Amplification and Overexpression of EXP1 and EXP2/Cyclin D1 Genes in Human Esophageal Carcinomas
We previously identified two genes, EXP1 and EXP2/Cyclin D1, about 120 kb apart from HST1 and INT2 on human chromosome 11q13. Here we report the frequent amplification and overexpression of these genes in surgically resected esophageal carcinomas. Amplification was observed in 8 out of 22 cases. In...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1993-11, Vol.196 (3), p.1529-1536 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Tsuruta, H. Sakamoto, H. Onda, M. Terada, M. |
| description | We previously identified two genes,
EXP1 and
EXP2/Cyclin D1, about 120 kb apart from
HST1 and
INT2 on human chromosome 11q13. Here we report the frequent amplification and overexpression of these genes in surgically resected esophageal carcinomas. Amplification was observed in 8 out of 22 cases. In the tumors with the amplification, these genes were overexpressed, while in the tumors without the amplification, expression levels of these genes were almost the same as those with normal mucosa. These results suggest that
EXP1 and/or
EXP2/Cyclin D1 may play an important role in the progression of human esophageal carcinomas. |
| doi_str_mv | 10.1006/bbrc.1993.2425 |
| format | Article |
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EXP1 and
EXP2/Cyclin D1, about 120 kb apart from
HST1 and
INT2 on human chromosome 11q13. Here we report the frequent amplification and overexpression of these genes in surgically resected esophageal carcinomas. Amplification was observed in 8 out of 22 cases. In the tumors with the amplification, these genes were overexpressed, while in the tumors without the amplification, expression levels of these genes were almost the same as those with normal mucosa. These results suggest that
EXP1 and/or
EXP2/Cyclin D1 may play an important role in the progression of human esophageal carcinomas.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1006/bbrc.1993.2425</identifier><identifier>PMID: 8250909</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Base Sequence ; Chromosome Mapping ; Chromosomes, Human, Pair 11 ; Cyclin D1 ; Cyclins - biosynthesis ; Cyclins - genetics ; DNA Primers ; Esophageal Neoplasms - genetics ; Esophageal Neoplasms - metabolism ; Esophageal Neoplasms - surgery ; Esophagus - metabolism ; Female ; Gene Amplification ; Gene Expression ; Humans ; Male ; Middle Aged ; Molecular Sequence Data ; Mucous Membrane - metabolism ; Oligonucleotide Probes ; Oncogene Proteins - biosynthesis ; Oncogene Proteins - genetics ; Open Reading Frames ; Polymerase Chain Reaction ; Protein Biosynthesis ; Proteins - genetics</subject><ispartof>Biochemical and biophysical research communications, 1993-11, Vol.196 (3), p.1529-1536</ispartof><rights>1993 Academic Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-e93ee1ca78f0253e85d840e691cc219368c2b57cbf61f82c9b14df563f21da303</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1006/bbrc.1993.2425$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8250909$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsuruta, H.</creatorcontrib><creatorcontrib>Sakamoto, H.</creatorcontrib><creatorcontrib>Onda, M.</creatorcontrib><creatorcontrib>Terada, M.</creatorcontrib><title>Amplification and Overexpression of EXP1 and EXP2/Cyclin D1 Genes in Human Esophageal Carcinomas</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>We previously identified two genes,
EXP1 and
EXP2/Cyclin D1, about 120 kb apart from
HST1 and
INT2 on human chromosome 11q13. Here we report the frequent amplification and overexpression of these genes in surgically resected esophageal carcinomas. Amplification was observed in 8 out of 22 cases. In the tumors with the amplification, these genes were overexpressed, while in the tumors without the amplification, expression levels of these genes were almost the same as those with normal mucosa. These results suggest that
EXP1 and/or
EXP2/Cyclin D1 may play an important role in the progression of human esophageal carcinomas.