Cyclic AMP-dependent protein kinase in Molt 4b lymphoblasts: identification by photoaffinity labeling and activation in intact cells by vasoactive intestinal polypeptide (VIP) and peptide histidine isoleucine (PHI)

Molt 4b lymphoblasts have previously been shown to possess a single class of pharmacologically specific, high affinity receptors for vasoactive intestinal polypeptide (VIP). This study further explores the molecular basis for modulation of human lymphocyte function by VIP. Dose-dependent stimulation...

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Veröffentlicht in:	The Journal of immunology (1950) 1985-06, Vol.134 (6), p.4078-4086
Hauptverfasser:	O'Dorisio, MS, Wood, CL, Wenger, GD, Vassalo, LM
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - metabolism Affinity Labels Analysis of the immune response. Humoral and cellular immunity Biological and medical sciences Cell Extracts - metabolism Cell interactions Cell Line Colforsin Cyclic AMP - metabolism Diterpenes - pharmacology Enzyme Activation Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Lymphocytes - enzymology Lymphocytes - metabolism Peptide PHI Peptides - pharmacology Phosphorylation Protein Kinases - metabolism Vasoactive Intestinal Peptide - pharmacology
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