The herbicide ketoclomazone inhibits 1-deoxy-D-xylulose 5-phosphate synthase in the 2-C-methyl-D-erythritol 4-phosphate pathway and shows antibacterial activity against Haemophilus influenzae

Two distinct metabolic pathways have been elucidated for the formation of isopentenyl diphosphate and dimethylallyl diphosphate, essential metabolic precursors for isoprenoid biosynthesis: the mevalonate pathway, found ubiquitously in mammals, and the 2- C -methyl- D -erythritol 4-phosphate (MEP) pa...

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Veröffentlicht in:	Journal of antibiotics 2010-10, Vol.63 (10), p.583-588
Hauptverfasser:	Matsue, Yukiko, Mizuno, Hiroko, Tomita, Takeo, Asami, Tadao, Nishiyama, Makoto, Kuzuyama, Tomohisa
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/436 631/326/22/1290 631/326/41 Anti-Bacterial Agents - pharmacology Bacteriology Binding Sites Biomedical and Life Sciences Bioorganic Chemistry Biosynthesis Drug Delivery Systems E coli Enzyme Inhibitors - pharmacology Erythritol - analogs & derivatives Erythritol - metabolism Escherichia coli - drug effects Haemophilus influenzae - drug effects Herbicides Herbicides - pharmacology Isoxazoles - pharmacology Kinetics Life Sciences Mammals Medicinal Chemistry Microbial Sensitivity Tests Microbiology Organic Chemistry original-article Oxazolidinones - pharmacology Protein Binding Sugar Phosphates - metabolism Transferases - antagonists & inhibitors
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