Randomized trial comparing cryopreserved cultured epidermal allografts with hydrocolloid dressings in healing chronic venous ulcers
Background : Cultured epidermal allografts have been successfully used to treat a variety of wounds. Their postulated mechanism of action is through release of cytokines that stimulate epithelialization. On the basis of previous experience we expected ulcers treated with cryopreserved cultured allog...
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| Veröffentlicht in: | Journal of the American Academy of Dermatology 1993-12, Vol.29 (6), p.982-988 |
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| container_title | Journal of the American Academy of Dermatology |
| container_volume | 29 |
| creator | Teepe, Robert G.C. Roseeuw, Diane I. Hermans, Jo Koebrugge, Eline J. Altena, Theo Coninck, Arlette de Ponec, Maria Vermeer, Bert Jan |
| description | Background
: Cultured epidermal allografts have been successfully used to treat a variety of wounds. Their postulated mechanism of action is through release of cytokines that stimulate epithelialization. On the basis of previous experience we expected ulcers treated with cryopreserved cultured allografts (CCAs) to be healed by 6 weeks. Hydrocolloid dressings (HCDs) have also been reported to be effective in the treatment of venous ulcers.
Objective
: Our purpose was to compare the effectiveness of CCAs with HCDs in healing chronic venous ulcers.
Methods
: Forty-three patients with 47 ulcers were enrolled in a randomized controlled trial. Ulcers not healed by 6 weeks were changed to the other treatment.
Results
: No difference in the number of healed ulcers between the two groups was observed at 6 weeks. Healing rate, percent reduction of initial ulcer size, and radial progression toward wound closure were significantly greater for CCAs than for HCDs. Pain relief was not significantly different.
Conclusion
: CCAs achieve more rapid healing and greater reduction in ulcer size than HCDs. |
| doi_str_mv | 10.1016/0190-9622(93)70278-2 |
| format | Article |
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: Cultured epidermal allografts have been successfully used to treat a variety of wounds. Their postulated mechanism of action is through release of cytokines that stimulate epithelialization. On the basis of previous experience we expected ulcers treated with cryopreserved cultured allografts (CCAs) to be healed by 6 weeks. Hydrocolloid dressings (HCDs) have also been reported to be effective in the treatment of venous ulcers.
Objective
: Our purpose was to compare the effectiveness of CCAs with HCDs in healing chronic venous ulcers.
Methods
: Forty-three patients with 47 ulcers were enrolled in a randomized controlled trial. Ulcers not healed by 6 weeks were changed to the other treatment.
Results
: No difference in the number of healed ulcers between the two groups was observed at 6 weeks. Healing rate, percent reduction of initial ulcer size, and radial progression toward wound closure were significantly greater for CCAs than for HCDs. Pain relief was not significantly different.
Conclusion
: CCAs achieve more rapid healing and greater reduction in ulcer size than HCDs.</description><identifier>ISSN: 0190-9622</identifier><identifier>EISSN: 1097-6787</identifier><identifier>DOI: 10.1016/0190-9622(93)70278-2</identifier><identifier>PMID: 8245265</identifier><identifier>CODEN: JAADDB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biological Dressings ; Chronic Disease ; Colloids ; Cryopreservation ; Culture Techniques ; Epidermis - transplantation ; Female ; Follow-Up Studies ; Humans ; Male ; Medical sciences ; Middle Aged ; Pain - epidemiology ; Patient Dropouts - statistics & numerical data ; Pharmacology. Drug treatments ; Skin plastic surgery ; Skin, nail, hair, dermoskeleton ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Time Factors ; Treatment Outcome ; Varicose Ulcer - therapy ; Wound Healing - physiology</subject><ispartof>Journal of the American Academy of Dermatology, 1993-12, Vol.29 (6), p.982-988</ispartof><rights>1993 American Academy of Dermatology, Inc.</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-cdf2d0be78544047f4df3e58bb5ad738dcbcc5e99348eb094c4638832023e90e3</citedby><cites>FETCH-LOGICAL-c386t-cdf2d0be78544047f4df3e58bb5ad738dcbcc5e99348eb094c4638832023e90e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0190-9622(93)70278-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3798938$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8245265$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Teepe, Robert G.C.</creatorcontrib><creatorcontrib>Roseeuw, Diane I.</creatorcontrib><creatorcontrib>Hermans, Jo</creatorcontrib><creatorcontrib>Koebrugge, Eline J.</creatorcontrib><creatorcontrib>Altena, Theo</creatorcontrib><creatorcontrib>Coninck, Arlette de</creatorcontrib><creatorcontrib>Ponec, Maria</creatorcontrib><creatorcontrib>Vermeer, Bert Jan</creatorcontrib><title>Randomized trial comparing cryopreserved cultured epidermal allografts with hydrocolloid dressings in healing chronic venous ulcers</title><title>Journal of the American Academy of Dermatology</title><addtitle>J Am Acad Dermatol</addtitle><description>Background
: Cultured epidermal allografts have been successfully used to treat a variety of wounds. Their postulated mechanism of action is through release of cytokines that stimulate epithelialization. On the basis of previous experience we expected ulcers treated with cryopreserved cultured allografts (CCAs) to be healed by 6 weeks. Hydrocolloid dressings (HCDs) have also been reported to be effective in the treatment of venous ulcers.
