An acylic polyisoprenoid derivative, geranylgeranylacetone protects against visceral adiposity and insulin resistance in high-fat-fed mice

Induction of heat shock protein (HSP)72 improves insulin resistance and obesity in diabetic animal models. Geranylgeranylacetone (GGA), known as an antiulcer drug, induces HSP72 and protects organs against several cellular stresses. This study investigated whether GGA administration would induce HSP...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 2010-11, Vol.299 (5), p.E764-E771
Hauptverfasser:	Adachi, Hironori, Kondo, Tatsuya, Ogawa, Rei, Sasaki, Kazunari, Morino-Koga, Saori, Sakakida, Michiharu, Kawashima, Junji, Motoshima, Hiroyuki, Furukawa, Noboru, Tsuruzoe, Kaku, Miyamura, Nobuhiro, Kai, Hirofumi, Araki, Eiichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiponectin - physiology Animals Area Under Curve Blood Glucose - metabolism Body Weight - physiology Diabetes Diet Diterpenes - pharmacology Eating - physiology Glucose Glucose Tolerance Test HSP72 Heat-Shock Proteins - metabolism Insulin - blood Insulin resistance Insulin Resistance - physiology Intra-Abdominal Fat - metabolism Leptin - physiology Liver Liver - physiology Male Mice Mice, Inbred C57BL Obesity Proteins Rodents Signal transduction Signal Transduction - drug effects
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