Effects of diltiazem on cardiac function and regional blood flow at rest and during exercise in a conscious rat preparation of chronic heart failure (myocardial infarction)
The effects of intravenous infusion of diltiazem on regional blood flow (radioactive microspheres), hemodynamics, and maximum rate of oxygen consumption were evaluated in conscious rats with congestive heart failure caused by large myocardial infarction (n = 10, infarct size 41.8% of left ventricle)...
Gespeichert in:
| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 1985-06, Vol.71 (6), p.1262-1270 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1270 |
|---|---|
| container_issue | 6 |
| container_start_page | 1262 |
| container_title | Circulation (New York, N.Y.) |
| container_volume | 71 |
| creator | DREXLER, H DEPENBUSCH, J. W TRUOG, A. G ZELIS, R FLAIM, S. F |
| description | The effects of intravenous infusion of diltiazem on regional blood flow (radioactive microspheres), hemodynamics, and maximum rate of oxygen consumption were evaluated in conscious rats with congestive heart failure caused by large myocardial infarction (n = 10, infarct size 41.8% of left ventricle) and compared with data obtained from rats subjected to sham surgical procedures (n = 9). In both groups data were obtained at rest and during submaximal treadmill exercise during alternate infusion of diltiazem and saline. In the group with heart failure, diltiazem increased stroke volume at rest and during exercise (p less than .05), reduced heart rate (p less than .05), and improved cardiac output during exercise (p less than .05) without increasing left ventricular end-diastolic pressure in any of the animals. Blood flow to renal and splanchnic circulations was reduced in the group with heart failure but was increased by diltiazem to values similar to those observed in sham-operated animals. Although skeletal muscle flow during exercise was significantly increased by the drug, maximal rate of oxygen consumption was not, indicating unchanged oxygen availability within working muscle. Thus diltiazem caused redistribution of blood flow to kidney and gut in animals with myocardial infarction and failure, thereby restoring blood flow to circulatory beds known to be impaired in this setting. |
| doi_str_mv | 10.1161/01.CIR.71.6.1262 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76094399</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>76094399</sourcerecordid><originalsourceid>FETCH-LOGICAL-c406t-42d6bb056bf80192eb30dea33d5b848e4660391448be0b276dd65699161bb8803</originalsourceid><addsrcrecordid>eNo9UU1v1DAQtRBVWdreuSD5gFA5JNix48THalWgUiUkBGfLn62REy92otL-Jn4ks91VTx7Pe_Pm4yH0jpKWUkE_E9pub360A21FSzvRvUIb2ne84T2Tr9GGECKbgXXdG_S21t_wFWzoT9Epk7IfaL9B_65D8HapOAfsYlqifvITzjO2urioLQ7rbJcICT07XPwdhDphk3J2OKT8gPUC6bo8424tcb7D_q8vNlaPI5Rhm-dqY14rLsDdFb_TEOwloae9L3mOFt97XRYcdExr8fhyesyHARJoBF2eR_h0jk6CTtVfHN8z9OvL9c_tt-b2-9eb7dVtYzkRS8M7J4whvTBhJFR23jDivGbM9Wbko-dCECYp56PxxHSDcE70Qko4qDHjSNgZ-njQ3ZX8Z4Xl1BSr9Snp2cMeahBEcjghEMmBaEuutfigdiVOujwqStTeIEWoAoPUQJVQe4Og5P1RezWTdy8FR0cA_3DEdbU6haJnOOULTXZEcD6w_3DAmyg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76094399</pqid></control><display><type>article</type><title>Effects of diltiazem on cardiac function and regional blood flow at rest and during exercise in a conscious rat preparation of chronic heart failure (myocardial infarction)</title><source>MEDLINE</source><source>American Heart Association Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Journals@Ovid Complete</source><creator>DREXLER, H ; DEPENBUSCH, J. W ; TRUOG, A. G ; ZELIS, R ; FLAIM, S. F</creator><creatorcontrib>DREXLER, H ; DEPENBUSCH, J. W ; TRUOG, A. G ; ZELIS, R ; FLAIM, S. F</creatorcontrib><description>The effects of intravenous infusion of diltiazem on regional blood flow (radioactive microspheres), hemodynamics, and maximum rate of oxygen consumption were evaluated in conscious rats with congestive heart failure caused by large myocardial infarction (n = 10, infarct size 41.8% of left ventricle) and compared with data obtained from rats subjected to sham surgical procedures (n = 9). In both groups data were obtained at rest and during submaximal treadmill exercise during alternate infusion of diltiazem and saline. In the group with heart failure, diltiazem increased stroke volume at rest and during exercise (p less than .05), reduced heart rate (p less than .05), and improved cardiac output during exercise (p less than .05) without increasing left ventricular end-diastolic pressure in any of the animals. Blood flow to renal and splanchnic circulations was reduced in the group with heart failure but was increased by diltiazem to values similar to those observed in sham-operated animals. Although skeletal muscle flow during exercise was significantly increased by the drug, maximal rate of oxygen consumption was not, indicating unchanged oxygen availability within working muscle. Thus diltiazem caused redistribution of blood flow to kidney and gut in animals with myocardial infarction and failure, thereby restoring blood flow to circulatory beds known to be impaired in this setting.