Loss of M2 Muscarine Receptors in the Cerebral Cortex in Alzheimer's Disease and Experimental Cholinergic Denervation
Cerebral cortex samples from patients with Alzheimer's disease and from rats after experimental cholinergic denervation of the cerebral cortex exhibited reductions in the presynaptic marker choline acetyltransferase activity and in the number of M2 muscarine receptors, with no change in the num...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1985-05, Vol.228 (4703), p.1115-1117 |
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| creator | Mash, Deborah C. Flynn, Donna D. Potter, Lincoln T. |
| description | Cerebral cortex samples from patients with Alzheimer's disease and from rats after experimental cholinergic denervation of the cerebral cortex exhibited reductions in the presynaptic marker choline acetyltransferase activity and in the number of M2 muscarine receptors, with no change in the number of M1 receptors. These results are in keeping with evidence that M2 receptors function in cholinergic nerve terminals to regulate the release of acetylcholine, whereas M1 receptors are located on postsynaptic cells and facilitate cellular excitation. New M1-selective agonists and M2-selective antagonists directed at post- or presynaptic sites deserve consideration as potential agents for the treatment of the disease. |
| doi_str_mv | 10.1126/science.3992249 |
| format | Article |
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These results are in keeping with evidence that M2 receptors function in cholinergic nerve terminals to regulate the release of acetylcholine, whereas M1 receptors are located on postsynaptic cells and facilitate cellular excitation. New M1-selective agonists and M2-selective antagonists directed at post- or presynaptic sites deserve consideration as potential agents for the treatment of the disease.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.3992249</identifier><identifier>PMID: 3992249</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: The American Association for the Advancement of Science</publisher><subject>acetylcholine ; Aged ; Agonists ; Alzheimer Disease - metabolism ; Alzheimer's disease ; Alzheimers disease ; Animals ; Biological and medical sciences ; Brain ; Brain research ; Causes of ; Cerebral cortex ; Cerebral Cortex - metabolism ; Choline O-Acetyltransferase - metabolism ; Cholinergic Fibers - physiology ; Cholinergics ; cortex ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Denervation ; Humans ; Lesions ; Male ; man ; Medical sciences ; Nerves ; Neurology ; Neuroscience ; Oxotremorine ; Quinuclidinyl Benzilate ; Rats ; Rats, Inbred Strains ; Receptors ; Receptors, Muscarinic - metabolism ; Synaptic Membranes - metabolism</subject><ispartof>Science (American Association for the Advancement of Science), 1985-05, Vol.228 (4703), p.1115-1117</ispartof><rights>Copyright 1985 The American Association for the Advancement of Science</rights><rights>1985 INIST-CNRS</rights><rights>COPYRIGHT 1985 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1985 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c707t-d96f1f6d6c216b0b9bed3e64950dfe73abf035dee1bdc9c2b468a8a1322f29513</citedby><cites>FETCH-LOGICAL-c707t-d96f1f6d6c216b0b9bed3e64950dfe73abf035dee1bdc9c2b468a8a1322f29513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1694304$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1694304$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2883,2884,27923,27924,58016,58249</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9216738$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3992249$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mash, Deborah C.</creatorcontrib><creatorcontrib>Flynn, Donna D.</creatorcontrib><creatorcontrib>Potter, Lincoln T.</creatorcontrib><title>Loss of M2 Muscarine Receptors in the Cerebral Cortex in Alzheimer's Disease and Experimental Cholinergic Denervation</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Cerebral cortex samples from patients with Alzheimer's disease and from rats after experimental cholinergic denervation of the cerebral cortex exhibited reductions in the presynaptic marker choline acetyltransferase activity and in the number of M2 muscarine receptors, with no change in the number of M1 receptors. These results are in keeping with evidence that M2 receptors function in cholinergic nerve terminals to regulate the release of acetylcholine, whereas M1 receptors are located on postsynaptic cells and facilitate cellular excitation. New M1-selective agonists and M2-selective antagonists directed at post- or presynaptic sites deserve consideration as potential agents for the treatment of the disease.