Pituitary luteinizing hormone-releasing hormone receptors in ovariectomized cows after challenge with ovarian steroids
Acute changes of bovine pituitary luteinizing hormone-releasing hormone (LHRH) receptors in response to steroid challenges have not been documented. To investigate these changes 96 ovariectomized (OVX) cows were randomly allotted to one of the following treatments: 1) 1 mg estriol (E3); 2) 1 mg 17 b...
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| Veröffentlicht in: | Biology of reproduction 1985-04, Vol.32 (3), p.574-583 |
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| creator | Schoenemann, H.M Humphrey, W.D Crowder, M.E Nett, T.M Reeves, J.J |
| description | Acute changes of bovine pituitary luteinizing hormone-releasing hormone (LHRH) receptors in response to steroid challenges
have not been documented. To investigate these changes 96 ovariectomized (OVX) cows were randomly allotted to one of the following
treatments: 1) 1 mg estriol (E3); 2) 1 mg 17 beta-estradiol (E2); or 3) 25 mg progesterone (P) twice daily for 7 days before
1 mg E2 and continuing to the end of the experiment. Serum was collected at hourly intervals from 4 animals in each group
for 28 h following estrogen treatment. Four animals from each treatment were killed at 4-h intervals from 0 to 28 h after
estrogen injection to recover pituitaries and hypothalami. Treatment with E3 or E2 decreased serum luteinizing hormone (LH)
within 3 h and was followed by surges of LH that were temporally and quantitatively similar (P greater than 0.05). Progesterone
did not block the decline in serum LH, but did prevent (P less than 0.05) the E2-induced surge of LH. Serum follicle-stimulating
hormone (FSH) was unaffected (P less than 0.05) by treatment. Pituitary concentrations of LH and FSH were maximal (P less
than 0.001) at 16 h for E3 and 20 h for E2, whereas P prevented (P greater than 0.05) the pituitary gonadotropin increase.
Concentrations of LHRH in the hypothalamus were similar (P greater than 0.05) among treatments. Pituitary concentrations of
receptors for LHRH were maximal (P less than 0.005) 12 h after estrogen injection (approximately 8 h before the LH surge),
even in the presence of P. This study demonstrated that in the OVX cow: 1) E2 and E3 increased the concentration of receptors
for LHRH and this increase occurred before the surge of LH; and 2) P did not block the E2-induced increase in pituitary receptors
for LHRH but did prevent the surge of LH. |
| doi_str_mv | 10.1095/biolreprod32.3.574 |
| format | Article |
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have not been documented. To investigate these changes 96 ovariectomized (OVX) cows were randomly allotted to one of the following
treatments: 1) 1 mg estriol (E3); 2) 1 mg 17 beta-estradiol (E2); or 3) 25 mg progesterone (P) twice daily for 7 days before
1 mg E2 and continuing to the end of the experiment. Serum was collected at hourly intervals from 4 animals in each group
for 28 h following estrogen treatment. Four animals from each treatment were killed at 4-h intervals from 0 to 28 h after
estrogen injection to recover pituitaries and hypothalami. Treatment with E3 or E2 decreased serum luteinizing hormone (LH)
within 3 h and was followed by surges of LH that were temporally and quantitatively similar (P greater than 0.05). Progesterone
did not block the decline in serum LH, but did prevent (P less than 0.05) the E2-induced surge of LH. Serum follicle-stimulating
hormone (FSH) was unaffected (P less than 0.05) by treatment. Pituitary concentrations of LH and FSH were maximal (P less
than 0.001) at 16 h for E3 and 20 h for E2, whereas P prevented (P greater than 0.05) the pituitary gonadotropin increase.
