New Approaches for Determining the Site of Salivary Fluid Secretory Disorders
Considerable progress has been made in understanding the events which underlie salivary fluid secretion. We have utilized novel approaches to evaluate the functional status of three distinct sites in the secretory cascade. First, salivary sympathetic nerve function studies used isotopic dopamine to...
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| Veröffentlicht in: | Advances in dental research 1993-08, Vol.7 (2), p.220-224 |
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| container_title | Advances in dental research |
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| creator | Baum, B.J. Hiramatsu, Y. Kohn, W.G. Valdez, I.H. |
| description | Considerable progress has been made in understanding the events which underlie salivary fluid secretion. We have utilized novel approaches to evaluate the functional status of three distinct sites in the secretory cascade. First, salivary sympathetic nerve function studies used isotopic dopamine to measure catecholamine uptake and metabolism in vivo. Second, salivary muscarinic-cholinergic receptors were characterized in vivo by use of stereo-specific ligands and pharmacokinetic analyses. Finally, microfluorometric methods were used to study intracellular Ca2+ signaling in dispersed cells prepared from biopsied tissue. We conclude that it is possible to determine the functional status of key steps in salivary fluid generation with isotopic and fluorometric imaging techniques. |
| doi_str_mv | 10.1177/08959374930070021501 |
| format | Article |
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We conclude that it is possible to determine the functional status of key steps in salivary fluid generation with isotopic and fluorometric imaging techniques.</description><subject>Animals</subject><subject>Calcium - metabolism</subject><subject>Cytophotometry</subject><subject>Dentistry</subject><subject>Dopamine</subject><subject>Kinetics</subject><subject>Norepinephrine - biosynthesis</subject><subject>Parotid Gland - metabolism</subject><subject>Parotid Gland - secretion</subject><subject>Quinuclidinyl Benzilate - analogs & derivatives</subject><subject>Rats</subject><subject>Receptors, Muscarinic - metabolism</subject><subject>Saliva - secretion</subject><subject>Salivary Gland Diseases - physiopathology</subject><subject>Sympathetic Nervous System - physiology</subject><issn>0895-9374</issn><issn>1544-0737</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtPwzAQhC0EKqXwD0DyiVvAjp04PlYtBSQeh8I5cux16yqPYicg_j2uWnFCnFar_Wa0MwhdUnJDqRC3pJCZZIJLRoggJKUZoUdoTDPOEyKYOEbjHZLsmFN0FsImQilNixEaFWlOCE3H6PkFvvB0u_Wd0msI2HYez6EH37jWtSvcrwEvXQ-4s3ipavep_Dde1IMzeAnaQ9_Ffe5C5w34cI5OrKoDXBzmBL0v7t5mD8nT6_3jbPqUaEYymlAupDaa50wYpnTOCyKqVFmomOGMMaOkVdqwTIKxwkpOVFrRPIbk1GZUsAm63vvGvz8GCH3ZuKChrlUL3RBKkRMpWU4iyPeg9l0IHmy59a6JGUpKyl2L5V8tRtnVwX-oGjC_okNt8U7396BWUG66wbcx7v-ePwo_efI</recordid><startdate>199308</startdate><enddate>199308</enddate><creator>Baum, B.J.</creator><creator>Hiramatsu, Y.</creator><creator>Kohn, W.G.</creator><creator>Valdez, I.H.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199308</creationdate><title>New Approaches for Determining the Site of Salivary Fluid Secretory Disorders</title><author>Baum, B.J. ; Hiramatsu, Y. ; Kohn, W.G. ; Valdez, I.H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3051-1479cdc4637d3ac64807b2afeb3d4333da9facd359edf7f940a2b1670041f5173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Calcium - metabolism</topic><topic>Cytophotometry</topic><topic>Dentistry</topic><topic>Dopamine</topic><topic>Kinetics</topic><topic>Norepinephrine - biosynthesis</topic><topic>Parotid Gland - metabolism</topic><topic>Parotid Gland - secretion</topic><topic>Quinuclidinyl Benzilate - analogs & derivatives</topic><topic>Rats</topic><topic>Receptors, Muscarinic - metabolism</topic><topic>Saliva - secretion</topic><topic>Salivary Gland Diseases - physiopathology</topic><topic>Sympathetic Nervous System - physiology</topic><toplevel>online_resources</toplevel><creatorcontrib>Baum, B.J.</creatorcontrib><creatorcontrib>Hiramatsu, Y.</creatorcontrib><creatorcontrib>Kohn, W.G.</creatorcontrib><creatorcontrib>Valdez, I.H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Advances in dental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baum, B.J.</au><au>Hiramatsu, Y.</au><au>Kohn, W.G.</au><au>Valdez, I.H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New Approaches for Determining the Site of Salivary Fluid Secretory Disorders</atitle><jtitle>Advances in dental research</jtitle><addtitle>Adv Dent Res</addtitle><date>1993-08</date><risdate>1993</risdate><volume>7</volume><issue>2</issue><spage>220</spage><epage>224</epage><pages>220-224</pages><issn>0895-9374</issn><eissn>1544-0737</eissn><abstract>Considerable progress has been made in understanding the events which underlie salivary fluid secretion. 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| identifier | ISSN: 0895-9374 |
| ispartof | Advances in dental research, 1993-08, Vol.7 (2), p.220-224 |
| issn | 0895-9374 1544-0737 |
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| source | MEDLINE; SAGE Complete A-Z List |
| subjects | Animals Calcium - metabolism Cytophotometry Dentistry Dopamine Kinetics Norepinephrine - biosynthesis Parotid Gland - metabolism Parotid Gland - secretion Quinuclidinyl Benzilate - analogs & derivatives Rats Receptors, Muscarinic - metabolism Saliva - secretion Salivary Gland Diseases - physiopathology Sympathetic Nervous System - physiology |
| title | New Approaches for Determining the Site of Salivary Fluid Secretory Disorders |
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