Effects of transluminal coronary angioplasty on left ventricular systolic and diastolic function at rest and during exercise
The left ventricular global and regional systolic function, ventricular volumes, and peak diastolic filling rate (PDFR) were studied in 30 patients with coronary artery disease, before and 2 to 5 days after transluminal coronary angioplasty (PTCA), utilizing equilibrium radionuclide angiography at r...
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| Veröffentlicht in: | The American heart journal 1985, Vol.109 (4), p.792-798 |
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| creator | Lewis, Jannet F. Verani, Mario S. Poliner, Lawrence R. Lewis, John M. Raizner, Albert E. |
| description | The left ventricular global and regional systolic function, ventricular volumes, and peak diastolic filling rate (PDFR) were studied in 30 patients with coronary artery disease, before and 2 to 5 days after transluminal coronary angioplasty (PTCA), utilizing equilibrium radionuclide angiography at rest and during exercise. At rest, the global ejection fraction (EF) was unchanged before (60 ± 9%) and after PTCA (62 ± 10%). During exercise, global EF increased from 59 ± 11% pre PTCA to 67 ± 10 post PTCA (
p < 0.001). Twenty-two patients had abnormal EF response to exercise pre PTCA, versus seven post PTCA (
p < 0.001). Improvements in exercise regional EF paralleled the changes in global EF. End-systolic volume was unchanged at rest but decreased significantly with exercise post PTCA (60 ± 36 ml pre vs 49 ± 32 ml post PTCA,
p < 0.01). At rest, the PDFR was unchanged post PTCA (2.4 ± 0.9 end-diastolic volume (EDV)/sec pre vs 2.5 ± 0.8 EDV/sec post). During exercise, PDFR increased from 2.1 ± 0.7 EDV/sec pre PTCA to 2.5 ± 0.7 EDV/sec post PTCA (
p < 0.02). In conclusion, in patients with coronary artery disease, successful PTCA improves global and regional systolic function during exercise. Diastolic function is improved during exercise, a fact not previously demonstrated. |
| doi_str_mv | 10.1016/0002-8703(85)90640-4 |
| format | Article |
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p < 0.001). Twenty-two patients had abnormal EF response to exercise pre PTCA, versus seven post PTCA (
p < 0.001). Improvements in exercise regional EF paralleled the changes in global EF. End-systolic volume was unchanged at rest but decreased significantly with exercise post PTCA (60 ± 36 ml pre vs 49 ± 32 ml post PTCA,
p < 0.01). At rest, the PDFR was unchanged post PTCA (2.4 ± 0.9 end-diastolic volume (EDV)/sec pre vs 2.5 ± 0.8 EDV/sec post). During exercise, PDFR increased from 2.1 ± 0.7 EDV/sec pre PTCA to 2.5 ± 0.7 EDV/sec post PTCA (
p < 0.02). In conclusion, in patients with coronary artery disease, successful PTCA improves global and regional systolic function during exercise. Diastolic function is improved during exercise, a fact not previously demonstrated.</description><identifier>ISSN: 0002-8703</identifier><identifier>EISSN: 1097-6744</identifier><identifier>DOI: 10.1016/0002-8703(85)90640-4</identifier><identifier>PMID: 3157303</identifier><identifier>CODEN: AHJOA2</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Aged ; Angioplasty, Balloon ; Biological and medical sciences ; Cardiac Output ; Cardiology. Vascular system ; Coronary Disease - diagnostic imaging ; Coronary Disease - physiopathology ; Coronary Disease - therapy ; Coronary heart disease ; Coronary Vessels - diagnostic imaging ; Diastole ; Exercise Test ; Female ; Heart ; Humans ; Male ; Medical sciences ; Middle Aged ; Radionuclide Imaging ; Stroke Volume ; Systole</subject><ispartof>The American heart journal, 1985, Vol.109 (4), p.792-798</ispartof><rights>1985</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-3ce234905d283b9089e30203bf023ff13cde1384198e27d2d2ec0bcd904327f23</citedby><cites>FETCH-LOGICAL-c396t-3ce234905d283b9089e30203bf023ff13cde1384198e27d2d2ec0bcd904327f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0002870385906404$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9082827$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3157303$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lewis, Jannet F.