Inducibility and negative autoregulation of CREM: An alternative promoter directs the expression of ICER, an early response repressor
cAMP-responsive element modulator (CREM) expression is tissue specific and developmentally regulated. Here we report that CREM is unique within the family of cAMP-responsive promoter element (CRE)-binding factors since it is inducible by activation of the cAMP signaling pathway. The kinetic of expre...
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| Veröffentlicht in: | Cell 1993-12, Vol.75 (5), p.875-886 |
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| creator | Molina, Carlos A. Foulkes, Nicholas S. Lalli, Enzo Sassone-Corsi, Paolo |
| description | cAMP-responsive element modulator (CREM) expression is tissue specific and developmentally regulated. Here we report that CREM is unique within the family of cAMP-responsive promoter element (CRE)-binding factors since it is inducible by activation of the cAMP signaling pathway. The kinetic of expression is characteristic of an early response gene. The induction is transient and cell specific, does not involve increased transcript stability, and does not require protein synthesis. Significantly, the subsequent decline in CREM expression requires de novo protein synthesis. The induced transcript encodes a novel repressor, inducible cAMP early repressor (ICER), and is generated from an alternative intronic promoter. A cluster of four CREs in this promoter directs cAMP inducibility. ICER binds to these elements and thereby represses the activity of its own promoter, thus constituting a negative autoregulatory loop. |
| doi_str_mv | 10.1016/0092-8674(93)90532-U |
| format | Article |
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Here we report that CREM is unique within the family of cAMP-responsive promoter element (CRE)-binding factors since it is inducible by activation of the cAMP signaling pathway. The kinetic of expression is characteristic of an early response gene. The induction is transient and cell specific, does not involve increased transcript stability, and does not require protein synthesis. Significantly, the subsequent decline in CREM expression requires de novo protein synthesis. The induced transcript encodes a novel repressor, inducible cAMP early repressor (ICER), and is generated from an alternative intronic promoter. A cluster of four CREs in this promoter directs cAMP inducibility. 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Here we report that CREM is unique within the family of cAMP-responsive promoter element (CRE)-binding factors since it is inducible by activation of the cAMP signaling pathway. The kinetic of expression is characteristic of an early response gene. The induction is transient and cell specific, does not involve increased transcript stability, and does not require protein synthesis. Significantly, the subsequent decline in CREM expression requires de novo protein synthesis. The induced transcript encodes a novel repressor, inducible cAMP early repressor (ICER), and is generated from an alternative intronic promoter. A cluster of four CREs in this promoter directs cAMP inducibility. ICER binds to these elements and thereby represses the activity of its own promoter, thus constituting a negative autoregulatory loop.</description><subject>Adenylyl Cyclases - physiology</subject><subject>Alternative Splicing</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Cloning, Molecular</subject><subject>Cyclic AMP - physiology</subject><subject>Cyclic AMP Response Element Modulator</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression</subject><subject>Gene Expression Regulation</subject><subject>Introns</subject><subject>Male</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>Nuclear Proteins - genetics</subject><subject>Promoter Regions, Genetic</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, Cyclic AMP - physiology</subject><subject>Repressor Proteins - genetics</subject><subject>RNA, Messenger - genetics</subject><subject>Signal Transduction</subject><subject>Time Factors</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkd2KFDEQhYMo67j6Bgq5EFGwtZL0T-KFsAyjDqwIi3Md0unqNdKTjEn34jyA7216e5hLvUqK852qog4hzxm8Y8Dq9wCKF7JuytdKvFFQCV7sHpAVA9UUJWv4Q7I6I4_Jk5R-AoCsquqCXEhe8ZqXK_Jn67vJutYNbjxS4zvq8daM7g6pmcYQ8XYachk8DT1d32y-fqBXnpphxOgX7BDDPuSSdi6iHRMdfyDF34eIKZ182_Xm5m1uTtHE4Uizcgg-Yf7cUyE-JY96MyR8dnovye7T5vv6S3H97fN2fXVd2IqrsajBCNbyUkAtwUDPwVpZSyW4KJuSA4IAgbLsWNdUorG8Na00LUqpFGOyFpfk1dI3L_1rwjTqvUsWh8F4DFPSTQ0zWP4XZHXT5KEyg-UC2hhSitjrQ3R7E4-agZ5j0nMGes5AK6HvY9K7bHtx6j-1e-zOplMuWX950k2yZuij8dalMyakqJSYp39cMMxHu3MYdbIOvcUlC90F9-89_gKYOq6r</recordid><startdate>19931203</startdate><enddate>19931203</enddate><creator>Molina, Carlos A.