Objective
: Our purpose was to compare the effectiveness of CCAs with HCDs in healing chronic venous ulcers.
Methods
: Forty-three patients with 47 ulcers were enrolled in a randomized controlled trial. Ulcers not healed by 6 weeks were changed to the other treatment.
Results
: No difference in the number of healed ulcers between the two groups was observed at 6 weeks. Healing rate, percent reduction of initial ulcer size, and radial progression toward wound closure were significantly greater for CCAs than for HCDs. Pain relief was not significantly different.
Conclusion
: CCAs achieve more rapid healing and greater reduction in ulcer size than HCDs.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biological Dressings</subject><subject>Chronic Disease</subject><subject>Colloids</subject><subject>Cryopreservation</subject><subject>Culture Techniques</subject><subject>Epidermis - transplantation</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pain - epidemiology</subject><subject>Patient Dropouts - statistics & numerical data</subject><subject>Pharmacology. Drug treatments</subject><subject>Skin plastic surgery</subject><subject>Skin, nail, hair, dermoskeleton</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Varicose Ulcer - therapy</subject><subject>Wound Healing - physiology</subject><issn>0190-9622</issn><issn>1097-6787</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF2L1DAUhoMo6-zqP1DIhch6UU2TtEluFmTxCxYE0euQJqc7kbapJ-3IeOsfN7MzzKVXCXmf83LyEPKiZm9rVrfvWG1YZVrOr414oxhXuuKPyKZmRlWt0uox2ZyRp-Qy55-MMSOFuiAXmsuGt82G_P3mppDG-AcCXTC6gfo0zg7jdE897tOMkAF3JfXrsKxYLjDHADgW1A1DukfXL5n-jsuWbvcBk0_lNQYaymQuNZnGiW7BDQ-VW0xT9HQHU1ozXQcPmJ-RJ70bMjw_nVfkx8cP328_V3dfP325fX9XeaHbpfKh54F1oHQjJZOql6EX0Oiua1xQQgffed-AMUJq6MpPvWyF1oIzLsAwEFfk9bF3xvRrhbzYMWYPw-AmKNtY1TIthJIFlEfQY8oZobczxtHh3tbMHtzbg1h7EGuNsA_uLS9jL0_9azdCOA-dZJf81Sl32buhRzf5mM-YUEYboQt2c8SguNhFQJt9hMlDiAh-sSHF_-_xD5pkpBs</recordid><startdate>19931201</startdate><enddate>19931201</enddate><creator>Teepe, Robert G.C.</creator><creator>Roseeuw, Diane I.</creator><creator>Hermans, Jo</creator><creator>Koebrugge, Eline J.</creator><creator>Altena, Theo</creator><creator>Coninck, Arlette de</creator><creator>Ponec, Maria</creator><creator>Vermeer, Bert Jan</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19931201</creationdate><title>Randomized trial comparing cryopreserved cultured epidermal allografts with hydrocolloid dressings in healing chronic venous ulcers</title><author>Teepe, Robert G.C. ; Roseeuw, Diane I. ; Hermans, Jo ; Koebrugge, Eline J. ; Altena, Theo ; Coninck, Arlette de ; Ponec, Maria ; Vermeer, Bert Jan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-cdf2d0be78544047f4df3e58bb5ad738dcbcc5e99348eb094c4638832023e90e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biological Dressings</topic><topic>Chronic Disease</topic><topic>Colloids</topic><topic>Cryopreservation</topic><topic>Culture Techniques</topic><topic>Epidermis - transplantation</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pain - epidemiology</topic><topic>Patient Dropouts - statistics & numerical data</topic><topic>Pharmacology. Drug treatments</topic><topic>Skin plastic surgery</topic><topic>Skin, nail, hair, dermoskeleton</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Varicose Ulcer - therapy</topic><topic>Wound Healing - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Teepe, Robert G.C.