Copper(I)-bleomycin: structurally unique complex that mediates oxidative DNA strand scission

Copper(I)-bleomycin [Cu(I) X BLM] was characterized in detail by 13C and 1H NMR. Unequivocal chemical shift assignments for Cu(I) X BLM and Cu(I) X BLM X CO were made by two-dimensional 1H-13C correlated spectroscopy and by utilizing the observation that Cu(I) X BLM was in rapid equilibrium with Cu(...

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Veröffentlicht in:	Biochemistry (Easton) 1985-01, Vol.24 (1), p.81-92
Hauptverfasser:	Ehrenfeld, Guy M, Rodriguez, Luis O, Hecht, Sidney M, Chang, Cynthia, Basus, Vladimir J, Oppenheimer, Norman J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Bleomycin Copper Dithiothreitol DNA, Viral General aspects Kinetics Magnetic Resonance Spectroscopy - methods Medical sciences Oxidation-Reduction Pharmacology. Drug treatments Simian virus 40
Online-Zugang:	Volltext
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