</creator><creator>Foulkes, Nicholas S.</creator><creator>Lalli, Enzo</creator><creator>Sassone-Corsi, Paolo</creator><general>Elsevier Inc</general><general>Cell Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>19931203</creationdate><title>Inducibility and negative autoregulation of CREM: An alternative promoter directs the expression of ICER, an early response repressor</title><author>Molina, Carlos A. ; Foulkes, Nicholas S. ; Lalli, Enzo ; Sassone-Corsi, Paolo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c529t-60a31b2430680a0f20cc868932347420e0303e84d1d7537c2bab8abe889911863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adenylyl Cyclases - physiology</topic><topic>Alternative Splicing</topic><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Cloning, Molecular</topic><topic>Cyclic AMP - physiology</topic><topic>Cyclic AMP Response Element Modulator</topic><topic>DNA-Binding Proteins - genetics</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene expression</topic><topic>Gene Expression Regulation</topic><topic>Introns</topic><topic>Male</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Molecular Sequence Data</topic><topic>Nuclear Proteins - genetics</topic><topic>Promoter Regions, Genetic</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors, Cyclic AMP - physiology</topic><topic>Repressor Proteins - genetics</topic><topic>RNA, Messenger - genetics</topic><topic>Signal Transduction</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Molina, Carlos A.</creatorcontrib><creatorcontrib>Foulkes, Nicholas S.</creatorcontrib><creatorcontrib>Lalli, Enzo</creatorcontrib><creatorcontrib>Sassone-Corsi, Paolo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Molina, Carlos A.</au><au>Foulkes, Nicholas S.</au><au>Lalli, Enzo</au><au>Sassone-Corsi, Paolo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inducibility and negative autoregulation of CREM: An alternative promoter directs the expression of ICER, an early response repressor</atitle><jtitle>Cell</jtitle><addtitle>Cell</addtitle><date>1993-12-03</date><risdate>1993</risdate><volume>75</volume><issue>5</issue><spage>875</spage><epage>886</epage><pages>875-886</pages><issn>0092-8674</issn><eissn>1097-4172</eissn><coden>CELLB5</coden><abstract>cAMP-responsive element modulator (CREM) expression is tissue specific and developmentally regulated. Here we report that CREM is unique within the family of cAMP-responsive promoter element (CRE)-binding factors since it is inducible by activation of the cAMP signaling pathway. The kinetic of expression is characteristic of an early response gene. The induction is transient and cell specific, does not involve increased transcript stability, and does not require protein synthesis. Significantly, the subsequent decline in CREM expression requires de novo protein synthesis. The induced transcript encodes a novel repressor, inducible cAMP early repressor (ICER), and is generated from an alternative intronic promoter. A cluster of four CREs in this promoter directs cAMP inducibility. ICER binds to these elements and thereby represses the activity of its own promoter, thus constituting a negative autoregulatory loop.</abstract><cop>Cambridge, MA</cop><pub>Elsevier Inc</pub><pmid>8252624</pmid><doi>10.1016/0092-8674(93)90532-U</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenylyl Cyclases - physiology Alternative Splicing Amino Acid Sequence Animals Base Sequence Biological and medical sciences Cloning, Molecular Cyclic AMP - physiology Cyclic AMP Response Element Modulator DNA-Binding Proteins - genetics Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation Introns Male Molecular and cellular biology Molecular genetics Molecular Sequence Data Nuclear Proteins - genetics Promoter Regions, Genetic Rats Rats, Wistar Receptors, Cyclic AMP - physiology Repressor Proteins - genetics RNA, Messenger - genetics Signal Transduction Time Factors |
| title | Inducibility and negative autoregulation of CREM: An alternative promoter directs the expression of ICER, an early response repressor |
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