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.CIR.71.6.1262</identifier><identifier>PMID: 3995715</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Animals ; Antianginal agents. Coronary vasodilator agents ; Benzazepines - therapeutic use ; Biological and medical sciences ; Cardiovascular system ; Diltiazem - therapeutic use ; Heart Failure - drug therapy ; Heart Failure - physiopathology ; Hemodynamics - drug effects ; Male ; Medical sciences ; Myocardial Infarction - drug therapy ; Myocardial Infarction - physiopathology ; Oxygen Consumption - drug effects ; Pharmacology. Drug treatments ; Physical Exertion ; Rats ; Rats, Inbred Strains ; Regional Blood Flow - drug effects</subject><ispartof>Circulation (New York, N.Y.), 1985-06, Vol.71 (6), p.1262-1270</ispartof><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-42d6bb056bf80192eb30dea33d5b848e4660391448be0b276dd65699161bb8803</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3687,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9206447$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3995715$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DREXLER, H</creatorcontrib><creatorcontrib>DEPENBUSCH, J. W</creatorcontrib><creatorcontrib>TRUOG, A. G</creatorcontrib><creatorcontrib>ZELIS, R</creatorcontrib><creatorcontrib>FLAIM, S. F</creatorcontrib><title>Effects of diltiazem on cardiac function and regional blood flow at rest and during exercise in a conscious rat preparation of chronic heart failure (myocardial infarction)</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>The effects of intravenous infusion of diltiazem on regional blood flow (radioactive microspheres), hemodynamics, and maximum rate of oxygen consumption were evaluated in conscious rats with congestive heart failure caused by large myocardial infarction (n = 10, infarct size 41.8% of left ventricle) and compared with data obtained from rats subjected to sham surgical procedures (n = 9). In both groups data were obtained at rest and during submaximal treadmill exercise during alternate infusion of diltiazem and saline. In the group with heart failure, diltiazem increased stroke volume at rest and during exercise (p less than .05), reduced heart rate (p less than .05), and improved cardiac output during exercise (p less than .05) without increasing left ventricular end-diastolic pressure in any of the animals. Blood flow to renal and splanchnic circulations was reduced in the group with heart failure but was increased by diltiazem to values similar to those observed in sham-operated animals. Although skeletal muscle flow during exercise was significantly increased by the drug, maximal rate of oxygen consumption was not, indicating unchanged oxygen availability within working muscle. Thus diltiazem caused redistribution of blood flow to kidney and gut in animals with myocardial infarction and failure, thereby restoring blood flow to circulatory beds known to be impaired in this setting.</description><subject>Animals</subject><subject>Antianginal agents. Coronary vasodilator agents</subject><subject>Benzazepines - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular system</subject><subject>Diltiazem - therapeutic use</subject><subject>Heart Failure - drug therapy</subject><subject>Heart Failure - physiopathology</subject><subject>Hemodynamics - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Myocardial Infarction - drug therapy</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Oxygen Consumption - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Physical Exertion</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Regional Blood Flow - drug effects</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UU1v1DAQtRBVWdreuSD5gFA5JNix48THalWgUiUkBGfLn62REy92otL-Jn4ks91VTx7Pe_Pm4yH0jpKWUkE_E9pub360A21FSzvRvUIb2ne84T2Tr9GGECKbgXXdG_S21t_wFWzoT9Epk7IfaL9B_65D8HapOAfsYlqifvITzjO2urioLQ7rbJcICT07XPwdhDphk3J2OKT8gPUC6bo8424tcb7D_q8vNlaPI5Rhm-dqY14rLsDdFb_TEOwloae9L3mOFt97XRYcdExr8fhyesyHARJoBF2eR_h0jk6CTtVfHN8z9OvL9c_tt-b2-9eb7dVtYzkRS8M7J4whvTBhJFR23jDivGbM9Wbko-dCECYp56PxxHSDcE70Qko4qDHjSNgZ-njQ3ZX8Z4Xl1BSr9Snp2cMeahBEcjghEMmBaEuutfigdiVOujwqStTeIEWoAoPUQJVQe4Og5P1RezWTdy8FR0cA_3DEdbU6haJnOOULTXZEcD6w_3DAmyg</recordid><startdate>198506</startdate><enddate>198506</enddate><creator>DREXLER, H</creator><creator>DEPENBUSCH, J. W</creator><creator>TRUOG, A. G</creator><creator>ZELIS, R</creator><creator>FLAIM, S. F</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198506</creationdate><title>Effects of diltiazem on cardiac function and regional blood flow at rest and during exercise in a conscious rat preparation of chronic heart failure (myocardial infarction)</title><author>DREXLER, H ; DEPENBUSCH, J. W ; TRUOG, A. G ; ZELIS, R ; FLAIM, S. F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-42d6bb056bf80192eb30dea33d5b848e4660391448be0b276dd65699161bb8803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Antianginal agents. Coronary vasodilator agents</topic><topic>Benzazepines - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular system</topic><topic>Diltiazem - therapeutic use</topic><topic>Heart Failure - drug therapy</topic><topic>Heart Failure - physiopathology</topic><topic>Hemodynamics - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Myocardial Infarction - drug therapy</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Oxygen Consumption - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Physical Exertion</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Regional Blood Flow - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DREXLER, H</creatorcontrib><creatorcontrib>DEPENBUSCH, J. W</creatorcontrib><creatorcontrib>TRUOG, A. G</creatorcontrib><creatorcontrib>ZELIS, R</creatorcontrib><creatorcontrib>FLAIM, S. F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DREXLER, H</au><au>DEPENBUSCH, J. W</au><au>TRUOG, A. G</au><au>ZELIS, R</au><au>FLAIM, S. F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of diltiazem on cardiac function and regional blood flow at rest and during exercise in a conscious rat preparation of chronic heart failure (myocardial infarction)</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>1985-06</date><risdate>1985</risdate><volume>71</volume><issue>6</issue><spage>1262</spage><epage>1270</epage><pages>1262-1270</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>The effects of intravenous infusion of diltiazem on regional blood flow (radioactive microspheres), hemodynamics, and maximum rate of oxygen consumption were evaluated in conscious rats with congestive heart failure caused by large myocardial infarction (n = 10, infarct size 41.8% of left ventricle) and compared with data obtained from rats subjected to sham surgical procedures (n = 9). In both groups data were obtained at rest and during submaximal treadmill exercise during alternate infusion of diltiazem and saline. In the group with heart failure, diltiazem increased stroke volume at rest and during exercise (p less than .05), reduced heart rate (p less than .05), and improved cardiac output during exercise (p less than .05) without increasing left ventricular end-diastolic pressure in any of the animals. Blood flow to renal and splanchnic circulations was reduced in the group with heart failure but was increased by diltiazem to values similar to those observed in sham-operated animals. Although skeletal muscle flow during exercise was significantly increased by the drug, maximal rate of oxygen consumption was not, indicating unchanged oxygen availability within working muscle. Thus diltiazem caused redistribution of blood flow to kidney and gut in animals with myocardial infarction and failure, thereby restoring blood flow to circulatory beds known to be impaired in this setting.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>3995715</pmid><doi>10.1161/01.CIR.71.6.1262</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-7322 |
| ispartof | Circulation (New York, N.Y.), 1985-06, Vol.71 (6), p.1262-1270 |
| issn | 0009-7322 1524-4539 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76094399 |
| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Animals Antianginal agents. Coronary vasodilator agents Benzazepines - therapeutic use Biological and medical sciences Cardiovascular system Diltiazem - therapeutic use Heart Failure - drug therapy Heart Failure - physiopathology Hemodynamics - drug effects Male Medical sciences Myocardial Infarction - drug therapy Myocardial Infarction - physiopathology Oxygen Consumption - drug effects Pharmacology. Drug treatments Physical Exertion Rats Rats, Inbred Strains Regional Blood Flow - drug effects |
| title | Effects of diltiazem on cardiac function and regional blood flow at rest and during exercise in a conscious rat preparation of chronic heart failure (myocardial infarction) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T21%3A24%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20diltiazem%20on%20cardiac%20function%20and%20regional%20blood%20flow%20at%20rest%20and%20during%20exercise%20in%20a%20conscious%20rat%20preparation%20of%20chronic%20heart%20failure%20(myocardial%20infarction)&rft.jtitle=Circulation%20(New%20York,%20N.Y.)&rft.au=DREXLER,%20H&rft.date=1985-06&rft.volume=71&rft.issue=6&rft.spage=1262&rft.epage=1270&rft.pages=1262-1270&rft.issn=0009-7322&rft.eissn=1524-4539&rft.coden=CIRCAZ&rft_id=info:doi/10.1161/01.CIR.71.6.1262&rft_dat=%3Cproquest_cross%3E76094399%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=76094399&rft_id=info:pmid/3995715&rfr_iscdi=true |