Interruption of cholinergic afferent pathways to the amygdala failed to alter electrical kindling
We investigated the hypothesis that the cholinergic system is involved in the process of amygdala kindling. Electrical kindling of the amygdala was associated with an increase in the concentration of acetylcholine in the kindled amygdala and the ipsilateral hippocampus but was not associated with an...
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| Veröffentlicht in: | Experimental neurology 1985-06, Vol.88 (3), p.742-747 |
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| container_title | Experimental neurology |
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| creator | Walker, Jonathan E. Hirsch, Sharon Crawford, Isaac L. |
| description | We investigated the hypothesis that the cholinergic system is involved in the process of amygdala kindling. Electrical kindling of the amygdala was associated with an increase in the concentration of acetylcholine in the kindled amygdala and the ipsilateral hippocampus but was not associated with any alteration of choline acetyltransferase activity. Destruction of cholinergic neurons in the lateral preoptic area significantly decreased the activity of choline acetylase in the ipsilateral amygdala, but had no effect on the duration of time to kindling. We interpret these findings as indicating that the cholinergic system is affected by the kindling process, but does not seem to be crucial to the phenomenon. |
| doi_str_mv | 10.1016/0014-4886(85)90084-6 |
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Electrical kindling of the amygdala was associated with an increase in the concentration of acetylcholine in the kindled amygdala and the ipsilateral hippocampus but was not associated with any alteration of choline acetyltransferase activity. Destruction of cholinergic neurons in the lateral preoptic area significantly decreased the activity of choline acetylase in the ipsilateral amygdala, but had no effect on the duration of time to kindling. We interpret these findings as indicating that the cholinergic system is affected by the kindling process, but does not seem to be crucial to the phenomenon.</description><identifier>ISSN: 0014-4886</identifier><identifier>EISSN: 1090-2430</identifier><identifier>DOI: 10.1016/0014-4886(85)90084-6</identifier><identifier>PMID: 3996518</identifier><identifier>CODEN: EXNEAC</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Acetylcholine - metabolism ; Afferent Pathways - physiology ; Amygdala - enzymology ; Amygdala - metabolism ; Amygdala - physiology ; Animals ; Biological and medical sciences ; Choline O-Acetyltransferase - metabolism ; Electric Stimulation ; Hippocampus - metabolism ; Kindling, Neurologic ; Medical sciences ; Nervous system involvement in other diseases. 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Electrical kindling of the amygdala was associated with an increase in the concentration of acetylcholine in the kindled amygdala and the ipsilateral hippocampus but was not associated with any alteration of choline acetyltransferase activity. Destruction of cholinergic neurons in the lateral preoptic area significantly decreased the activity of choline acetylase in the ipsilateral amygdala, but had no effect on the duration of time to kindling. We interpret these findings as indicating that the cholinergic system is affected by the kindling process, but does not seem to be crucial to the phenomenon.</description><subject>Acetylcholine - metabolism</subject><subject>Afferent Pathways - physiology</subject><subject>Amygdala - enzymology</subject><subject>Amygdala - metabolism</subject><subject>Amygdala - physiology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Choline O-Acetyltransferase - metabolism</subject><subject>Electric Stimulation</subject><subject>Hippocampus - metabolism</subject><subject>Kindling, Neurologic</subject><subject>Medical sciences</subject><subject>Nervous system involvement in other diseases. Miscellaneous</subject><subject>Neurology</subject><subject>Parasympathetic Nervous System - physiology</subject><subject>Rats</subject><issn>0014-4886</issn><issn>1090-2430</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEGLEzEUgIMoa3f1HyjkIKKH0ZdJ5k3mIsji6sKCFz2HNHlpo-lMTVKl_94ZW3r0FMj73kfyMfZCwDsBAt8DCNUorfGN7t4OAFo1-IitBAzQtErCY7a6IE_ZdSk_AGBQbX_FruQwYCf0itn7sVLOh32N08inwN12SnGkvImO2xAo01j53tbtH3ssvE68bonb3XHjbbI82JjIL9c2zR5OiVzN0dnEf8bRz6bNM_Yk2FTo-fm8Yd_vPn27_dI8fP18f_vxoXFSY230mqANiA6DxNahAqkUeEUeWrUOvRegpe2Rer-mru-ppdBpqQQOAXsa5A17ffLu8_TrQKWaXSyOUrIjTYdiehQAHcIMqhPo8lRKpmD2Oe5sPhoBZilrlmxmyWZ0Z_6VNTivvTz7D-sd-cvSOeU8f3We2zL_P2Q7ulgu2NBqiXrRfDhhNLf4HSmb4iKNjnzMczvjp_j_d_wFRZ2VWw</recordid><startdate>198506</startdate><enddate>198506</enddate><creator>Walker, Jonathan E.</creator><creator>Hirsch, Sharon</creator><creator>Crawford, Isaac L.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198506</creationdate><title>Interruption of cholinergic afferent pathways to the amygdala failed to alter electrical kindling</title><author>Walker, Jonathan E. ; Hirsch, Sharon ; Crawford, Isaac L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-8be02f66c6f362c6403440d4ed024bf7d1083a76e7dbe577e2ef5834169f67e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Acetylcholine - metabolism</topic><topic>Afferent Pathways - physiology</topic><topic>Amygdala - enzymology</topic><topic>Amygdala - metabolism</topic><topic>Amygdala - physiology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Choline O-Acetyltransferase - metabolism</topic><topic>Electric Stimulation</topic><topic>Hippocampus - metabolism</topic><topic>Kindling, Neurologic</topic><topic>Medical sciences</topic><topic>Nervous system involvement in other diseases. Miscellaneous</topic><topic>Neurology</topic><topic>Parasympathetic Nervous System - physiology</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Walker, Jonathan E.</creatorcontrib><creatorcontrib>Hirsch, Sharon</creatorcontrib><creatorcontrib>Crawford, Isaac L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Walker, Jonathan E.</au><au>Hirsch, Sharon</au><au>Crawford, Isaac L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interruption of cholinergic afferent pathways to the amygdala failed to alter electrical kindling</atitle><jtitle>Experimental neurology</jtitle><addtitle>Exp Neurol</addtitle><date>1985-06</date><risdate>1985</risdate><volume>88</volume><issue>3</issue><spage>742</spage><epage>747</epage><pages>742-747</pages><issn>0014-4886</issn><eissn>1090-2430</eissn><coden>EXNEAC</coden><abstract>We investigated the hypothesis that the cholinergic system is involved in the process of amygdala kindling. Electrical kindling of the amygdala was associated with an increase in the concentration of acetylcholine in the kindled amygdala and the ipsilateral hippocampus but was not associated with any alteration of choline acetyltransferase activity. Destruction of cholinergic neurons in the lateral preoptic area significantly decreased the activity of choline acetylase in the ipsilateral amygdala, but had no effect on the duration of time to kindling. We interpret these findings as indicating that the cholinergic system is affected by the kindling process, but does not seem to be crucial to the phenomenon.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>3996518</pmid><doi>10.1016/0014-4886(85)90084-6</doi><tpages>6</tpages></addata></record> |
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| ispartof | Experimental neurology, 1985-06, Vol.88 (3), p.742-747 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Acetylcholine - metabolism Afferent Pathways - physiology Amygdala - enzymology Amygdala - metabolism Amygdala - physiology Animals Biological and medical sciences Choline O-Acetyltransferase - metabolism Electric Stimulation Hippocampus - metabolism Kindling, Neurologic Medical sciences Nervous system involvement in other diseases. Miscellaneous Neurology Parasympathetic Nervous System - physiology Rats |
| title | Interruption of cholinergic afferent pathways to the amygdala failed to alter electrical kindling |
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