Concentrations of LHRH in the hypothalamus were similar (P greater than 0.05) among treatments. Pituitary concentrations of
receptors for LHRH were maximal (P less than 0.005) 12 h after estrogen injection (approximately 8 h before the LH surge),
even in the presence of P. This study demonstrated that in the OVX cow: 1) E2 and E3 increased the concentration of receptors
for LHRH and this increase occurred before the surge of LH; and 2) P did not block the E2-induced increase in pituitary receptors
for LHRH but did prevent the surge of LH.</description><identifier>ISSN: 0006-3363</identifier><identifier>EISSN: 1529-7268</identifier><identifier>DOI: 10.1095/biolreprod32.3.574</identifier><identifier>PMID: 2986740</identifier><identifier>CODEN: BIREBV</identifier><language>eng</language><publisher>Madison, WI: Society for the Study of Reproduction</publisher><subject>Animals ; Biological and medical sciences ; Castration ; Cattle ; CEBU ; COWS ; CROSSES ; ESTEROIDES ; Estradiol - pharmacology ; Estriol - pharmacology ; Female ; Follicle Stimulating Hormone - blood ; Follicle Stimulating Hormone - metabolism ; Fundamental and applied biological sciences. Psychology ; GLANDULA PITUITARIA ; HORMONAS LIBERADORAS ; Hormone metabolism and regulation ; HYPOPHYSE ; Hypothalamus - metabolism ; Luteinizing Hormone - blood ; Luteinizing Hormone - metabolism ; Mammalian female genital system ; OVAIRE ; OVARIECTOMIZED FEMALES ; OVARIES ; OVARIOS ; PITUITARY GLAND ; Pituitary Gland - metabolism ; Progesterone - pharmacology ; RECEPTORS ; Receptors, Cell Surface - metabolism ; Receptors, LHRH ; RELEASING HORMONE ; RELEASING HORMONES ; STEROIDE ; STEROIDS ; Tissue Distribution ; VACA ; VACHE ; Vertebrates: reproduction ; ZEBU ; ZEBU CATTLE</subject><ispartof>Biology of reproduction, 1985-04, Vol.32 (3), p.574-583</ispartof><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9274125$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2986740$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schoenemann, H.M</creatorcontrib><creatorcontrib>Humphrey, W.D</creatorcontrib><creatorcontrib>Crowder, M.E</creatorcontrib><creatorcontrib>Nett, T.M</creatorcontrib><creatorcontrib>Reeves, J.J</creatorcontrib><title>Pituitary luteinizing hormone-releasing hormone receptors in ovariectomized cows after challenge with ovarian steroids</title><title>Biology of reproduction</title><addtitle>Biol Reprod</addtitle><description>Acute changes of bovine pituitary luteinizing hormone-releasing hormone (LHRH) receptors in response to steroid challenges
have not been documented. To investigate these changes 96 ovariectomized (OVX) cows were randomly allotted to one of the following
treatments: 1) 1 mg estriol (E3); 2) 1 mg 17 beta-estradiol (E2); or 3) 25 mg progesterone (P) twice daily for 7 days before
1 mg E2 and continuing to the end of the experiment. Serum was collected at hourly intervals from 4 animals in each group
for 28 h following estrogen treatment. Four animals from each treatment were killed at 4-h intervals from 0 to 28 h after
estrogen injection to recover pituitaries and hypothalami. Treatment with E3 or E2 decreased serum luteinizing hormone (LH)
within 3 h and was followed by surges of LH that were temporally and quantitatively similar (P greater than 0.05). Progesterone
did not block the decline in serum LH, but did prevent (P less than 0.05) the E2-induced surge of LH. Serum follicle-stimulating
hormone (FSH) was unaffected (P less than 0.05) by treatment. Pituitary concentrations of LH and FSH were maximal (P less
than 0.001) at 16 h for E3 and 20 h for E2, whereas P prevented (P greater than 0.05) the pituitary gonadotropin increase.
