The Effect of Dietary Protein Quality and Feeding Level on Milk Secretion and Mammary Protein Synthesis in the Rat
Protein synthesis was studied in mammary tissue of rats fed diets deficient in protein quality and/or restricted in food intake throughout gestation and lactation. Diets containing 25% wheat gluten (WG), wheat gluten plus lysine and threonine (WGLT), or casein (C) were pair-fed from conception until...
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| Veröffentlicht in: | J. Pediatr. Gastroenterol. Nutr.; (United States) 1985-04, Vol.4 (2), p.274-283 |
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| creator | Sampson, David A Jansen, G Richard |
| description | Protein synthesis was studied in mammary tissue of rats fed diets deficient in protein quality and/or restricted in food intake throughout gestation and lactation. Diets containing 25% wheat gluten (WG), wheat gluten plus lysine and threonine (WGLT), or casein (C) were pair-fed from conception until day 15 of lactation at 100% or 85% of WG ad libitum consumption (PF100 and PF85, respectively). A seventh group was fed C ad libitum. Rates of protein synthesis were measured in vivo at day 15 of lactation from incorporation of [3-H]phenylalanine. At both PF100 and PF85, fractional and absolute rates of mammary gland protein synthesis were two- to three-fold higher in rats fed C than in those fed WG. Pup weights showed similar treatment effects. Both mammary protein synthesis rates and pup weights were significantly higher in rats fed C at PF85 than rats fed WG ad libitum. Food restriction from PF100 to PF85 depressed pup weights and mammary protein synthesis rates in rats fed WGLT, but had no effect in rats fed WG. These results demonstrate that when food intake is restricted, improvement of protein quality of the maternal diet increases milk output in the rat in association with increased rates of mammary protein synthesis. |
| doi_str_mv | 10.1097/00005176-198504000-00020 |
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Diets containing 25% wheat gluten (WG), wheat gluten plus lysine and threonine (WGLT), or casein (C) were pair-fed from conception until day 15 of lactation at 100% or 85% of WG ad libitum consumption (PF100 and PF85, respectively). A seventh group was fed C ad libitum. Rates of protein synthesis were measured in vivo at day 15 of lactation from incorporation of [3-H]phenylalanine. At both PF100 and PF85, fractional and absolute rates of mammary gland protein synthesis were two- to three-fold higher in rats fed C than in those fed WG. Pup weights showed similar treatment effects. Both mammary protein synthesis rates and pup weights were significantly higher in rats fed C at PF85 than rats fed WG ad libitum. Food restriction from PF100 to PF85 depressed pup weights and mammary protein synthesis rates in rats fed WGLT, but had no effect in rats fed WG. These results demonstrate that when food intake is restricted, improvement of protein quality of the maternal diet increases milk output in the rat in association with increased rates of mammary protein synthesis.</description><identifier>ISSN: 0277-2116</identifier><identifier>EISSN: 1536-4801</identifier><identifier>DOI: 10.1097/00005176-198504000-00020</identifier><identifier>PMID: 2580963</identifier><identifier>CODEN: JPGND6</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>551001 - Physiological Systems- Tracer Techniques ; AMINO ACIDS ; ANIMALS ; BASIC BIOLOGICAL SCIENCES ; Biological and medical sciences ; BIOLOGICAL EFFECTS ; BIOLOGICAL MATERIALS ; BIOSYNTHESIS ; BODY ; BODY FLUIDS ; CARBOXYLIC ACIDS ; DIET ; Dietary Proteins - administration & dosage ; Dietary Proteins - pharmacology ; DNA ; DNA - biosynthesis ; Female ; FOOD ; Food Deprivation ; Fundamental and applied biological sciences. Psychology ; GLANDS ; LABELLED COMPOUNDS ; LACTATION ; MAMMALS ; MAMMARY GLANDS ; Mammary Glands, Animal - metabolism ; MATERIALS ; MILK ; Milk - metabolism ; Mother. Fetoplacental unit. Mammary gland. Milk ; NUCLEIC ACIDS ; ORGANIC ACIDS ; ORGANIC COMPOUNDS ; ORGANS ; PHENYLALANINE ; PREGNANCY ; Pregnancy. Parturition. Lactation ; Protein Biosynthesis ; PROTEINS ; RATS ; RNA ; RNA - biosynthesis ; RODENTS ; SYNTHESIS ; Tritium ; TRITIUM COMPOUNDS ; VERTEBRATES ; Vertebrates: reproduction</subject><ispartof>J. Pediatr. Gastroenterol. Nutr.; (United States), 1985-04, Vol.4 (2), p.274-283</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4610-2948865a62e26222f28ed14621d3b1a52fd168790255256da7d1c20ea8bdf92e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8489775$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2580963$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/5125351$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Sampson, David