Mechanism of action and pure antiandrogenic properties of flutamide

Although treatment of intact adult male rats with the pure antiandrogen flutamide or a luteinizing hormone‐releasing hormone (LHRH) agonist alone leads to partial inhibition of ventral prostate weight, maximal inhibition is achieved by combination of the two drugs. Potentializing effects of the two...

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Veröffentlicht in:	Cancer 1993-12, Vol.72 (S12), p.3816-3827
1. Verfasser:	Labrie, F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen Antagonists - pharmacology Androgen-Binding Protein - genetics Animals antiandrogen Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - pharmacology Biological and medical sciences Chemotherapy cyproterone acetate Dihydrotestosterone - analysis flutamide Flutamide - administration & dosage Flutamide - pharmacology Gonadotropin-Releasing Hormone - administration & dosage Gonadotropin-Releasing Hormone - analogs & derivatives Gonadotropin-Releasing Hormone - pharmacology Humans hydroxy‐flutamide Luteinizing Hormone - blood Male Medical sciences medroxyprogesterone acetate megestrol acetate Orchiectomy Ornithine Decarboxylase - metabolism Pharmacology. Drug treatments Phosphatidylethanolamine Binding Protein Prostate - drug effects Prostate - enzymology Prostatein prostatic binding protein Prostatic Neoplasms - drug therapy Prostatic Neoplasms - pathology RNA, Messenger - analysis Secretoglobins Shionogi spironolactones Tumor Cells, Cultured - drug effects Uteroglobin
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