Concentrations of LHRH in the hypothalamus were similar (P greater than 0.05) among treatments. Pituitary concentrations of
receptors for LHRH were maximal (P less than 0.005) 12 h after estrogen injection (approximately 8 h before the LH surge),
even in the presence of P. This study demonstrated that in the OVX cow: 1) E2 and E3 increased the concentration of receptors
for LHRH and this increase occurred before the surge of LH; and 2) P did not block the E2-induced increase in pituitary receptors
for LHRH but did prevent the surge of LH.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Castration</subject><subject>Cattle</subject><subject>CEBU</subject><subject>COWS</subject><subject>CROSSES</subject><subject>ESTEROIDES</subject><subject>Estradiol - pharmacology</subject><subject>Estriol - pharmacology</subject><subject>Female</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Follicle Stimulating Hormone - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GLANDULA PITUITARIA</subject><subject>HORMONAS LIBERADORAS</subject><subject>Hormone metabolism and regulation</subject><subject>HYPOPHYSE</subject><subject>Hypothalamus - metabolism</subject><subject>Luteinizing Hormone - blood</subject><subject>Luteinizing Hormone - metabolism</subject><subject>Mammalian female genital system</subject><subject>OVAIRE</subject><subject>OVARIECTOMIZED FEMALES</subject><subject>OVARIES</subject><subject>OVARIOS</subject><subject>PITUITARY GLAND</subject><subject>Pituitary Gland - metabolism</subject><subject>Progesterone - pharmacology</subject><subject>RECEPTORS</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>Receptors, LHRH</subject><subject>RELEASING HORMONE</subject><subject>RELEASING HORMONES</subject><subject>STEROIDE</subject><subject>STEROIDS</subject><subject>Tissue Distribution</subject><subject>VACA</subject><subject>VACHE</subject><subject>Vertebrates: reproduction</subject><subject>ZEBU</subject><subject>ZEBU CATTLE</subject><issn>0006-3363</issn><issn>1529-7268</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUGL1TAURoMo45vRPzAgZKHu-kxym6RdyjA6woCCzrqkye1rpG2eSTrF-fUG3kPcuQrc73AWJ4Rcc7bnrJUfeh-miMcYHIg97KWun5Edl6KttFDNc7JjjKkKQMFLcpnST8Z4DQIuyIVoG6VrtiOP33xefTbxN53WjH7xT3450DHEOSxYRZzQpH8uNKLFYw4xUb_Q8GiiR5vD7J_QURu2RM2QMVI7mmnC5YB083k8gWahqWzBu_SKvBjMlPD1-b0iD59uf9zcVfdfP3-5-XhfDcBlrsDJvm2E7mXD2oaBE4PpHTMOEfpeNw2H1oAEq6WwPa-5HVStGz4458AyDVfk_clbIv1aMeVu9sniNJkFw5o6rTgDqf4PFrfipVoB35zBtZ_Rdcfo51KvOxct-9vzbpI10xDNYn36i7VC11zIgr07YaM_jJuP2KW5FCtS6LZtA9FBV_6zcNcnbjChM4dYVA_fG8W5ghb-AACjn4Y</recordid><startdate>198504</startdate><enddate>198504</enddate><creator>Schoenemann, H.M</creator><creator>Humphrey, W.D</creator><creator>Crowder, M.E</creator><creator>Nett, T.M</creator><creator>Reeves, J.J</creator><general>Society for the Study of Reproduction</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7SQ</scope><scope>7X8</scope></search><sort><creationdate>198504</creationdate><title>Pituitary luteinizing hormone-releasing hormone receptors in ovariectomized cows after challenge with ovarian steroids</title><author>Schoenemann, H.M ; Humphrey, W.D ; Crowder, M.E ; Nett, T.M ; Reeves, J.J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f315t-3d5b9827b5809803d2fabd0adee3bb788139a353c752cb141cf64781fddd3c073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Castration</topic><topic>Cattle</topic><topic>CEBU</topic><topic>COWS</topic><topic>CROSSES</topic><topic>ESTEROIDES</topic><topic>Estradiol - pharmacology</topic><topic>Estriol - pharmacology</topic><topic>Female</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Follicle Stimulating Hormone - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GLANDULA PITUITARIA</topic><topic>HORMONAS LIBERADORAS</topic><topic>Hormone metabolism and regulation</topic><topic>HYPOPHYSE</topic><topic>Hypothalamus - metabolism</topic><topic>Luteinizing Hormone - blood</topic><topic>Luteinizing Hormone - metabolism</topic><topic>Mammalian female genital system</topic><topic>OVAIRE</topic><topic>OVARIECTOMIZED FEMALES</topic><topic>OVARIES</topic><topic>OVARIOS</topic><topic>PITUITARY GLAND</topic><topic>Pituitary Gland - metabolism</topic><topic>Progesterone - pharmacology</topic><topic>RECEPTORS</topic><topic>Receptors, Cell Surface - metabolism</topic><topic>Receptors, LHRH</topic><topic>RELEASING HORMONE</topic><topic>RELEASING