Loss of M2 Muscarine Receptors in the Cerebral Cortex in Alzheimer's Disease and Experimental Cholinergic Denervation

Cerebral cortex samples from patients with Alzheimer's disease and from rats after experimental cholinergic denervation of the cerebral cortex exhibited reductions in the presynaptic marker choline acetyltransferase activity and in the number of M2 muscarine receptors, with no change in the num...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 1985-05, Vol.228 (4703), p.1115-1117
Hauptverfasser:	Mash, Deborah C., Flynn, Donna D., Potter, Lincoln T.
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylcholine Aged Agonists Alzheimer Disease - metabolism Alzheimer's disease Alzheimers disease Animals Biological and medical sciences Brain Brain research Causes of Cerebral cortex Cerebral Cortex - metabolism Choline O-Acetyltransferase - metabolism Cholinergic Fibers - physiology Cholinergics cortex Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Denervation Humans Lesions Male man Medical sciences Nerves Neurology Neuroscience Oxotremorine Quinuclidinyl Benzilate Rats Rats, Inbred Strains Receptors Receptors, Muscarinic - metabolism Synaptic Membranes - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!