Determination of midazolam and its α-hydroxy metabolite in human plasma and urine by high-performance liquid chromatography

We describe a new high-performance liquid chromatography (HPLC) method for measurement of midazolam and its major metabolite, alpha-hydroxymidazolam, in clinical samples. Plasma or urine was mixed with 100 ng internal standard Ro 05-6669 and borate buffer, 0.1 M, pH 9. Midazolam and its related comp...

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Veröffentlicht in:	Therapeutic drug monitoring 1993-08, Vol.15 (4), p.338-343
Hauptverfasser:	HUY RIEM HA, RENTSCH, K. M, KNEER, J, VONDERSCHMITT, D. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Benzodiazepinones - analysis Biological and medical sciences Chromatography, High Pressure Liquid - methods General pharmacology Humans Medical sciences Midazolam - analogs & derivatives Midazolam - analysis Midazolam - blood Midazolam - urine Pharmacology. Drug treatments Spectrophotometry, Ultraviolet
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