Inducibility and negative autoregulation of CREM: An alternative promoter directs the expression of ICER, an early response repressor

cAMP-responsive element modulator (CREM) expression is tissue specific and developmentally regulated. Here we report that CREM is unique within the family of cAMP-responsive promoter element (CRE)-binding factors since it is inducible by activation of the cAMP signaling pathway. The kinetic of expre...

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Veröffentlicht in:	Cell 1993-12, Vol.75 (5), p.875-886
Hauptverfasser:	Molina, Carlos A., Foulkes, Nicholas S., Lalli, Enzo, Sassone-Corsi, Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - physiology Alternative Splicing Amino Acid Sequence Animals Base Sequence Biological and medical sciences Cloning, Molecular Cyclic AMP - physiology Cyclic AMP Response Element Modulator DNA-Binding Proteins - genetics Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation Introns Male Molecular and cellular biology Molecular genetics Molecular Sequence Data Nuclear Proteins - genetics Promoter Regions, Genetic Rats Rats, Wistar Receptors, Cyclic AMP - physiology Repressor Proteins - genetics RNA, Messenger - genetics Signal Transduction Time Factors
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