</creatorcontrib><creatorcontrib>Verani, Mario S.</creatorcontrib><creatorcontrib>Poliner, Lawrence R.</creatorcontrib><creatorcontrib>Lewis, John M.</creatorcontrib><creatorcontrib>Raizner, Albert E.</creatorcontrib><title>Effects of transluminal coronary angioplasty on left ventricular systolic and diastolic function at rest and during exercise</title><title>The American heart journal</title><addtitle>Am Heart J</addtitle><description>The left ventricular global and regional systolic function, ventricular volumes, and peak diastolic filling rate (PDFR) were studied in 30 patients with coronary artery disease, before and 2 to 5 days after transluminal coronary angioplasty (PTCA), utilizing equilibrium radionuclide angiography at rest and during exercise. At rest, the global ejection fraction (EF) was unchanged before (60 ± 9%) and after PTCA (62 ± 10%). During exercise, global EF increased from 59 ± 11% pre PTCA to 67 ± 10 post PTCA (
p < 0.001). Twenty-two patients had abnormal EF response to exercise pre PTCA, versus seven post PTCA (
p < 0.001). Improvements in exercise regional EF paralleled the changes in global EF. End-systolic volume was unchanged at rest but decreased significantly with exercise post PTCA (60 ± 36 ml pre vs 49 ± 32 ml post PTCA,
p < 0.01). At rest, the PDFR was unchanged post PTCA (2.4 ± 0.9 end-diastolic volume (EDV)/sec pre vs 2.5 ± 0.8 EDV/sec post). During exercise, PDFR increased from 2.1 ± 0.7 EDV/sec pre PTCA to 2.5 ± 0.7 EDV/sec post PTCA (
p < 0.02). In conclusion, in patients with coronary artery disease, successful PTCA improves global and regional systolic function during exercise. Diastolic function is improved during exercise, a fact not previously demonstrated.</description><subject>Adult</subject><subject>Aged</subject><subject>Angioplasty, Balloon</subject><subject>Biological and medical sciences</subject><subject>Cardiac Output</subject><subject>Cardiology. Vascular system</subject><subject>Coronary Disease - diagnostic imaging</subject><subject>Coronary Disease - physiopathology</subject><subject>Coronary Disease - therapy</subject><subject>Coronary heart disease</subject><subject>Coronary Vessels - diagnostic imaging</subject><subject>Diastole</subject><subject>Exercise Test</subject><subject>Female</subject><subject>Heart</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Radionuclide Imaging</subject><subject>Stroke Volume</subject><subject>Systole</subject><issn>0002-8703</issn><issn>1097-6744</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2LFDEQhoMo6-zqP1DIQWQ9tFYn6e70ZUGW9QMWvOg5ZJLKEskkY5JeHPDHm3GaOXoKRT1vUfWEkFc9vO-hHz8AAOvkBPxaDu9mGAV04gnZ9DBP3TgJ8ZRszshzclnKz1aOTI4X5IL3w8SBb8ifO-fQ1EKTozXrWMKy81EHalJOUecD1fHBp33QpR5oijSgq_QRY83eLEFnWg6lpuBNAy21Xq-VW6KpvgV0pRlLPbWX7OMDxd-YjS_4gjxzOhR8ub5X5Menu--3X7r7b5-_3n687wyfx9pxg4yLGQbLJN_OIGfkwIBvHTDuXM-NxZ5L0c8S2WSZZWhga-wMgrPJMX5F3p7m7nP6tbRl1M4XgyHoiGkpahphksM4NFCcQJNTKRmd2me_axZUD-ooXR2NqqNRJQf1T7oSLfZ6nb9sd2jPodVy679Z-7oYHVzz3M4_Y-0iJtnUsJsThs3Fo8esivEYDVqf2x8pm_z_9_gLzRyffw</recordid><startdate>1985</startdate><enddate>1985</enddate><creator>Lewis, Jannet F.</creator><creator>Verani, Mario S.</creator><creator>Poliner, Lawrence R.</creator><creator>Lewis, John M.</creator><creator>Raizner, Albert E.