HORMONES</topic><topic>STEROIDE</topic><topic>STEROIDS</topic><topic>Tissue Distribution</topic><topic>VACA</topic><topic>VACHE</topic><topic>Vertebrates: reproduction</topic><topic>ZEBU</topic><topic>ZEBU CATTLE</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schoenemann, H.M</creatorcontrib><creatorcontrib>Humphrey, W.D</creatorcontrib><creatorcontrib>Crowder, M.E</creatorcontrib><creatorcontrib>Nett, T.M</creatorcontrib><creatorcontrib>Reeves, J.J</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Endocrinology Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biology of reproduction</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schoenemann, H.M</au><au>Humphrey, W.D</au><au>Crowder, M.E</au><au>Nett, T.M</au><au>Reeves, J.J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pituitary luteinizing hormone-releasing hormone receptors in ovariectomized cows after challenge with ovarian steroids</atitle><jtitle>Biology of reproduction</jtitle><addtitle>Biol Reprod</addtitle><date>1985-04</date><risdate>1985</risdate><volume>32</volume><issue>3</issue><spage>574</spage><epage>583</epage><pages>574-583</pages><issn>0006-3363</issn><eissn>1529-7268</eissn><coden>BIREBV</coden><abstract>Acute changes of bovine pituitary luteinizing hormone-releasing hormone (LHRH) receptors in response to steroid challenges
have not been documented. To investigate these changes 96 ovariectomized (OVX) cows were randomly allotted to one of the following
treatments: 1) 1 mg estriol (E3); 2) 1 mg 17 beta-estradiol (E2); or 3) 25 mg progesterone (P) twice daily for 7 days before
1 mg E2 and continuing to the end of the experiment. Serum was collected at hourly intervals from 4 animals in each group
for 28 h following estrogen treatment. Four animals from each treatment were killed at 4-h intervals from 0 to 28 h after
estrogen injection to recover pituitaries and hypothalami. Treatment with E3 or E2 decreased serum luteinizing hormone (LH)
within 3 h and was followed by surges of LH that were temporally and quantitatively similar (P greater than 0.05). Progesterone
did not block the decline in serum LH, but did prevent (P less than 0.05) the E2-induced surge of LH. Serum follicle-stimulating
hormone (FSH) was unaffected (P less than 0.05) by treatment. Pituitary concentrations of LH and FSH were maximal (P less
than 0.001) at 16 h for E3 and 20 h for E2, whereas P prevented (P greater than 0.05) the pituitary gonadotropin increase.
Concentrations of LHRH in the hypothalamus were similar (P greater than 0.05) among treatments. Pituitary concentrations of
receptors for LHRH were maximal (P less than 0.005) 12 h after estrogen injection (approximately 8 h before the LH surge),
even in the presence of P. This study demonstrated that in the OVX cow: 1) E2 and E3 increased the concentration of receptors
for LHRH and this increase occurred before the surge of LH; and 2) P did not block the E2-induced increase in pituitary receptors
for LHRH but did prevent the surge of LH.</abstract><cop>Madison, WI</cop><pub>Society for the Study of Reproduction</pub><pmid>2986740</pmid><doi>10.1095/biolreprod32.3.574</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Biology of reproduction, 1985-04, Vol.32 (3), p.574-583 |
| issn | 0006-3363 1529-7268 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76103567 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Biological and medical sciences Castration Cattle CEBU COWS CROSSES ESTEROIDES Estradiol - pharmacology Estriol - pharmacology Female Follicle Stimulating Hormone - blood Follicle Stimulating Hormone - metabolism Fundamental and applied biological sciences. Psychology GLANDULA PITUITARIA HORMONAS LIBERADORAS Hormone metabolism and regulation HYPOPHYSE Hypothalamus - metabolism Luteinizing Hormone - blood Luteinizing Hormone - metabolism Mammalian female genital system OVAIRE OVARIECTOMIZED FEMALES OVARIES OVARIOS PITUITARY GLAND Pituitary Gland - metabolism Progesterone - pharmacology RECEPTORS Receptors, Cell Surface - metabolism Receptors, LHRH RELEASING HORMONE RELEASING HORMONES STEROIDE STEROIDS Tissue Distribution VACA VACHE Vertebrates: reproduction ZEBU ZEBU CATTLE |
| title | Pituitary luteinizing hormone-releasing hormone receptors in ovariectomized cows after challenge with ovarian steroids |
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