</creatorcontrib><creatorcontrib>Roseeuw, Diane I.</creatorcontrib><creatorcontrib>Hermans, Jo</creatorcontrib><creatorcontrib>Koebrugge, Eline J.</creatorcontrib><creatorcontrib>Altena, Theo</creatorcontrib><creatorcontrib>Coninck, Arlette de</creatorcontrib><creatorcontrib>Ponec, Maria</creatorcontrib><creatorcontrib>Vermeer, Bert Jan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Academy of Dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Teepe, Robert G.C.</au><au>Roseeuw, Diane I.</au><au>Hermans, Jo</au><au>Koebrugge, Eline J.</au><au>Altena, Theo</au><au>Coninck, Arlette de</au><au>Ponec, Maria</au><au>Vermeer, Bert Jan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Randomized trial comparing cryopreserved cultured epidermal allografts with hydrocolloid dressings in healing chronic venous ulcers</atitle><jtitle>Journal of the American Academy of Dermatology</jtitle><addtitle>J Am Acad Dermatol</addtitle><date>1993-12-01</date><risdate>1993</risdate><volume>29</volume><issue>6</issue><spage>982</spage><epage>988</epage><pages>982-988</pages><issn>0190-9622</issn><eissn>1097-6787</eissn><coden>JAADDB</coden><abstract>Background
: Cultured epidermal allografts have been successfully used to treat a variety of wounds. Their postulated mechanism of action is through release of cytokines that stimulate epithelialization. On the basis of previous experience we expected ulcers treated with cryopreserved cultured allografts (CCAs) to be healed by 6 weeks. Hydrocolloid dressings (HCDs) have also been reported to be effective in the treatment of venous ulcers.
Objective
: Our purpose was to compare the effectiveness of CCAs with HCDs in healing chronic venous ulcers.
Methods
: Forty-three patients with 47 ulcers were enrolled in a randomized controlled trial. Ulcers not healed by 6 weeks were changed to the other treatment.
Results
: No difference in the number of healed ulcers between the two groups was observed at 6 weeks. Healing rate, percent reduction of initial ulcer size, and radial progression toward wound closure were significantly greater for CCAs than for HCDs. Pain relief was not significantly different.
Conclusion
: CCAs achieve more rapid healing and greater reduction in ulcer size than HCDs.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>8245265</pmid><doi>10.1016/0190-9622(93)70278-2</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0190-9622 |
| ispartof | Journal of the American Academy of Dermatology, 1993-12, Vol.29 (6), p.982-988 |
| issn | 0190-9622 1097-6787 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76083374 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Biological Dressings Chronic Disease Colloids Cryopreservation Culture Techniques Epidermis - transplantation Female Follow-Up Studies Humans Male Medical sciences Middle Aged Pain - epidemiology Patient Dropouts - statistics & numerical data Pharmacology. Drug treatments Skin plastic surgery Skin, nail, hair, dermoskeleton Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Time Factors Treatment Outcome Varicose Ulcer - therapy Wound Healing - physiology |
| title | Randomized trial comparing cryopreserved cultured epidermal allografts with hydrocolloid dressings in healing chronic venous ulcers |
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