelet neutralization procedure (PNP) testing with ARACHnase: Automated APTT (Organon-Teknika, Durham, NC); Thrombofax and Thrombosil (Ortho, Raritan, NJ); Actin and Actin FSL (Dade, Aguado, PR); and Thromboscreen-Kontact and Thromboscreen-APTT LS (Pacific-Hemostasis, Ventura, CA). ARACHnase consistently displayed a positive PNP result of greater than 5 seconds correction of the initial baseline APTT. Thus, ARACHnase may provide a positive control for LA testing, regardless of the choice of APTT reagent and activator/phospholipid combination. |
| doi_str_mv | 10.1093/ajcp/100.5.576 |
| format | Article |
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L ; BABCOCK, J. L ; BERG, L ; TRIPLETT, D. A</creator><creatorcontrib>MCGLASSON, D. L ; BABCOCK, J. L ; BERG, L ; TRIPLETT, D. A</creatorcontrib><description>ARACHnase (Hemostasis Diagnostics International Co., Denver, CO) is a normal plasma that contains a venom extract from the brown recluse spider, Loxosceles reclusa, which mimics the presence of a lupus anticoagulant (LA). Seven activated partial thromboplastin time (APTT) reagents were used for platelet neutralization procedure (PNP) testing with ARACHnase: Automated APTT (Organon-Teknika, Durham, NC); Thrombofax and Thrombosil (Ortho, Raritan, NJ); Actin and Actin FSL (Dade, Aguado, PR); and Thromboscreen-Kontact and Thromboscreen-APTT LS (Pacific-Hemostasis, Ventura, CA). ARACHnase consistently displayed a positive PNP result of greater than 5 seconds correction of the initial baseline APTT. Thus, ARACHnase may provide a positive control for LA testing, regardless of the choice of APTT reagent and activator/phospholipid combination.</description><identifier>ISSN: 0002-9173</identifier><identifier>EISSN: 1943-7722</identifier><identifier>DOI: 10.1093/ajcp/100.5.576</identifier><identifier>PMID: 8249897</identifier><identifier>CODEN: AJCPAI</identifier><language>eng</language><publisher>Chicago, IL: American Society of Clinical Pathologists</publisher><subject>Adult ; Biological and medical sciences ; Blood coagulation ; Female ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Lupus Coagulation Inhibitor - drug effects ; Male ; Medical sciences ; Middle Aged ; Partial Thromboplastin Time ; Plasma - drug effects ; Platelet Aggregation Inhibitors - pharmacology ; Reagent Kits, Diagnostic ; Sensitivity and Specificity ; Spider Venoms</subject><ispartof>American journal of clinical pathology, 1993-11, Vol.100 (5), p.576-578</ispartof><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c234t-d01063bb0de7b74cf8f073e288b09456614f1bb98fc9b3190a77cfd0cd50fae33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4121269$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8249897$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MCGLASSON, D. L</creatorcontrib><creatorcontrib>BABCOCK, J. L</creatorcontrib><creatorcontrib>BERG, L</creatorcontrib><creatorcontrib>TRIPLETT, D. A</creatorcontrib><title>ARACHnase : an evaluation of a positive control for platelet neutralization procedure testing with seven commercial activated partial thromboplastin time reagents</title><title>American journal of clinical pathology</title><addtitle>Am J Clin Pathol</addtitle><description>ARACHnase (Hemostasis Diagnostics International Co., Denver, CO) is a normal plasma that contains a venom extract from the brown recluse spider, Loxosceles reclusa, which mimics the presence of a lupus anticoagulant (LA). Seven activated partial thromboplastin time (APTT) reagents were used for platelet neutralization procedure (PNP) testing with ARACHnase: Automated APTT (Organon-Teknika, Durham, NC); Thrombofax and Thrombosil (Ortho, Raritan, NJ); Actin and Actin FSL (Dade, Aguado, PR); and Thromboscreen-Kontact and Thromboscreen-APTT LS (Pacific-Hemostasis, Ventura, CA). ARACHnase consistently displayed a positive PNP result of greater than 5 seconds correction of the initial baseline APTT. Thus, ARACHnase may provide a positive control for LA testing, regardless of the choice of APTT reagent and activator/phospholipid combination.