A</creatorcontrib><creatorcontrib>Jansen, G Richard</creatorcontrib><creatorcontrib>Colorado State Univ., Fort Collins</creatorcontrib><title>The Effect of Dietary Protein Quality and Feeding Level on Milk Secretion and Mammary Protein Synthesis in the Rat</title><title>J. Pediatr. Gastroenterol. Nutr.; (United States)</title><addtitle>J Pediatr Gastroenterol Nutr</addtitle><description>Protein synthesis was studied in mammary tissue of rats fed diets deficient in protein quality and/or restricted in food intake throughout gestation and lactation. Diets containing 25% wheat gluten (WG), wheat gluten plus lysine and threonine (WGLT), or casein (C) were pair-fed from conception until day 15 of lactation at 100% or 85% of WG ad libitum consumption (PF100 and PF85, respectively). A seventh group was fed C ad libitum. Rates of protein synthesis were measured in vivo at day 15 of lactation from incorporation of [3-H]phenylalanine. At both PF100 and PF85, fractional and absolute rates of mammary gland protein synthesis were two- to three-fold higher in rats fed C than in those fed WG. Pup weights showed similar treatment effects. Both mammary protein synthesis rates and pup weights were significantly higher in rats fed C at PF85 than rats fed WG ad libitum. Food restriction from PF100 to PF85 depressed pup weights and mammary protein synthesis rates in rats fed WGLT, but had no effect in rats fed WG. These results demonstrate that when food intake is restricted, improvement of protein quality of the maternal diet increases milk output in the rat in association with increased rates of mammary protein synthesis.</description><subject>551001 - Physiological Systems- Tracer Techniques</subject><subject>AMINO ACIDS</subject><subject>ANIMALS</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BIOLOGICAL MATERIALS</subject><subject>BIOSYNTHESIS</subject><subject>BODY</subject><subject>BODY FLUIDS</subject><subject>CARBOXYLIC ACIDS</subject><subject>DIET</subject><subject>Dietary Proteins - administration & dosage</subject><subject>Dietary Proteins - pharmacology</subject><subject>DNA</subject><subject>DNA - biosynthesis</subject><subject>Female</subject><subject>FOOD</subject><subject>Food Deprivation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GLANDS</subject><subject>LABELLED COMPOUNDS</subject><subject>LACTATION</subject><subject>MAMMALS</subject><subject>MAMMARY GLANDS</subject><subject>Mammary Glands, Animal - metabolism</subject><subject>MATERIALS</subject><subject>MILK</subject><subject>Milk - metabolism</subject><subject>Mother. Fetoplacental unit. Mammary gland. Milk</subject><subject>NUCLEIC ACIDS</subject><subject>ORGANIC ACIDS</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANS</subject><subject>PHENYLALANINE</subject><subject>PREGNANCY</subject><subject>Pregnancy. Parturition. Lactation</subject><subject>Protein Biosynthesis</subject><subject>PROTEINS</subject><subject>RATS</subject><subject>RNA</subject><subject>RNA - biosynthesis</subject><subject>RODENTS</subject><subject>SYNTHESIS</subject><subject>Tritium</subject><subject>TRITIUM COMPOUNDS</subject><subject>VERTEBRATES</subject><subject>Vertebrates: reproduction</subject><issn>0277-2116</issn><issn>1536-4801</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kl9vFCEUxYnR1LX6EUyIMX0bBWb4M4-mtrbJNra2PhMWLg6WnanAtNlvL-uuG18kIXByf-eSmwNCmJIPlPTyI6mLUyka2itOuqqauhl5hhaUt6LpFKHP0YIwKRtGqXiJXuX8syKy4-QIHTGuSC_aBUp3A-Az78EWPHn8OUAxaYOv01QgjPhmNjGUDTajw-cALow_8BIeIeJpxFch3uNbsAlKqHLLXJn1-l__7WYsA-SQcRX1hr-Z8hq98CZmeLM_j9H387O704tm-fXL5emnZWM7QUnD-k4pwY1gwARjzDMFjnaCUdeuqOHMOyqU7AnjnHHhjHTUMgJGrZzvGbTH6N2u75RL0NmGAnaw0zjWWTWnjLecVuhkBz2k6dcMueh1yBZiNCNMc9ZSEEUlFxVUO9CmKecEXj-ksJ1VU6K3mei_mehDJvpPJtX6dv_GvFqDOxj3IdT6-33dZGuiT2a0IR8w1aleSl6xboc9TbFAyvdxfoKkBzCxDPp_P6L9DV14oWM</recordid><startdate>198504</startdate><enddate>198504</enddate><creator>Sampson, David A</creator><creator>Jansen, G Richard</creator><general>Lippincott-Raven Publishers</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>198504</creationdate><title>The Effect of Dietary Protein Quality and Feeding Level on Milk Secretion and Mammary Protein Synthesis in the Rat</title><author>Sampson, David A ; Jansen, G Richard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4610-2948865a62e26222f28ed14621d3b1a52fd168790255256da7d1c20ea8bdf92e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>551001 - Physiological Systems- Tracer Techniques</topic><topic>AMINO ACIDS</topic><topic>ANIMALS</topic><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL EFFECTS</topic><topic>BIOLOGICAL