Distribution of polyamines in human epidermis

Distribution of polyamines in human epidermis

SUMMARY Consecutive sections through the epidermis were cut parallel to its surface, and the polyamine (PA) concentration in each section was measured by liquid chromatography. There was a constant decrease in PA concentration (expressed as nmol/mg DNA) from the deepest layer to the more superficial...

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Veröffentlicht in:British journal of dermatology (1951) 1985-04, Vol.112 (4), p.393-396
Hauptverfasser: EL BAZE, P., MILANO, G., VERRANDO, P., RENEE, N., ORTONNE, J.P.
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Female
Fundamental and applied biological sciences. Psychology
Humans
Polyamines - analysis
Putrescine - analysis
Skin - analysis
Spermidine - analysis
Spermine - analysis
Vertebrates: skin, associated glands, phaneres, light organs, various exocrine glands (salt gland, uropygial gland...), adipose tissue, connective tissue
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Zusammenfassung:SUMMARY Consecutive sections through the epidermis were cut parallel to its surface, and the polyamine (PA) concentration in each section was measured by liquid chromatography. There was a constant decrease in PA concentration (expressed as nmol/mg DNA) from the deepest layer to the more superficial layers. Putrescine showed the greatest increase (+83%) (P < 0.02): The elevations of spermidine and spermine levels were less marked, respectively +30% (P < 0.05) and + 27% (NS). Proliferating cells in the basal layer possess high polyamine levels and as they mature in the superficial layers their polyamine content decreases.
ISSN:0007-0963
1365-2133
DOI:10.1111/j.1365-2133.1985.tb02311.x