Induction of nitric oxide synthase in asthma

Nitric oxide (NO) is a mediator of vasodilatation and bronchodilatation synthesised from L-arginine by the enzyme NO synthase, which is either constitutive or induced by lipopolysaccharides and/or cytokines. The presence and function of NO synthase in normal or diseased lung is not yet clear. Asthma...

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Veröffentlicht in:	The Lancet (British edition) 1993-12, Vol.342 (8886), p.1510-1513
Hauptverfasser:	Hamid, Q, Springall, DR, Polak, JM, Riveros-Moreno, V, Chanez, P, Bousquet, J, Godard, Philippe, Holgate, S, Howarth, P, Redington, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amino Acid Oxidoreductases - biosynthesis Amino Acid Oxidoreductases - immunology Amino Acid Sequence Animals Asthma Asthma - enzymology Asthma - pathology Biological and medical sciences Bronchi - drug effects Bronchi - enzymology Bronchi - pathology Cells, Cultured Chronic obstructive pulmonary disease, asthma Enzyme Induction Epithelium - drug effects Female Humans Immunohistochemistry Lung - pathology Male Medical research Medical sciences Molecular Sequence Data Nitrates Nitric oxide Nitric Oxide Synthase Pathology Pneumology Rats Rats, Wistar Tumor Necrosis Factor-alpha - pharmacology
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