MATERIALS</topic><topic>BIOSYNTHESIS</topic><topic>BODY</topic><topic>BODY FLUIDS</topic><topic>CARBOXYLIC ACIDS</topic><topic>DIET</topic><topic>Dietary Proteins - administration & dosage</topic><topic>Dietary Proteins - pharmacology</topic><topic>DNA</topic><topic>DNA - biosynthesis</topic><topic>Female</topic><topic>FOOD</topic><topic>Food Deprivation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GLANDS</topic><topic>LABELLED COMPOUNDS</topic><topic>LACTATION</topic><topic>MAMMALS</topic><topic>MAMMARY GLANDS</topic><topic>Mammary Glands, Animal - metabolism</topic><topic>MATERIALS</topic><topic>MILK</topic><topic>Milk - metabolism</topic><topic>Mother. Fetoplacental unit. Mammary gland. Milk</topic><topic>NUCLEIC ACIDS</topic><topic>ORGANIC ACIDS</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANS</topic><topic>PHENYLALANINE</topic><topic>PREGNANCY</topic><topic>Pregnancy. Parturition. Lactation</topic><topic>Protein Biosynthesis</topic><topic>PROTEINS</topic><topic>RATS</topic><topic>RNA</topic><topic>RNA - biosynthesis</topic><topic>RODENTS</topic><topic>SYNTHESIS</topic><topic>Tritium</topic><topic>TRITIUM COMPOUNDS</topic><topic>VERTEBRATES</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sampson, David A</creatorcontrib><creatorcontrib>Jansen, G Richard</creatorcontrib><creatorcontrib>Colorado State Univ., Fort Collins</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>J. Pediatr. Gastroenterol. Nutr.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sampson, David A</au><au>Jansen, G Richard</au><aucorp>Colorado State Univ., Fort Collins</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of Dietary Protein Quality and Feeding Level on Milk Secretion and Mammary Protein Synthesis in the Rat</atitle><jtitle>J. Pediatr. Gastroenterol. Nutr.; (United States)</jtitle><addtitle>J Pediatr Gastroenterol Nutr</addtitle><date>1985-04</date><risdate>1985</risdate><volume>4</volume><issue>2</issue><spage>274</spage><epage>283</epage><pages>274-283</pages><issn>0277-2116</issn><eissn>1536-4801</eissn><coden>JPGND6</coden><abstract>Protein synthesis was studied in mammary tissue of rats fed diets deficient in protein quality and/or restricted in food intake throughout gestation and lactation. Diets containing 25% wheat gluten (WG), wheat gluten plus lysine and threonine (WGLT), or casein (C) were pair-fed from conception until day 15 of lactation at 100% or 85% of WG ad libitum consumption (PF100 and PF85, respectively). A seventh group was fed C ad libitum. Rates of protein synthesis were measured in vivo at day 15 of lactation from incorporation of [3-H]phenylalanine. At both PF100 and PF85, fractional and absolute rates of mammary gland protein synthesis were two- to three-fold higher in rats fed C than in those fed WG. Pup weights showed similar treatment effects. Both mammary protein synthesis rates and pup weights were significantly higher in rats fed C at PF85 than rats fed WG ad libitum. Food restriction from PF100 to PF85 depressed pup weights and mammary protein synthesis rates in rats fed WGLT, but had no effect in rats fed WG. These results demonstrate that when food intake is restricted, improvement of protein quality of the maternal diet increases milk output in the rat in association with increased rates of mammary protein synthesis.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>2580963</pmid><doi>10.1097/00005176-198504000-00020</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0277-2116 |
| ispartof | J. Pediatr. Gastroenterol. Nutr.; (United States), 1985-04, Vol.4 (2), p.274-283 |
| issn | 0277-2116 1536-4801 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | 551001 - Physiological Systems- Tracer Techniques AMINO ACIDS ANIMALS BASIC BIOLOGICAL SCIENCES Biological and medical sciences BIOLOGICAL EFFECTS BIOLOGICAL MATERIALS BIOSYNTHESIS BODY BODY FLUIDS CARBOXYLIC ACIDS DIET Dietary Proteins - administration & dosage Dietary Proteins - pharmacology DNA DNA - biosynthesis Female FOOD Food Deprivation Fundamental and applied biological sciences. Psychology GLANDS LABELLED COMPOUNDS LACTATION MAMMALS MAMMARY GLANDS Mammary Glands, Animal - metabolism MATERIALS MILK Milk - metabolism Mother. Fetoplacental unit. Mammary gland. Milk NUCLEIC ACIDS ORGANIC ACIDS ORGANIC COMPOUNDS ORGANS PHENYLALANINE PREGNANCY Pregnancy. Parturition. Lactation Protein Biosynthesis PROTEINS RATS RNA RNA - biosynthesis RODENTS SYNTHESIS Tritium TRITIUM COMPOUNDS VERTEBRATES Vertebrates: reproduction |
| title | The Effect of Dietary Protein Quality and Feeding Level on Milk Secretion and Mammary Protein Synthesis in the Rat |
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