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1985</creationdate><title>Effects of transluminal coronary angioplasty on left ventricular systolic and diastolic function at rest and during exercise</title><author>Lewis, Jannet F. ; Verani, Mario S. ; Poliner, Lawrence R. ; Lewis, John M. ; Raizner, Albert E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-3ce234905d283b9089e30203bf023ff13cde1384198e27d2d2ec0bcd904327f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Angioplasty, Balloon</topic><topic>Biological and medical sciences</topic><topic>Cardiac Output</topic><topic>Cardiology. Vascular system</topic><topic>Coronary Disease - diagnostic imaging</topic><topic>Coronary Disease - physiopathology</topic><topic>Coronary Disease - therapy</topic><topic>Coronary heart disease</topic><topic>Coronary Vessels - diagnostic imaging</topic><topic>Diastole</topic><topic>Exercise Test</topic><topic>Female</topic><topic>Heart</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Radionuclide Imaging</topic><topic>Stroke Volume</topic><topic>Systole</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lewis, Jannet F.</creatorcontrib><creatorcontrib>Verani, Mario S.</creatorcontrib><creatorcontrib>Poliner, Lawrence R.</creatorcontrib><creatorcontrib>Lewis, John M.</creatorcontrib><creatorcontrib>Raizner, Albert E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lewis, Jannet F.</au><au>Verani, Mario S.</au><au>Poliner, Lawrence R.</au><au>Lewis, John M.</au><au>Raizner, Albert E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of transluminal coronary angioplasty on left ventricular systolic and diastolic function at rest and during exercise</atitle><jtitle>The American heart journal</jtitle><addtitle>Am Heart J</addtitle><date>1985</date><risdate>1985</risdate><volume>109</volume><issue>4</issue><spage>792</spage><epage>798</epage><pages>792-798</pages><issn>0002-8703</issn><eissn>1097-6744</eissn><coden>AHJOA2</coden><abstract>The left ventricular global and regional systolic function, ventricular volumes, and peak diastolic filling rate (PDFR) were studied in 30 patients with coronary artery disease, before and 2 to 5 days after transluminal coronary angioplasty (PTCA), utilizing equilibrium radionuclide angiography at rest and during exercise. At rest, the global ejection fraction (EF) was unchanged before (60 ± 9%) and after PTCA (62 ± 10%). During exercise, global EF increased from 59 ± 11% pre PTCA to 67 ± 10 post PTCA (
p < 0.001). Twenty-two patients had abnormal EF response to exercise pre PTCA, versus seven post PTCA (
p < 0.001). Improvements in exercise regional EF paralleled the changes in global EF. End-systolic volume was unchanged at rest but decreased significantly with exercise post PTCA (60 ± 36 ml pre vs 49 ± 32 ml post PTCA,
p < 0.01). At rest, the PDFR was unchanged post PTCA (2.4 ± 0.9 end-diastolic volume (EDV)/sec pre vs 2.5 ± 0.8 EDV/sec post). During exercise, PDFR increased from 2.1 ± 0.7 EDV/sec pre PTCA to 2.5 ± 0.7 EDV/sec post PTCA (
p < 0.02). In conclusion, in patients with coronary artery disease, successful PTCA improves global and regional systolic function during exercise. Diastolic function is improved during exercise, a fact not previously demonstrated.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>3157303</pmid><doi>10.1016/0002-8703(85)90640-4</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Angioplasty, Balloon Biological and medical sciences Cardiac Output Cardiology. Vascular system Coronary Disease - diagnostic imaging Coronary Disease - physiopathology Coronary Disease - therapy Coronary heart disease Coronary Vessels - diagnostic imaging Diastole Exercise Test Female Heart Humans Male Medical sciences Middle Aged Radionuclide Imaging Stroke Volume Systole |
| title | Effects of transluminal coronary angioplasty on left ventricular systolic and diastolic function at rest and during exercise |
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