Reservoir characteristics of Mainz pouch studied in animal model: Osmolality of filling solution and effect of oxybutynin
In a canine model of the Mainz pouch, intracavitary pressure and compliance were measured during instillation of isosmotic and hyperosmotic (900 mmol/kg water) solutions of saline. Wall properties of small- and large-bowel segments of the pouch were assessed individually by sonomicrometry. Intralumi...
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| Veröffentlicht in: | Urology (Ridgewood, N.J.) N.J.), 1993-12, Vol.42 (6), p.741-746 |
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| container_title | Urology (Ridgewood, N.J.) |
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| creator | Hohenfellner, M. Burger, R. Schad, H. Heimisch, W. Riedmiller, H. Lampel, A. Thüroff, J.W. Hohenfellner, R. |
| description | In a canine model of the Mainz pouch, intracavitary pressure and compliance were measured during instillation of isosmotic and hyperosmotic (900 mmol/kg water) solutions of saline. Wall properties of small- and large-bowel segments of the pouch were assessed individually by sonomicrometry. Intraluminal pressures increased more steeply during filling with hyperosmotic solution, resulting in reduced distensibility of small- and large-bowel segments. Additionally, instillation of the hyperosmotic solution resulted in increased amplitudes and frequency of intracavitary pressure waves. The results indicate that this was the result of a combination of intensified bowel contractions and an increased mural tension. Topical application of oxybutynin abolished these effects. These findings are reviewed in light of the nocturnal increase in urine osmolality, its correlation with nocturnal incontinence in patients with enterocystoplasty, and possible treatment choices. |
| doi_str_mv | 10.1016/0090-4295(93)90551-K |
| format | Article |
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Wall properties of small- and large-bowel segments of the pouch were assessed individually by sonomicrometry. Intraluminal pressures increased more steeply during filling with hyperosmotic solution, resulting in reduced distensibility of small- and large-bowel segments. Additionally, instillation of the hyperosmotic solution resulted in increased amplitudes and frequency of intracavitary pressure waves. The results indicate that this was the result of a combination of intensified bowel contractions and an increased mural tension. Topical application of oxybutynin abolished these effects. These findings are reviewed in light of the nocturnal increase in urine osmolality, its correlation with nocturnal incontinence in patients with enterocystoplasty, and possible treatment choices.</description><identifier>ISSN: 0090-4295</identifier><identifier>EISSN: 1527-9995</identifier><identifier>DOI: 10.1016/0090-4295(93)90551-K</identifier><identifier>PMID: 8256411</identifier><identifier>CODEN: URGYAZ</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Cecum - drug effects ; Cecum - physiology ; Cecum - surgery ; Dogs ; Ileum - drug effects ; Ileum - physiology ; Ileum - surgery ; Mandelic Acids - pharmacology ; Medical sciences ; Models, Biological ; Muscle Contraction - drug effects ; Muscle, Smooth - drug effects ; Osmolar Concentration ; Parasympatholytics - pharmacology ; Peristalsis - drug effects ; Pressure ; Saline Solution, Hypertonic - pharmacology ; Sodium Chloride - pharmacology ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the urinary system ; Urinary Reservoirs, Continent - methods</subject><ispartof>Urology (Ridgewood, N.J.), 1993-12, Vol.42 (6), p.741-746</ispartof><rights>1993</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0090-4295(93)90551-K$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3858712$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8256411$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hohenfellner, M.</creatorcontrib><creatorcontrib>Burger, R.</creatorcontrib><creatorcontrib>Schad, H.</creatorcontrib><creatorcontrib>Heimisch, W.</creatorcontrib><creatorcontrib>Riedmiller, H.</creatorcontrib><creatorcontrib>Lampel, A.</creatorcontrib><creatorcontrib>Thüroff, J.W.</creatorcontrib><creatorcontrib>Hohenfellner, R.</creatorcontrib><title>Reservoir characteristics of Mainz pouch studied in animal model: Osmolality of filling solution and effect of oxybutynin</title><title>Urology (Ridgewood, N.J.)</title><addtitle>Urology</addtitle><description>In a canine model of the Mainz pouch, intracavitary pressure and compliance were measured during instillation of isosmotic and hyperosmotic (900 mmol/kg water) solutions of saline. Wall properties of small- and large-bowel segments of the pouch were assessed individually by sonomicrometry. Intraluminal pressures increased more steeply during filling with hyperosmotic solution, resulting in reduced distensibility of small- and large-bowel segments. Additionally, instillation of the hyperosmotic solution resulted in increased amplitudes and frequency of intracavitary pressure waves. The results indicate that this was the result of a combination of intensified bowel contractions and an increased mural tension. Topical application of oxybutynin abolished these effects. These findings are reviewed in light of the nocturnal increase in urine osmolality, its correlation with nocturnal incontinence in patients with enterocystoplasty, and possible treatment choices.