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood coagulation</subject><subject>Female</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Lupus Coagulation Inhibitor - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Partial Thromboplastin Time</subject><subject>Plasma - drug effects</subject><subject>Platelet Aggregation Inhibitors - pharmacology</subject><subject>Reagent Kits, Diagnostic</subject><subject>Sensitivity and Specificity</subject><subject>Spider Venoms</subject><issn>0002-9173</issn><issn>1943-7722</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kUGLFDEQhYMo67h69SbkIN56ttLJdDrehkFdYUEQPTfpdGU3Szppk_SI_hx_qRlm2FMVVe99RfEIectgy0DxG_1olhsGsN1td7J7RjZMCd5I2bbPyQYA2kYxyV-SVzk_ArC2B3FFrvpWqF7JDfm3_74_3AadkX6kOlA8ar_q4mKg0VJNl5hdcUekJoaSoqc2Jrp4XdBjoQHXkrR3f8-OJUWD05qQFszFhXv625UHmvGIoQLmGZNx2lNtKrIiJrroVE6T8pDiPMYKPvlocTPShPoeQ8mvyQurfcY3l3pNfn7-9ONw29x9-_L1sL9rTMtFaSZg0PFxhAnlKIWxvQXJse37EZTYdR0Tlo2j6q1RI2cKtJTGTmCmHViNnF-TD2dufePXWh8YZpcNeq8DxjUPsqsHeiGqcHsWmhRzTmiHJblZpz8Dg-EUynAKpXYw7IYaSjW8u5DXccbpSX5Joe7fX_Y6G-1t0sG4_CQTrGVtp_h_I32aCA</recordid><startdate>199311</startdate><enddate>199311</enddate><creator>MCGLASSON, D. L</creator><creator>BABCOCK, J. L</creator><creator>BERG, L</creator><creator>TRIPLETT, D. A</creator><general>American Society of Clinical Pathologists</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199311</creationdate><title>ARACHnase : an evaluation of a positive control for platelet neutralization procedure testing with seven commercial activated partial thromboplastin time reagents</title><author>MCGLASSON, D. L ; BABCOCK, J. L ; BERG, L ; TRIPLETT, D. A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c234t-d01063bb0de7b74cf8f073e288b09456614f1bb98fc9b3190a77cfd0cd50fae33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood coagulation</topic><topic>Female</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Lupus Coagulation Inhibitor - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Partial Thromboplastin Time</topic><topic>Plasma - drug effects</topic><topic>Platelet Aggregation Inhibitors - pharmacology</topic><topic>Reagent Kits, Diagnostic</topic><topic>Sensitivity and Specificity</topic><topic>Spider Venoms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MCGLASSON, D. L</creatorcontrib><creatorcontrib>BABCOCK, J. L</creatorcontrib><creatorcontrib>BERG, L</creatorcontrib><creatorcontrib>TRIPLETT, D. A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MCGLASSON, D. L</au><au>BABCOCK, J. L</au><au>BERG, L</au><au>TRIPLETT, D. A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ARACHnase : an evaluation of a positive control for platelet neutralization procedure testing with seven commercial activated partial thromboplastin time reagents</atitle><jtitle>American journal of clinical pathology</jtitle><addtitle>Am J Clin Pathol</addtitle><date>1993-11</date><risdate>1993</risdate><volume>100</volume><issue>5</issue><spage>576</spage><epage>578</epage><pages>576-578</pages><issn>0002-9173</issn><eissn>1943-7722</eissn><coden>AJCPAI</coden><abstract>ARACHnase (Hemostasis Diagnostics International Co., Denver, CO) is a normal plasma that contains a venom extract from the brown recluse spider, Loxosceles reclusa, which mimics the presence of a lupus anticoagulant (LA). Seven activated partial thromboplastin time (APTT) reagents were used for platelet neutralization procedure (PNP) testing with ARACHnase: Automated APTT (Organon-Teknika, Durham, NC); Thrombofax and Thrombosil (Ortho, Raritan, NJ); Actin and Actin FSL (Dade, Aguado, PR); and Thromboscreen-Kontact and Thromboscreen-APTT LS (Pacific-Hemostasis, Ventura, CA). ARACHnase consistently displayed a positive PNP result of greater than 5 seconds correction of the initial baseline APTT. Thus, ARACHnase may provide a positive control for LA testing, regardless of the choice of APTT reagent and activator/phospholipid combination.</abstract><cop>Chicago, IL</cop><pub>American Society of Clinical Pathologists</pub><pmid>8249897</pmid><doi>10.1093/ajcp/100.5.576</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9173 |
| ispartof | American journal of clinical pathology, 1993-11, Vol.100 (5), p.576-578 |
| issn | 0002-9173 1943-7722 |
| language | eng |
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| source | MEDLINE; Oxford University Press Archive |
| subjects | Adult Biological and medical sciences Blood coagulation Female Humans Investigative techniques, diagnostic techniques (general aspects) Lupus Coagulation Inhibitor - drug effects Male Medical sciences Middle Aged Partial Thromboplastin Time Plasma - drug effects Platelet Aggregation Inhibitors - pharmacology Reagent Kits, Diagnostic Sensitivity and Specificity Spider Venoms |
| title | ARACHnase : an evaluation of a positive control for platelet neutralization procedure testing with seven commercial activated partial thromboplastin time reagents |
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