</description><subject>acetylcholine</subject><subject>Aged</subject><subject>Agonists</subject><subject>Alzheimer Disease - metabolism</subject><subject>Alzheimer's disease</subject><subject>Alzheimers disease</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain research</subject><subject>Causes of</subject><subject>Cerebral cortex</subject><subject>Cerebral Cortex - metabolism</subject><subject>Choline O-Acetyltransferase - metabolism</subject><subject>Cholinergic Fibers - physiology</subject><subject>Cholinergics</subject><subject>cortex</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Denervation</subject><subject>Humans</subject><subject>Lesions</subject><subject>Male</subject><subject>man</subject><subject>Medical sciences</subject><subject>Nerves</subject><subject>Neurology</subject><subject>Neuroscience</subject><subject>Oxotremorine</subject><subject>Quinuclidinyl Benzilate</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptors</subject><subject>Receptors, Muscarinic - metabolism</subject><subject>Synaptic Membranes - metabolism</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0s9v0zAUB3ALgUZXOHMByQfEDiObHSdOfCzdKJM6KvHrGjnOc-vJjYudTIO_HpdG25AqUeXg6L2PHcXvi9ArSs4oTfl5UAZaBWdMiDTNxBM0okTkiUgJe4pGhDCelKTIn6PjEG4IiT3BjtDRwEeon7sQsNP4OsXXfVDSmxbwF1Cw6ZwP2LS4WwGegofaS4unzndwty1P7O8VmDX4k4AvTAAZAMu2wZd3G_Cx3nZbvnI2HuiXRuELiC-3sjOufYGeaWkDvBzWMfr-8fLb9FMyX8yuppN5ogpSdEkjuKaaN1yllNekFjU0DHgmctJoKJisNWF5A0DrRgmV1hkvZSkpS1OdipyyMXq3O3fj3c8eQletTVBgrWzB9aEqOBEZY-V_Ic1owbd3N0anO7iUFirTatd5qZbbX5PWtaBNLE9YIQgr8qjf79HxaWBt1B5-8g-PIl52t5R9CNXV18-HysWPQ-WH2YGynM0fy9N9UjlrYQlVHOF08Vif77TyMWsedLWJ-ZD-V0VJtQ1xNYS4GlIZd7wZptHXa2ju_UP_7dCXMbFWe9kqE-6ZiGkp_g719Y7dhJjlh6_yOHOSsT_xSgHX</recordid><startdate>19850531</startdate><enddate>19850531</enddate><creator>Mash, Deborah C.</creator><creator>Flynn, Donna D.</creator><creator>Potter, Lincoln T.</creator><general>The American Association for the Advancement of Science</general><general>American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19850531</creationdate><title>Loss of M2 Muscarine Receptors in the Cerebral Cortex in Alzheimer's Disease and Experimental Cholinergic Denervation</title><author>Mash, Deborah C. ; Flynn, Donna D. ; Potter, Lincoln T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c707t-d96f1f6d6c216b0b9bed3e64950dfe73abf035dee1bdc9c2b468a8a1322f29513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>acetylcholine</topic><topic>Aged</topic><topic>Agonists</topic><topic>Alzheimer Disease - metabolism</topic><topic>Alzheimer's disease</topic><topic>Alzheimers disease</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Brain research</topic><topic>Causes of</topic><topic>Cerebral cortex</topic><topic>Cerebral Cortex - metabolism</topic><topic>Choline O-Acetyltransferase - metabolism</topic><topic>Cholinergic Fibers - physiology</topic><topic>Cholinergics</topic><topic>cortex</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Denervation</topic><topic>Humans</topic><topic>Lesions</topic><topic>Male</topic><topic>man</topic><topic>Medical sciences</topic><topic>Nerves</topic><topic>Neurology</topic><topic>Neuroscience</topic><topic>Oxotremorine</topic><topic>Quinuclidinyl Benzilate</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Receptors</topic><topic>Receptors, Muscarinic - metabolism</topic><topic>Synaptic Membranes - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mash, Deborah C.</creatorcontrib><creatorcontrib>Flynn, Donna D.</creatorcontrib><creatorcontrib>Potter, Lincoln T.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Gale In Context: Biography</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mash, Deborah C.</au><au>Flynn, Donna D.</au><au>Potter, Lincoln T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Loss of M2 Muscarine Receptors in the Cerebral Cortex in Alzheimer's Disease and Experimental Cholinergic Denervation</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1985-05-31</date><risdate>1985</risdate><volume>228</volume><issue>4703</issue><spage>1115</spage><epage>1117</epage><pages>1115-1117</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Cerebral cortex samples from patients with Alzheimer's disease and from rats after experimental cholinergic denervation of the cerebral cortex exhibited reductions in the presynaptic marker choline acetyltransferase activity and in the number of M2 muscarine receptors, with no change in the number of M1 receptors. These results are in keeping with evidence that M2 receptors function in cholinergic nerve terminals to regulate the release of acetylcholine, whereas M1 receptors are located on postsynaptic cells and facilitate cellular excitation. New M1-selective agonists and M2-selective antagonists directed at post- or presynaptic sites deserve consideration as potential agents for the treatment of the disease.</abstract><cop>Washington, DC</cop><pub>The American Association for the Advancement of Science</pub><pmid>3992249</pmid><doi>10.1126/science.3992249</doi><tpages>3</tpages></addata></record> |
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| issn | 0036-8075 1095-9203 |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science |
| subjects | acetylcholine Aged Agonists Alzheimer Disease - metabolism Alzheimer's disease Alzheimers disease Animals Biological and medical sciences Brain Brain research Causes of Cerebral cortex Cerebral Cortex - metabolism Choline O-Acetyltransferase - metabolism Cholinergic Fibers - physiology Cholinergics cortex Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Denervation Humans Lesions Male man Medical sciences Nerves Neurology Neuroscience Oxotremorine Quinuclidinyl Benzilate Rats Rats, Inbred Strains Receptors Receptors, Muscarinic - metabolism Synaptic Membranes - metabolism |
| title | Loss of M2 Muscarine Receptors in the Cerebral Cortex in Alzheimer's Disease and Experimental Cholinergic Denervation |
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