Pharmacokinetics of remifentanil (GI87084B) and its major metabolite (GI90291) in patients undergoing elective inpatient surgery

Remifentanil is a highly potent opioid with a rapid onset and a short duration of action due to its rapid hydrolysis by esterases in blood and tissues. The major metabolite of remifentanil, GI90291, is much less potent than remifentanil. The pharmacokinetics of remifentanil and its major metabolite,...

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Veröffentlicht in:	Anesthesiology (Philadelphia) 1993-11, Vol.79 (5), p.893-903
Hauptverfasser:	WESTMORELAND, C. L, HOKE, J. F, SEBEL, P. S, HUG, C. C, MUIR, K. T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Analgesics Analgesics, Opioid - administration & dosage Analgesics, Opioid - blood Analgesics, Opioid - pharmacokinetics Biological and medical sciences Elective Surgical Procedures Female Humans Infusions, Intravenous Male Medical sciences Middle Aged Neuropharmacology Pharmacology. Drug treatments Piperidines - administration & dosage Piperidines - blood Piperidines - pharmacokinetics Remifentanil Time Factors
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