Role of LFA‐1/ICAM‐1 in interleukin‐2‐stimulated lymphocyte proliferation

Major adhesion routes between lymphoid cells involve the receptor/ligand pairs LFA‐l/ICAM‐1 and CD2/LFA‐3, in addition to VLA or CD44 molecules. In this study we evaluated the role of these adhesion receptors in the proliferative response of lymphoid cells to interleukin‐2 (IL‐2). Blocking studies w...

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Veröffentlicht in:	European journal of immunology 1993-12, Vol.23 (12), p.3292-3299
Hauptverfasser:	Vyth‐Dreese, Florry A., Dellemijn, Trees A. M., Frijhoff, Anita, van Kooyk, Yvette, Figdor, Carl G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Antibodies, Monoclonal - immunology Biological and medical sciences Cell Adhesion Molecules - physiology Cells, Cultured Fundamental and applied biological sciences. Psychology Fundamental immunology Humans ICAM‐1 Immunobiology Intercellular Adhesion Molecule-1 Interleukin-2 - pharmacology Interleukin‐2 Interleukin‐2 receptor Killer Cells, Natural - drug effects LFA‐1 Lymphocyte Activation - drug effects Lymphocyte Function-Associated Antigen-1 - physiology Lymphokines, interleukins ( function, expression) Proliferation Receptors, Interleukin-2 - physiology Recombinant Proteins - pharmacology Regulatory factors and their cellular receptors T-Lymphocytes - drug effects T-Lymphocytes - immunology
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