</description><subject>Adult</subject><subject>Aged</subject><subject>Base Sequence</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, Pair 11</subject><subject>Cyclin D1</subject><subject>Cyclins - biosynthesis</subject><subject>Cyclins - genetics</subject><subject>DNA Primers</subject><subject>Esophageal Neoplasms - genetics</subject><subject>Esophageal Neoplasms - metabolism</subject><subject>Esophageal Neoplasms - surgery</subject><subject>Esophagus - metabolism</subject><subject>Female</subject><subject>Gene Amplification</subject><subject>Gene Expression</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Molecular Sequence Data</subject><subject>Mucous Membrane - metabolism</subject><subject>Oligonucleotide Probes</subject><subject>Oncogene Proteins - biosynthesis</subject><subject>Oncogene Proteins - genetics</subject><subject>Open Reading Frames</subject><subject>Polymerase Chain Reaction</subject><subject>Protein Biosynthesis</subject><subject>Proteins - genetics</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1PwzAQhi0EKqWwsiFlYkvrs5M0HqtSWqRKZQCpm3GcMxjlC7up6L8noRUbk09-n3ulewi5BToGSpNJljk9BiH4mEUsPiNDoIKGDGh0Toa0I0ImYHtJrrz_pBQgSsSADFIWd5gYkrdZ2RTWWK12tq4CVeXBZo8OvxuH3vdftQkW22f4jbqBTeYHXdgqeIBgiRX6oJtXbamqYOHr5kO9oyqCuXLaVnWp_DW5MKrweHN6R-T1cfEyX4XrzfJpPluHOuLRLkTBEUGraWooizmmcZ5GFBMBWjMQPEk1y-KpzkwCJmVaZBDlJk64YZArTvmI3B97G1d_teh3srReY1GoCuvWy2lCBY8T1oHjI6hd7b1DIxtnS-UOEqjslcpeqeyVyl5pt3B3am6zEvM__OSwy9Njjt15e4tOem2x0phbh3on89r-V_0DD_qENw</recordid><startdate>19931115</startdate><enddate>19931115</enddate><creator>Tsuruta, H.</creator><creator>Sakamoto, H.</creator><creator>Onda, M.</creator><creator>Terada, M.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19931115</creationdate><title>Amplification and Overexpression of EXP1 and EXP2/Cyclin D1 Genes in Human Esophageal Carcinomas</title><author>Tsuruta, H. ; Sakamoto, H. ; Onda, M. ; Terada, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-e93ee1ca78f0253e85d840e691cc219368c2b57cbf61f82c9b14df563f21da303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Base Sequence</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Human, Pair 11</topic><topic>Cyclin D1</topic><topic>Cyclins - biosynthesis</topic><topic>Cyclins - genetics</topic><topic>DNA Primers</topic><topic>Esophageal Neoplasms - genetics</topic><topic>Esophageal Neoplasms - metabolism</topic><topic>Esophageal Neoplasms - surgery</topic><topic>Esophagus - metabolism</topic><topic>Female</topic><topic>Gene Amplification</topic><topic>Gene Expression</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Molecular Sequence Data</topic><topic>Mucous Membrane - metabolism</topic><topic>Oligonucleotide Probes</topic><topic>Oncogene Proteins - biosynthesis</topic><topic>Oncogene Proteins - genetics</topic><topic>Open Reading Frames</topic><topic>Polymerase Chain Reaction</topic><topic>Protein Biosynthesis</topic><topic>Proteins - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsuruta, H.</creatorcontrib><creatorcontrib>Sakamoto, H.</creatorcontrib><creatorcontrib>Onda, M.</creatorcontrib><creatorcontrib>Terada, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsuruta, H.</au><au>Sakamoto, H.</au><au>Onda, M.</au><au>Terada, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amplification and Overexpression of EXP1 and EXP2/Cyclin D1 Genes in Human Esophageal Carcinomas</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1993-11-15</date><risdate>1993</risdate><volume>196</volume><issue>3</issue><spage>1529</spage><epage>1536</epage><pages>1529-1536</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>We previously identified two genes,
EXP1 and
EXP2/Cyclin D1, about 120 kb apart from
HST1 and
INT2 on human chromosome 11q13. Here we report the frequent amplification and overexpression of these genes in surgically resected esophageal carcinomas. Amplification was observed in 8 out of 22 cases. In the tumors with the amplification, these genes were overexpressed, while in the tumors without the amplification, expression levels of these genes were almost the same as those with normal mucosa. These results suggest that
EXP1 and/or
EXP2/Cyclin D1 may play an important role in the progression of human esophageal carcinomas.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>8250909</pmid><doi>10.1006/bbrc.1993.2425</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0006-291X |
| ispartof | Biochemical and biophysical research communications, 1993-11, Vol.196 (3), p.1529-1536 |
| issn | 0006-291X 1090-2104 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76093562 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Aged Base Sequence Chromosome Mapping Chromosomes, Human, Pair 11 Cyclin D1 Cyclins - biosynthesis Cyclins - genetics DNA Primers Esophageal Neoplasms - genetics Esophageal Neoplasms - metabolism Esophageal Neoplasms - surgery Esophagus - metabolism Female Gene Amplification Gene Expression Humans Male Middle Aged Molecular Sequence Data Mucous Membrane - metabolism Oligonucleotide Probes Oncogene Proteins - biosynthesis Oncogene Proteins - genetics Open Reading Frames Polymerase Chain Reaction Protein Biosynthesis Proteins - genetics |
| title | Amplification and Overexpression of EXP1 and EXP2/Cyclin D1 Genes in Human Esophageal Carcinomas |
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