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cecum - drug effects</subject><subject>Cecum - physiology</subject><subject>Cecum - surgery</subject><subject>Dogs</subject><subject>Ileum - drug effects</subject><subject>Ileum - physiology</subject><subject>Ileum - surgery</subject><subject>Mandelic Acids - pharmacology</subject><subject>Medical sciences</subject><subject>Models, Biological</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle, Smooth - drug effects</subject><subject>Osmolar Concentration</subject><subject>Parasympatholytics - pharmacology</subject><subject>Peristalsis - drug effects</subject><subject>Pressure</subject><subject>Saline Solution, Hypertonic - pharmacology</subject><subject>Sodium Chloride - pharmacology</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the urinary system</subject><subject>Urinary Reservoirs, Continent - methods</subject><issn>0090-4295</issn><issn>1527-9995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kc1u1TAQhS1EVW4LbwCSFwiVRYodx0nMAglV_FRtVQnB2nLsMR3kxBfbqQhPT0KvuprF-WZG5xxCXnJ2zhlv3zGmWNXUSp4p8VYxKXl19YTsuKy7Sikln5LdI_KMnOT8izHWtm13TI77WrYN5zuyfIMM6T5iovbOJGMLJMwFbabR0xuD01-6j7O9o7nMDsFRnKiZcDSBjtFBeE9v8xiDCViWbcVjCDj9pDmGuWDcYEfBe7Blk-OfZZjLMuH0nBx5EzK8OMxT8uPzp-8XX6vr2y-XFx-vK6gVK5VvnDSyl86DEN5xb61veV0za0XnjR-M6ztQHjzvetcI1phhGBysKu9ASHFK3jzc3af4e4Zc9IjZQghmgjhn3bVbmrxZwVcHcB5GcHqfVpdp0YesVv31QTfZmuCTmSzmR0z0su94vWIfHjBYTd0jJJ0twmTBYVpD0C6i5kxvT_XWj9760Uro_xXqK_EPNIiQjA</recordid><startdate>19931201</startdate><enddate>19931201</enddate><creator>Hohenfellner, M.</creator><creator>Burger, R.</creator><creator>Schad, H.</creator><creator>Heimisch, W.</creator><creator>Riedmiller, H.</creator><creator>Lampel, A.</creator><creator>Thüroff, J.W.</creator><creator>Hohenfellner, R.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19931201</creationdate><title>Reservoir characteristics of Mainz pouch studied in animal model: Osmolality of filling solution and effect of oxybutynin</title><author>Hohenfellner, M. ; Burger, R. ; Schad, H. ; Heimisch, W. ; Riedmiller, H. ; Lampel, A. ; Thüroff, J.W. ; Hohenfellner, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e290t-f4d5a585dfe33fd1fccf61220cc37fafbad87e9fef178d4304abbbdec3717e353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cecum - drug effects</topic><topic>Cecum - physiology</topic><topic>Cecum - surgery</topic><topic>Dogs</topic><topic>Ileum - drug effects</topic><topic>Ileum - physiology</topic><topic>Ileum - surgery</topic><topic>Mandelic Acids - pharmacology</topic><topic>Medical sciences</topic><topic>Models, Biological</topic><topic>Muscle Contraction - drug effects</topic><topic>Muscle, Smooth - drug effects</topic><topic>Osmolar Concentration</topic><topic>Parasympatholytics - pharmacology</topic><topic>Peristalsis - drug effects</topic><topic>Pressure</topic><topic>Saline Solution, Hypertonic - pharmacology</topic><topic>Sodium Chloride - pharmacology</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the urinary system</topic><topic>Urinary Reservoirs, Continent - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hohenfellner, M.</creatorcontrib><creatorcontrib>Burger, R.</creatorcontrib><creatorcontrib>Schad, H.</creatorcontrib><creatorcontrib>Heimisch, W.</creatorcontrib><creatorcontrib>Riedmiller, H.</creatorcontrib><creatorcontrib>Lampel, A.</creatorcontrib><creatorcontrib>Thüroff, J.W.</creatorcontrib><creatorcontrib>Hohenfellner, R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Urology (Ridgewood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hohenfellner, M.</au><au>Burger, R.</au><au>Schad, H.</au><au>Heimisch, W.</au><au>Riedmiller, H.</au><au>Lampel, A.</au><au>Thüroff, J.W.</au><au>Hohenfellner, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reservoir characteristics of Mainz pouch studied in animal model: Osmolality of filling solution and effect of oxybutynin</atitle><jtitle>Urology (Ridgewood, N.J.)</jtitle><addtitle>Urology</addtitle><date>1993-12-01</date><risdate>1993</risdate><volume>42</volume><issue>6</issue><spage>741</spage><epage>746</epage><pages>741-746</pages><issn>0090-4295</issn><eissn>1527-9995</eissn><coden>URGYAZ</coden><abstract>In a canine model of the Mainz pouch, intracavitary pressure and compliance were measured during instillation of isosmotic and hyperosmotic (900 mmol/kg water) solutions of saline. Wall properties of small- and large-bowel segments of the pouch were assessed individually by sonomicrometry. Intraluminal pressures increased more steeply during filling with hyperosmotic solution, resulting in reduced distensibility of small- and large-bowel segments. Additionally, instillation of the hyperosmotic solution resulted in increased amplitudes and frequency of intracavitary pressure waves. The results indicate that this was the result of a combination of intensified bowel contractions and an increased mural tension. Topical application of oxybutynin abolished these effects. These findings are reviewed in light of the nocturnal increase in urine osmolality, its correlation with nocturnal incontinence in patients with enterocystoplasty, and possible treatment choices.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8256411</pmid><doi>10.1016/0090-4295(93)90551-K</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Cecum - drug effects Cecum - physiology Cecum - surgery Dogs Ileum - drug effects Ileum - physiology Ileum - surgery Mandelic Acids - pharmacology Medical sciences Models, Biological Muscle Contraction - drug effects Muscle, Smooth - drug effects Osmolar Concentration Parasympatholytics - pharmacology Peristalsis - drug effects Pressure Saline Solution, Hypertonic - pharmacology Sodium Chloride - pharmacology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the urinary system Urinary Reservoirs, Continent - methods |
| title | Reservoir characteristics of Mainz pouch studied in animal model: Osmolality of filling solution and effect of oxybutynin |
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