The effect of cholinergic agonists on coronary flow rate and oxygen consumption in isolated perfused rat heart

The metabolic and circulatory consequences of activation of the muscarinic receptor(s) were investigated by local administration of acetylcholine and its three analogues (bethanechol, carbachol and methacholine) into bearing and KCl-arrested perfused rat hearts. Acetylcholine and the three other cho...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 1985, Vol.17 (1), p.31-42
Hauptverfasser:	Nuutinen, E. Matti, Wilson, David F., Erecińska, Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic blockers Animals Bethanechol Bethanechol Compounds - pharmacology Calcium Calcium - pharmacology Carbachol - pharmacology Cardiac Pacing, Artificial Choline - pharmacology Cholinergic agonists Coronary Circulation - drug effects Coronary flow Dose-Response Relationship, Drug Energy Metabolism - drug effects Heart Rate - drug effects Male Muscarinic receptor Myocardium - metabolism Oxygen consumption Oxygen Consumption - drug effects Perfusion Prazosin - pharmacology Propranolol - pharmacology Rats Rats, Inbred Strains Receptors, Muscarinic - drug effects Verapamil Verapamil - pharmacology
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